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TRANSDUCTION: 作品数：235被引量：650H指数：13; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：张罗韩德民卢从明张建华贾文锁更多>>; 相关机构：首都医科大学中国科学院上海生命科学研究院四川大学中国农业大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市科技计划项目更多>>

Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer被引量：3: 《World Journal of Gastroenterology》2016年第31期7046-7057,共12页Chi-Hin Wong You-Jia Li Yang-Chao Chen; Supported by the General Research Fund,Research Grants Council of Hong Kong,No.CUHK462211,No.CUHK462713 and No.14102714;the National Natural Science Foundation of China,No.81101888 and No.8142730; Pancreatic ductal adenocarcinoma(PDAC) is a common pancreatic cancer and the fourth leading cause of cancer death in the United States. Treating this life-threatening disease remains challenging due to the lack of eff...; 关键词：Acinar cells Acinar-to-ductal METAPLASIA Pancreatic DUCTAL ADENOCARCINOMA Signal TRANSDUCTION REPROGRAMMING

Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma被引量：2: 《World Journal of Gastroenterology》2015年第13期3983-3993,共11页Gang Wang Jia-Hui Chen Yong Qiang Dong-Zhi Wang Zhong Chen; AIM: To investigate the role of signal transduction and activation of transcription 4(STAT4) in the development and progression of human hepatocellular carcinoma(HCC).METHODS: Recent genetic investigations have identi...; 关键词：Signal TRANSDUCTION and ACTIVATION of transcriptio

Chemokines,chemokine receptors and the gastrointestinal system被引量：4: 《World Journal of Gastroenterology》2013年第19期2847-2863,共17页Hiroshi Miyazaki Kazuaki Takabe W Andrew Yeudall; The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors,which include epidermal growth factor receptor agonists and members of the transforming growth factor ...; 关键词：CHEMOKINE Receptor Signal TRANSDUCTION Tumor PROGRESSION Targeted THERAPEUTICS DIGESTIVE system Cancer

CABYR RNAi plasmid construction and NF-κB signal transduction pathway被引量：2: 《World Journal of Gastroenterology》2010年第39期4980-4985,共6页Lin-Xiang Shi,Yao-Ming He,Lin Fang,Hong-Bo Meng,Li-Jun Zheng,Department of General Surgery,Shanghai Tenth People’s Hospital,Tongji University,Shanghai 200072,China; Supported by Grants from Natural Science Foundation of China, No.30940034; AIM:To construct the CABYR RNAi plasmid and study its relation with the nuclear factor(NF)-κB signal transduction pathway.METHODS:Human CABYR mRNA sequence was obtained from GenBank.The structure of cDNA sequence for...; 关键词：CABYR PLASMID NUCLEAR factor-κB Signal TRANSDUCTION RNAI Cabyrmid 2

Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo被引量：1: 《World Journal of Gastroenterology》2009年第22期2754-2762,共9页Michael A van Geer Conny T Bakker Naoya Koizumi Hiroyuki Mizuguchi John G Wesseling Ronald PJ Oude Elferink Piter J Bosma; Supported by Maurits en Anna de Kock fund to MA van Geer; AIM:To generate an adenoviral vector specifically targeting the EphA2 receptor(EphA2R) highly expressed on pancreatic cancer cells in vivo.METHODS:YSA,a small peptide ligand that binds the EphA2R with high affinity,wa...; 关键词：Pancreatic cancer ADENOVIRUSES Ephrin A receptor Targeting Genetic transduction

Mechanisms of regulation and function of G-protein-coupled receptor kinases被引量：1: 《World Journal of Gastroenterology》2006年第48期7753-7757,共5页Wen Yang Shi-Hai Xia; Supported by the National Natural Science Foundation of China, No. 30300465; Scientific Research Fund of Medical College of Chinese People’s Armed Police Forces, No. WY2002-19; G-protein-coupled receptor kinases (GRKs) interact with the agonist-activated form of G-protein-coupled receptor (GPCR) to affect receptor phosphorylation and to initiate profound impairment of receptor signaling, or ...; 关键词：G-protein-coupled receptor kinases G-protein-coupled receptor SIGNAL TRANSDUCTION PHOSPHORYLATION

Efficient expression of histidine-tagged large hepatitis delta antigen in baculovirus-transduced baby hamster kidney cells被引量：4: 《World Journal of Gastroenterology》2006年第10期1551-1557,共7页Ying-Wei Chiang Jaw-Chin Wu Kuei-Chun Wang Chia-Wei Lai Yao-Chi Chung Yu-Chen Hu; Supported by National Health Research Institutes (NHRI-EX94-9412EI); VTY Joint Research Program, Tsou's Foundation (VGHUST94-P6-32); AIM： To study the baculovirus/mammalian cell system for efficient expression of functional large hepatitis delta antigen （L-HDAg）. METHODS： A recombinant baculovirus expressing histidine-tagged L-HDAg （L-HDAgH） ...; 关键词：BACULOVIRUS Hepatitis delta virus L-HDAg Mammalian cell Protein expression TRANSDUCTION

TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway被引量：22: 《World Journal of Gastroenterology》2005年第2期221-227,共7页MeiShi XiaZhang PingWang Hong-WeiZhang Bai-HeZhang Meng-ChaoWu; AIM: To investigate the role of TIP30 in apoptotic signal pathway in hepatoblastoma cells and to provide a basis for TIP30 as a gene therapy candidate in the regression of hepatoblastoma cells. METHODS: Apoptosis of h...; 关键词：HEPATOBLASTOMA TIP30 APOPTOSIS Signa transduction

Inhibitory effect of endostatin expressed by human liver carcinoma SMMC7721 on endothelial cell proliferation in vitro被引量：11: 《World Journal of Gastroenterology》2002年第2期253-257,共5页Xuan Wang Fu-Kun Liu Xi Li Jai-Sou Li,Research Institute of General Surgery,Clinical School of Medicine,Nanjing University,Nanjing 210002,Jiangsu Province,China Gen-Xin Xu,Department of Molecular Biology,Nanjing Military Medical School,Nanjing 210002,Jiangsu Province,China; AIM: To construct a stable transfectant of human liver carcinoma cell line SMMC7721 that could secret human endostatin and to explore the effect of human endostatin expressed by the transfectant on endothelial cell pr...; 关键词：Animals Antineoplastic Agents CARCINOMA Cell Line Collagen ENDOSTATINS Endothelium Vascular Humans Liver Neoplasms Peptide Fragments Rats Recombinant Fusion Proteins Transduction Genetic Tumor Cells Cultured

Effect of vitamin E succinate on expression of TGF-β_1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells被引量：17: 《World Journal of Gastroenterology》2001年第1期83-87,共5页Kun Wu Bai He Liu Dan Yang Zhao Yan Zhao Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, Heilongjiang Province, China; Project supported by National Natural Science Foundation of China, No. 39870662; INTRODUCTIONVitamin E succinate (RRR-α-Tocopheryl Succinate,VES), a derivative of natural vitamin E, is acompound esterified by succinic acid and 6-hydroxyl-α-tocopheryl.; 关键词：stomach neoplasms apoptosis signal TRANSDUCTION VITAMIN E enzyme-linked IMMUNOSORBENT assay blotting western FLOWCYTOMETRY

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