This work was supported by the National Basic Research Program(973 Program;2015CB96A902);the National Natural Science Foundation of China(H81170466 and H81370597);and the CAMS Initiatives for Innovative Medicine(2016-I2M-1-018)awarded to F.M.;the CAMS Initiatives for Innovative Medicine(2017-12M-2005);the Union Youth Fund of Chinese Academy of Medical Sciences(81572089)to G.B.;and the National Nature Science Foundation of China Youth Fund(81700107)to B.M.
Mast cells (MCs) play a pivotal role in the hypersensitivity reaction by regulating the innate and adaptive immune responses. Humans have two types of MCs. The first type, termed MCTC, is found in the skin and other c...
Supported by Science and Technology Project of Liaoning Province;No.2013225303;Science and Technology Project of Shenyang City;No.F13-316-1-40
AIM: To investigate the effect of chymase inhibitor TY-51469 in the therapy of inflammatory bowel disease and the underlying mechanism. METHODS: Seventy-five healthy Sprague-Dawley rats were randomly assigned to one o...
Supported by Comisión Nacional de Investigación Científicay Tecnológica(CONICYT,Chile)grants FONDECYT 1121060(to JEJ and MPO),FONDEF D11I1122(to MPO and JEJ)and FONDAP 15130011(to MPO)
Asymptomatic organ damage due to progressive kidney damage, cardiac hypertrophy and remodeling put hypertensive patients at high risk for developing heart and renal failure, myocardial infarction and stroke. Current a...
AIM: To evaluate the role of chymase in blood pressure regulation and its actions on tissue renin-angiotensin system.METHODS: A two-kidney, one-clip(2K1C) hypertension model was developed in Syrian hamsters, which hav...
Project supported by the National Natural Science Foundation of China (No. 30670867) to Mei-xiang XIANG;the Major Program of Science and Technology Department of Zhejiang Province,China(No. 2007C13058) to Mei-xiang XIANG
Objective:The gene for mast cell chymase (CMA1) is an ideal candidate for investigating the genetic predisposition to coronary heart disease (CHD),as activated mast cells have been found to be present in a greater pro...