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Extracellular ATP-activated hybridization chain reaction for accurate and sensitive detection of cancer cells: 《Chinese Chemical Letters》2023年第12期495-498,共4页Lie Li Suping Li Jie Wang Xiaohong Wen Mei Yang Haiyan Chen Qiuping Guo Kemin Wang; supported by the Natural Science Foundation of China(Nos.21877030,21735002 and 21778016).; Accurate and sensitive detection of caner cells is of significant importance for early diagnosis and treat-ment of cancer.Here,we developed an extracellular ATP-dctivated hybridization chain reaction(HCR)amplification...; 关键词：Cancer cells ATP APTAMER Hybridization chain reaction Fluorescence

Multicellular tumor spheroids bridge the gap between two-dimensional cancer cells and solid tumors: The role of lipid metabolism and distribution被引量：1: 《Chinese Chemical Letters》2023年第2期259-262,共4页Peisi Xie Jinghui Zhang Pengfei Wu Yongjiang Wu Yanjun Hong Jianing Wang Zongwei Cai; supported by National Natural Science Foundation of China (Nos. 22036001, 22106130 and 91843301);Research Grant Council (Nos. 463612 and 14104314) of Hong Kong。; Previous studies demonstrated that three-dimensional(3D) multicellular tumor spheroids(MCTS) could more closely mimic solid tumors than two-dimensional(2D) cancer cells in terms of the spatial structure, extracellular...; 关键词：Lipid metabolism Lipid distribution Two-dimensional cells Three-dimensional cell spheroids Solid tumors

Dual microenvironmental parameter-responsive lysosome-targeting carbon dots for the high contrast discrimination of a broad spectrum of cancer cells: 《Chinese Chemical Letters》2022年第12期5051-5055,共5页Yue Xiao Xiaohui Yin Pengjuan Sun Yuanqiang Sun Lingbo Qu Zhaohui Li; supported by the National Natural Science Foundation of China(Nos.21974125,21708035);Program for Innovative Research Team(in Science and Technology)in University of Henan Province(No.22TRTSTHN002);the 111 Project of Henan Province(No.CXJD2021001);National 111 Project(No.D20003).; The development of new carbon dots(CDs)for fluorescence-based cancer diagnosis has recently attracted extensive attention.Diagnosis methods based on ligand-receptor fluorescence suffer from the heterogeneity of recept...; 关键词：Carbon dots Multiple microenvironmental parameters Lysosome-targeting High contrast imaging Cancer diagnosis

Boronic acid-containing carbon dots array for sensitive identification of glycoproteins and cancer cells: 《Chinese Chemical Letters》2021年第10期3043-3047,共5页Shuai Chen Xuewei Zhang Yongliang Yu Jianhua Wang; financially supported by the National Natural Science Foundation of China(Nos.21922402,21874017 and21727811);Liaoning Provincial Program for Promoting Talents(Nos.XLYC1807005 and XLYC1802016);the Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University,Ministry of Education,China,111 Project,No.B16009)。; Discrimination of glycoproteins and cell types is a significant but difficult issue.Herein,we presented a novel fluorescence sensor array for the detection and identification of glycoproteins and cancer cells based on...; 关键词：Sensor array Boronic acid Carbon dots Glycoproteins and cells Aggregation-enhanced emission

A GSH-responsive PET-based fluorescent probe for cancer cells imaging被引量：3: 《Chinese Chemical Letters》2021年第4期1541-1544,共4页Xue Li Huaying Wang Youhui Zhang Qianyong Cao Yong Chen; supported by the National Nature Science Foundation of China(Nos.21762028 and 21462027);the Nature Science Foundation of Jiangxi Province of China(No.20172BCB22007),which are greatly acknowledged by the authors。; An efficient PET-based probe,in which the ferrocene quencher and the naphthalimide fluorophore are linked by a disulfide bond,has been developed.This probe can be activated by GSH with fluorescence a turn-on response ...; 关键词：GSH sensing Photoinduced electron transfer Fluorescent sensor Cancer cells imaging

NIR-triggered drug delivery system based on phospholipid coated ordered mesoporous carbon for synergistic chemo-photothermal therapy of cancer cells被引量：3: 《Chinese Chemical Letters》2020年第12期3158-3162,共5页Anman Zhang Luo Hai Tianzheng Wang Hong Cheng Man Li Xiaoxiao He Kemin Wang; the National Natural Science Foundation of China(Nos.21735002,21521063,21675046,21874035,21806186 and 21775036);the Natural Science Foundation of Hunan Province,China(No.2018JJ2033);the Key Point Research and Invention Program of Hunan Province,China(No.2017DK2011)。; Chemo-photothermal treatment is one of the most efficient strategies for cancer therapy.However,traditional drug carriers without near-infrared absorption capacity need to be loaded with materials behaving phototherma...; 关键词：Ordered mesoporous carbon Polyethylene glycol linked liposomes Stimuli-responsive drug delivery system NIR-triggered drug delivery Chemo-photothermal therapy

Extracellular vesicles based electrochemical biosensors for detection of cancer cells:A review被引量：1: 《Chinese Chemical Letters》2020年第7期1737-1745,共9页Hui Xie Kaili Di Rongrong Huang Adeel Khan Yanyan Xia Hongpan Xu Chang Liu Tingting Tan Xinyu Tian Han Shen Nongyue He Zhiyang Li; the National Natural Science Foundation of China(Nos.61971216 and 61527806);National Key Research and Development Program of China(No.2017YFA0205301);the Jiangsu Province Medical Talent(No.ZDRCA2016065);the Key Research and Development Project of Jiangsu Province(No.BE2019603);the Health Care for Cadres Research Fund ofjiangsu Province(No.BJ16003);High-level Health Talent Project of Jiangsu Province(No.LGY2019001)。; Extracellular vesicles(EVs)derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis,and are stable and abundant.Electrochemical methods for the detection of EVs are prefe rred ...; 关键词：Cancerous Extracellular vesicles ELECTROCHEMICAL Biosensors DETECTION

Transformable peptide nanoparticles inhibit the migration of N-cadherin overexpressed cancer cells被引量：1: 《Chinese Chemical Letters》2020年第7期1787-1791,共5页Jiaqi Fan Yu Fan Zijin Wei Yijing Li Xiangdan Li Lei Wang Hao Wang; the National Natural Science Foundation of China(Nos.51890891,51725302,21807020,51573031 and 51573032);National Key R&D Program of China(No.2018YFE0205400);Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.11621505);CAS Interdisciplinary Innovation Team。; About 90%cancer-related mortality results from the cancer metastasis,which generally undergoes after epithelial-mesenchymal transition(EMT)process.N-Cadherin,overexpressed on cancer cell surface during EMT,can enhance...; 关键词：SELF-ASSEMBLY PEPTIDE N-CADHERIN Cancer Ligand-receptor interaction

Cholesterol as a functional metabolite cooperates with metadherin in cancer cells: 《Chinese Chemical Letters》2020年第7期1831-1834,共4页Wen Wang Xiaolong Liu Huan Chen Ting Ling Tian Xia Xiumei Liu Jing Liu Wuxiyar Otkur Xianzhe Shi Huan Qi Di Chen Hai-Long Piao; the National Natural Science Foundation of China(Nos.81672440,21575142);Innovation Program of Science and Research from the DICP,CAS(No.DICP ZZBS201803)。; Protein-metabolite interactions(PMIs)play important roles in various biological processes,especially in disease progression.However,due to the complexity of living cells,it is very difficult to identify specific PMIs....; 关键词：Metabolite-protein interaction CHOLESTEROL Metadherin Mass spectrometry

A photosensitizer-loaded zinc oxide-polydopamine core-shell nanotherapeutic agent for photodynamic and photothermal synergistic therapy of cancer cells被引量：3: 《Chinese Chemical Letters》2020年第1期189-192,共4页Ri Wu Huizhen Wang Luo Hai Tianzheng Wang Min Hou Dinggeng He Xiaoxiao He Kemin Wang; supported in part by the Key Project of Natural Science Foundation of China (Nos.21775036,21675046,21735002, 21521063 and 21874035);the Key Point Research and Invention Program of Hunan Province (No.2017DK2011);the Research Foundation of Education Bureau of Hunan Province (No.18B027);the Hunan Provincial Natural Science Foundation (No.2018JJ2033); In clinical cancer research,it is quite promising to develop multimodal synergistic therapeutic strategies.Photodynamic and photothermal synergistic therapy is a very desirable multimodal therapy strategy.Herein,we re...; 关键词：Ce6 POLYDOPAMINE Photodynamic therapy Photothermal therapy

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