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Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken: 《Journal of Animal Science and Biotechnology》2025年第2期551-564,共14页Jingwei Yuan Yuanmei Wang Yanyan Sun Yunlei Li Aixin Ni Qin Li Hanhan Yang Xinying Xu Yunhe Zong Hui Ma Jilan Chen; supported by the grants from National Natural Science Foundation of China(32302724 to Jingwei Yuan);the China Agriculture Research System of MOF and MARA(CARS-40 to Yanyan Sun);the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences(ASTIP-IAS16 to Jilan Chen)。; Background Crossbreeding is widely promoted as an efficient strategy to improve the productivity in agriculture.The molecular mechanism underlying heterosis for egg production is always intriguing in chicken.The trans...; 关键词：Cell cycle CHICKEN DOMINANCE Egg production heterosis Ovary transcriptome WGCNA

IFNα2b/5-FU inhibits proliferation and cell cycle of squamous carcinoma cell line Cal27: 《International Journal of Ophthalmology(English edition)》2025年第4期565-574,共10页Zong-Bo Wu Gong-Yue Wang Bei Wang Xi Peng Jia-Song Wang Ming-Chang Zhang Wen Geng Hua-Tao Xie; All data and materials are available in the article upon reasonable request to the corresponding author.Foundations:Supported by the National Natural Science Foundation of China(No.82070934;No.82171025).; AIM:To investigate the pathological features of ocular surface squamous neoplasia(OSSN)and evaluate the synergistic therapeutic effects of interferon-α2b(IFNα2b)and 5-fluorouracil(5-FU)on cellular proliferation,migr...; 关键词：ocular surface squamous neoplasia squamous carcinoma cells interferon-α2b 5-FLUOROURACIL combination index

The Pathophysiologic Role of Oxidative Stress in Mitotic Cell Division: 《BIOCELL》2025年第3期419-435,共17页Nathan Isaac Dibal Martha Orendu Oche Attah; Oxidative stress is characterized by elevated intracellular reactive oxygen species(ROS)levels.At physiological levels,ROS work as signaling molecules,helping cells go through the cell cycle normally and keeping their...; 关键词：Cell cycle MITOSIS oxidative stress ROS

Epibrassinolide Induces Apoptosis and Inhibits the Migration of Gastric Cancer AGS Cells by Regulating Reactive Oxygen Species-Mediated Signaling Pathways: 《BIOCELL》2025年第3期465-482,共18页Chang Wang Zhi Zhang Wei Sun Quan Quan Wenshuang Hou Chenghao Jin; supported by the Heilongjiang Province Key Research and Development Plan Guidance Project[Grant No.GZ20220039];the Central Government Supports the Local College Reform and Development Fund Talent Training Project[Grant No.2020GSP16].; Objectives:Epibrassinolide(EBR)is a steroid hormone with anti-tumor properties.Nevertheless,its potential to inhibit gastric cancer(GC)cells remains unknown.The aim of this research was to examine the effects of EBR o...; 关键词：EPIBRASSINOLIDE gastric cancer cell apoptosis cell cycle cell migration

Recent advances in regulating the cell cycle through inhibiting CDKs for cancer treatment: 《Chinese Journal of Natural Medicines》2025年第3期286-298,共13页Weijiao Chen Xujie Zhuang Yuanyuan Chen Huanaoyu Yang Linhu Shen Sikai Feng Wenjian Min Kai Yuan Peng Yang; supported by the National Key R&D Program of China(No.2023YFC2706303);the National Natural Science Foundation of China(Nos.82373738 and 82304293);Natural Science Foundation of Jiangsu Province(Nos.SBK2024090146 and BK20221040).; The inhibition of cyclin-dependent kinases(CDKs)is considered a promising strategy for cancer treatment due to their role in cell cycle regulation.However,CDK inhibitors with no selectivity among CDK families have not...; 关键词：Cell cycle Cyclin-dependent kinase(CDK) CDK inhibitor RESISTANCE

MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway: 《Genes & Diseases》2025年第1期341-354,共14页Zhenmin Liu Xingguo Luo Zhicheng Zhang Qiang Zhang Chong Wang Hongsong Chen Chunlan Long Xing Liu Guanghui Wei; financed by the National Natural Science Foundation of China(No.81970571);the Natural Science Foundation of Chongqing Municipality,China(No.CSTB2022NSCQ-MSX1001);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0109).; MAFB is essential for regulating male-type urethral differentiation,and especially,its variation can contribute to hypospadias in mice.However,the potential mechanism is still unclear.Here we observed that the basic l...; 关键词：APOPTOSIS CEBPA Cell cycle MAFB UROTHELIUM Wnt/β-catenin signaling pathway

The Role of GSPT2 in Tumor Cell Cycle Regulation: Mechanisms and Clinical Significance: 《Journal of Cancer Therapy》2025年第1期18-27,共10页Yu Cai Yumei Wu; GSPT2 (G1 to S phase transition protein 2) has emerged as a critical regulator of the cell cycle and has garnered increased attention for its role in tumor biology in recent years. This review explores the multifacete...; 关键词：GSPT2 TUMOR BIOMARKER Cell Cycle SIGNALING

CD4 T cell contact drives macrophage cell cycle G0-G1 transition: 《Signal Transduction and Targeted Therapy》2025年第1期21-23,共3页Petra Mlcochova Na Zhao Omar Shabana Roman Fischer Ravindra K.Gupta; supported by the NIHR Cambridge Biomedical Research Centre(NIHR203312).; Dear Editor Macrophages are cells implicated in a diverse array of functions such as defence against pathogens,tissue repair/homoeostasis,and anti-cancer activity.1,2 Macrophages are also targets of virus infection,an...; 关键词：STASIS MACROPHAGE infection

Targeting cell cycle regulators:A new paradigm in cancer therapeutics: 《BIOCELL》2024年第12期1639-1666,共28页GARIMA SINGH SONIKA KUMARI SHARMA NEELU MISHRA AASTHA SONI MANSHI KUMARI SAMARENDRA KUMAR SINGH; Dysregulation of the cell cycle is a molecular hallmark of cancer,which leads to uncontrolled proliferation and self-renewal of neoplastic cells.To maintain this phenotype,cells acquire multiple molecular alterations ...; 关键词：CYCLINS Cyclin-dependent kinases TAXANES Cell cycle inhibitors Targeted therapy

Surreal Numbers, Dyadic Rational Numbers and Cell Proliferation: 《Journal of Applied Mathematics and Physics》2024年第12期4170-4182,共13页Verónica Judith Picos-Cárdenas Juan Pablo Meza-Espinoza Nayeli Nieto-Marín Liliana Itzel Patrón-Baro Juan Antonio Nieto; The growth of multicellular organisms is directly related to cell proliferation through the cell cycle, in which a single cell grows and divides to produce two daughter cells. This process leads to an exponential incr...; 关键词：Surreal Numbers Dyadic Rational Cell Cycle Cell Proliferation

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