supported by the National Natural Science Foundation of China,Nos.82274313(to YD),82204746(to ML),82003982(to TL).
It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing a...
Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes mellitus.Diabetic corneal neuropathy refers to the progressive damage of corneal nerves.Diabetic retin...
supported by grants from NIH(RF1AG072491 and R01AI132695)to RM.
Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)patients.Moreover,Aβdeposits have been identified in peripheral tissues.However,the relevance of peri...
supported by the National Natural Science Foundation of China,No.82071442 (to LS);a grant from the Jilin Provincial Department of Finance,No.JLSWSRCZX2021-004 (to LS)。
Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative st...
supported by the National Institute on Aging of NIH(No.RF1AG072510 to HW);the National Institute of General Medical Sciences(NINGM)of NIH(No.P20GM103443 to HW via Dr.Victor Huber);the National Science Foundation(NSF)(No.DGE-1633213 to CCH via Dr.Brian Burrell);the NIH/NIGMS(No.T32GM-136503 to CCH via Dr.Brian Burrell)。
Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming years.While thera...
Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid metabolism.As neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly m...
By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intra cellular calcium fluxes.Mortalin is a chaperone protein that pla...
Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes,the mitochondria are required for multiple pivotal processes that include the production of biological energy,the biosynth...
Trace amines and their biochemistry: Trace amines represent endogenous monoamines present in very low concentration(usually nM) in the brain in comparison to classical monoamine neurotransmitters.These trace amines ca...