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DNA_DAMAGE: 作品数：397被引量：1149H指数：14; 导出分析报告; 相关作者：黄百渠张瑜刘松陆军孙晋渊更多>>; 相关机构：东北师范大学首都师范大学上海交通大学医学院附属新华医院浙江林学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金中国博士后科学基金更多>>

Development of mouse preimplantation embryos in space被引量：13: 《National Science Review》2020年第9期1437-1446,共10页Xiaohua Lei Yujing Cao Baohua Ma Yunfang Zhang Lina Ning Jingjing Qian Liwen Zhang Yongcun Qu Tao Zhang Dehong Li Qi Chen Junchao Shi Xudong Zhang Chiyuan Ma Ying Zhang Enkui Duan; This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA04020202-20 to E-K.D.);the Ministry of Science and Technology of China(2018YFC1004500 to Y.Z.);the National Natural Science Foundation of China(U 1738103 to E-K.D.,31600683 to X-H.L.and 31671201 to Y.Z.);the Strategically Guiding Scientific Special Project from the Chinese Academy of Sciences(XDA15014000 to X-H.L.);the National Key Research and Development Program of China(2017YFC1001401 and 81490742 to E-K.D.).; The development o f life beyond planet Earth is a long-standing quest of the human race,but whether normal mammalian embryonic development can occur in space is still unclear.Here,we show unequivocally that preimplant...; 关键词：SPACE-FLIGHT RADIATION MICROGRAVITY preimplantation development DNA damage DNA methylation

Non-equilibrium and stochasticity influence the activation process of the yeast DNA damage pathway: 《Science China(Physics,Mechanics & Astronomy)》2018年第2期76-79,共4页ChenZi Jin XiaoDong Yan FangTing Li; supported by the National Natural Science Foundation of China(Grant Nos.11174011,and 91130005);the National Key Basic Research Project of China(Grant No.2015CB910300); Living cells are open systems that exist far away from a state of thermodynamical equilibrium. They utilize the high-grade chemical energy provided by food to produce ATP and re- lease ADP and Pi together with heat di...; 关键词：NON-EQUILIBRIUM stochasticity influence DNA damage pathway

Hoechst-naphthalimide dyad with dual emissions as specific and ratiometric sensor for nucleus DNA damage: 《Chinese Chemical Letters》2017年第10期2019-2022,共4页Fu Yang Chao Wang Lu Wang Zhi-Wei Ye Xin-Bo Song Yi Xiao; supported by the National Natural Science Foundation of China (Nos. 21376038, 21421005 and 21576040);National Basic Research Program of China (No. 2013CB733702); A ratiometric fluorescent sensor（Hoe-NI） was developed by connecting a nucleus targeted Hoechst unit to a naphthalimide dye via ＂click chemistry＂. The sensor achieves high specific nucleus labeling with wash-free ...; 关键词：DNA damage Ratiometric sensor Fluorescenct imaging Nucleus labeling NAPHTHALIMIDE

Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage被引量：3: 《Acta Biochimica et Biophysica Sinica》2016年第7期603-616,共14页Yongcan Chen Wei-Guo Zhu; This work was supported by the grants from the National Basic Research Program of China （Nos. 2011CB910100, 2011CB504200, and 2013CB911000）, the National Natural Science Foundation of China （Nos. 81222028, 81321003, 81472581, 81530074, 31570812, and 91319302）, and the Ministry of Science and Technology of China （No. B70001）.; DNA damage response （DDR） signaling network is initiated to protect cells from various exogenous and endogenous damage resources. Timely and accurate regulation of DDR proteins is required for distinct DNA damage re...; 关键词：DNA damage response lysine methylation histone methylation

Effects of DNA damage on oocyte meiotic maturation and early embryonic development: 《Frontiers of Agricultural Science and Engineering》2014年第3期185-190,共6页Shen YIN Junyu MA Wei SHEN; This study was supported by the National Natural Science Foundation of China(31171376 and 31401276);National Basic Research Program of China(2012CB944401).; DNA damage is one of the most common threats to meiotic cells.It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo.Here,we reviewed exogenous factors which could induce...; 关键词：DNA damage double-strand breaks(DSBs) OOCYTE EMBRYO

Damage mechanism of hydroxyl radicals toward adenine–thymine base pair: 《Chinese Physics B》2014年第2期431-436,共6页谈荣日王东琪张丰收; Project supported by the National Natural Science Foundation of China (Grant Nos.11025524 and 11161130520);the National Basic Research Program of China (Grant No.2010CB832903);the Natural Science Foundation of Guizhou Province of China (Grant No.J20122141);the Fund in the framework of a Frontier of Novelty Program of the Chinese Academy of Sciences for one of the authors (Wang Dong-Qi) (Grant No.Y1515540U1);the Research Fund for the Doctoral Program of Jiangxi Science and Technology Normal University (Grant No.3000990110); The adenine-thymine base pair was studied in the presence of hydroxyl radicals in order to probe the hydrogen bond effect. The results show that the hydrogen bonds have little effect on the hydroxylation and dehydroge...; 关键词：DNA damage hydrogen bond effect HYDROXYLATION DEHYDROGENATION

Induced Pluripotent Stem Cells Are Sensitive to DNA Damage被引量：2: 《Genomics, Proteomics & Bioinformatics》2013年第5期320-326,共7页Minjie Zhang Caiyun Yang Huixian Liu Yingli Sun; supported by Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA01040405);National Natural Science Foundation of China(Grant No.91029024);National Basic Research Program of China(973 Program;Grant No.2013CB911001); Induced pluripotent stem cells （iPSCs） resemble embryonic stem cells （ESCs） in morphol- ogy, gene expression and in vitro differentiation, raising new hope for personalized clinical therapy. While many efforts hav...; 关键词：IPSCS MEF cells Γ-H2AX DNA damage Whole-genome sequencing

Mechanical force-induced DNA damage during AFM single-molecule manipulation: 《Nuclear Science and Techniques》2013年第3期66-71,共6页ZHANG Chen DUAN Na DAI Bin ZHANG Yi ZHANG Donghua HU Jun; Supported by National Basic Research Program of China(973 Program Nos.2007CB936000 and 2012CB932600);National Natural Science Foundation of China(No.21073222);Chinese Academy of Sciences(No.KJCX2-EW-N03); Many environmental factors can cause DNA damage, such as radiation, heat, oxygen free radical, etc., which can induce mutation during DNA replication. Meanwhile, DNA molecules are subjected to various mechanical force...; 关键词：原子力显微镜 DNA损伤单分子操纵机械力诱导 DNA突变 DNA复制聚合酶链反应

An E. coli SOS-EGFP biosensor for fast and sensitive detection of DNA damaging agents被引量：2: 《Journal of Environmental Sciences》2012年第3期541-549,共9页Zhilan Chen Meiling Lu Dandan Zou Hailin Wang; supported by the National Natural Science Foundation of China (No. 20707034, 20877091,20890112, 20921063);the National Basic Research Program (973) of China (No. 09CB421605,2010CB933500, 2011CB936001); An E. coli SOS-EGFP biosensor which expresses enhanced green fluorescent protein as a reporter protein under the control of recA gene promoter in SOS response was constructed for detection of DNA damage and evaluation...; 关键词：bacterial biosensor detection DNA damage GENOTOXINS SOS response

Radiation-induced robust oscillation and non-Gaussian fluctuation: 《Chinese Physics B》2011年第12期465-468,共4页刘波晏世伟耿轶钊; Project supported by the National Natural Science Foundation of China (Grant No. 10975019);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Personnel of China (Grant No. MOP2006138);the Fundamental Research Funds for the Central Universities;the Science Foundation of the Ministry of Science and Technology of China (Grant No. 2012CB934001); There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can r...; 关键词：nuclear radiation DNA damage non-Gaussian activity ROBUSTNESS

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