funding from the Medical Research Council (MR/S006990/1, MR/Y010949/1);the Rosetrees Trust (M806);the UCL Neurogenetic Therapies Programme funded by The Sigrid Rausing Trust and the UCL Therapeutic Acceleration Support scheme supported by funding from MRC IAA 2021 UCL MR/X502984/1 (to JNS)。
Charcot-Marie-Tooth disease(CMT) is a heterogeneous group of inherited peripheral neuro pathies;it is characterized by muscle weakness and wasting,as well as sensory dysfunction,that typically begins during adolescenc...
Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is acco...
Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postu...
The Editors of Neural Regeneration Research have retracted the publication entitled“Emerging concepts underlying selective neuromuscular dysfunction in infantile-onset spinal muscular atrophy”(Gollapalli et al.,2021...
This work was supported by the Defense Threat Reduction Agency-Joint Science&Technology Office for Chemical&Biological Defense(No.11816372);the Nehemia Rubin Excellence in Biomedical Research-The TELEM Program supported by the Aaron Gutwirth Fund and by Ministry of Science and Technology(No.3-13576).
Our ageing population is bearing an increasing burden on society with an unprecedented rise in brain disease,especially neurodegeneration.Treatment for neurodegeneration is practically nonexistent,one major reason bei...
Although the transcriptional alterations inside the facial nucleus after facial nerve injury have been well studied,the gene expression changes in the facial nerve trunk after injury are still unknown.In this study,we...
Stroke is the second leading cause of death worldwide with about 50% of survivors being chronically disabled(Donkor,2018).The behavioral improvement seen in stroke patients in the first weeks after a stroke is contrib...
This work was supported by the National Natural Science Foundation of China,Nos.81072947,81473470,81774423,the Natural Science Foundation of Guangdong Province of China,No.2014A030311033(all to FT).
The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair.After cerebral ischemia/reperfusion,microglia are activated,and a large number of circulating infla...
Motor neurons are highly polarized cells,with long axons that extend to more than 1 m in the adult human.The axons further arborize into a specialized synaptic compartment,the motor unit,containing up to 2000 neuromus...
supported by the National Natural Science Foundation of China,No.81173355
Simple regulation of c-Jun N-terminal kinase(JNK) or p38 mitogen-activated protein kinase(MAPK) pathways is not enough to trigger cell apoptosis.However,activation of the stress activated pathway(JNK/p38 MAPK) t...