DISEASES

作品数：2127被引量：7898H指数：32
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  • 期刊=Signal Transduction and Targeted Therapyx
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Nucleic acid drugs:recent progress and future perspectives
《Signal Transduction and Targeted Therapy》2024年第12期5610-5640,共31页Xiaoyi Sun Sarra Setrerrahmane Chencheng Li Jialiang Hu Hanmei Xu 
supported by the National Natural Science Foundation of China(82373039);the University-Industry Collaboration Program(New Drug Targets and New Molecule Discovery and Technology 8210040001,2020-019)。
High efficacy,selectivity and cellular targeting of therapeutic agents has been an active area of investigation for decades.Currently,most clinically approved therapeutics are small molecules or protein/antibody biolo...
关键词：DRUGS DISEASES typically 
Iron homeostasis and ferroptosis in human diseases:mechanisms and therapeutic prospects被引量：1
《Signal Transduction and Targeted Therapy》2024年第11期5015-5078,共64页Qin Ru Yusheng Li Lin Chen Yuxiang Wu Junxia Min Fudi Wang 
supported in part by the National Natural Science Foundation of China(31970689 to J.M.,32330047 and 31930057 to F.W.,82071970 to Y.W.and 82072506 to Y.L.);the Science Fund for Distinguished Young Scholars of Hubei Province(2023AFA109 to Y.W.);Hubei Provincial Natural Science Foundation of China(2024AFB971 to Q.R.).
Iron,an essential mineral in the body,is involved in numerous physiological processes,making the maintenance of iron homeostasis crucial for overall health.Both iron overload and deficiency can cause various disorders...
关键词：DISEASES HOMEOSTASIS THERAPEUTIC 
Miniproteins may have a big impact:new therapeutics for autoimmune diseases and beyond
《Signal Transduction and Targeted Therapy》2024年第11期4785-4787,共3页Nariaki Asada Christian F.Krebs Ulf Panzer 
supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to U.P.(SFB 1192 A1 and C3);C.F.K.(SFB 1192 A5 and C3,KR 3483/3-1).
In a landmark study recently published in Cell,Berger et al.demonstrated that computationally designed miniproteins could serve as novel,orally available treatment strategies by specifically targeting cytokine signali...
关键词：AUTOIMMUNE DISEASES 
Metabolic regulation of the immune system in health and diseases:mechanisms and interventions
《Signal Transduction and Targeted Therapy》2024年第11期4904-4934,共31页Tengyue Hu Chang-Hai Liu Min Lei Qingmin Zeng Li Li Hong Tang Nannan Zhang 
supported by the National Natural Science Foundation(81970738);the Natural science foundation project of Sichuan(2024NSFSC0599);the Key Research and Development Program of Chengdu(2023-YF09-00052-SN);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD23030);the National Key Research and Development Program of China(No.2022YFC2304800).
Metabolism,including glycolysis,oxidative phosphorylation,fatty acid oxidation,and other metabolic pathways,impacts the phenotypes and functions of immune cells.The metabolic regulation of the immune system is importa...
关键词：METABOLISM DISEASES summarized 
The multiple roles of interferon regulatory factor family in health and disease
《Signal Transduction and Targeted Therapy》2024年第11期4935-4982,共48页Lian Wang Yanghui Zhu Nan Zhang Yali Xian Yu Tang Jing Ye Fekrazad Reza Gu He Xiang Wen Xian Jiang 
supported by the Fundamental Research Funds for the National Natural Science Foundation of China(Nos.82103757,82273559,82104373 and 82304063);Sichuan Natural Science Foundation Project(2023NSFSC1554 and 24NSFSC5087).
Interferon Regulatory Factors(IRFs),a family of transcription factors,profoundly influence the immune system,impacting both physiological and pathological processes.This review explores the diverse functions of nine m...
关键词：DISEASES PRECISE PHYSIOLOGICAL 
Allogeneic CAR T cells for autoimmune diseases:a glimpse into the future
《Signal Transduction and Targeted Therapy》2024年第11期4758-4759,共2页Dimitrios Mougiakakos 
supported by the Deutsche Forschungsgemeinschaft(DFG,project nr.536993790);the European Regional Development Fund(project ZELL-THEMA).
In a recent study published in Cell,Wang X et al.1 reported the first use of allogeneic anti-CD19 CAR T cells in patients with therapyresistant autoimmune diseases,demonstrating their effectiveness in reducing disease...
关键词：AUTOIMMUNE DISEASES 
Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases被引量：1
《Signal Transduction and Targeted Therapy》2024年第10期4341-4378,共38页Weiyi Yao Xinting Hu Xin Wang 
National Natural Science Foundation(No.82270200,No.82070203 and No.81770210);Taishan Scholars Program of Shandong Province;Shandong Provincial Engineering Research Center of Lymphoma;Key Research and Development Program of Shandong Province(No.2018CXGC1213);Academic Promotion Programme of Shandong First Medical University(No.2019QL018);Translational Research Grant of NCRCH(No.2021WWB02,No.2020ZKMB01).
Histone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases an...
关键词：DISEASES METABOLISM EPIGENETIC 
Sex difference in human diseases:mechanistic insights and clinical implications被引量：1
《Signal Transduction and Targeted Therapy》2024年第10期4213-4245,共33页Yuncong Shi Jianshuai Ma Sijin Li Chao Liu Yuning Liu Jie Chen Ningning Liu Shiming Liu Hui Huang 
National Key Research and Development Program(2020YFC2004405);National Natural Science Foundation of China(82330021,82061160372,82270771);Central Military Commission Key Project of Basic Research for Application(BWJ21J003);Regional Joint Funding Key Project of Guangdong Basic Research and Basic Research for Application(2021B1515120083);Shenzhen Science and Technology Program(KCXFZ20211020163801002,ZDSYS20220606100801004,SGDX20230116092459009);Shenzhen Medical Research Fund(B2302020);Shenzhen Key Medical Discipline Construction Fund(SZXK002);Futian District Public Health Scientific Research Project of Shenzhen(FTWS2022001);Chinese Association of Integrative Medicine-Shanghai Hutchison Pharmaceuticals Fund(HMPE202202);China Heart House-Chinese Cardiovascular Association HX fund(2022-CCA-HX-090)to Hui Huang;National Natural Science Foundation of China(82073408)to JC.
Sex characteristics exhibit significant disparities in various human diseases,including prevalent cardiovascular diseases,cancers,metabolic disorders,autoimmune diseases,and neurodegenerative diseases.Risk profiles an...
关键词：DISEASES CLINICAL thereby 
Tertiary lymphoid structures in diseases:immune mechanisms and therapeutic advances
《Signal Transduction and Targeted Therapy》2024年第9期3942-3984,共43页Lianyu Zhao Song Jin Shengyao Wang Zhe Zhang Xuan Wang Zhanwei Chen Xiaohui Wang Shengyun Huang Dongsheng Zhang Haiwei Wu 
supported by Natural Science Foundation of Shandong Province,China(Grant no.ZR2021MH353);Health Science and Technology Team Building Project of Shandong Province.
Tertiary lymphoid structures(TLSs)are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions.Similar to secondary lymphoid organs(SLOs),the formation of TLSs relies on the inte...
关键词：LYMPHOID THERAPEUTIC DISEASES 
Macrophages in cardiovascular diseases:molecular mechanisms and therapeutic targets被引量：7
《Signal Transduction and Targeted Therapy》2024年第6期2598-2641,共44页Runkai Chen Hongrui Zhang Botao Tang Yukun Luo Yufei Yang Xin Zhong Sifei Chen Xinjie Xu Shengkang Huang Canzhao Liu 
supported by grants from the National Students’Platform for Innovation and Entrepreneurship Training Program of China(No.202212121004 and No.202212121023);the Guangdong Students’Platform for Innovation and Entrepreneurship Training Program(No.S202212121074);supported by the National Natural Science Foundation of China(82170231,82370410);Guangdong Basic and Applied Basic Research Foundation(2023B1515020103).
The immune response holds a pivotal role in cardiovascular disease development.As multifunctional cells of the innate immune system,macrophages play an essential role in initial inflammatory response that occurs follo...
关键词：DISEASES CARDIOVASCULAR THERAPEUTIC 
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