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DNA_DAMAGE: 作品数：397被引量：1149H指数：14; 导出分析报告; 相关作者：黄百渠张瑜刘松陆军孙晋渊更多>>; 相关机构：东北师范大学首都师范大学上海交通大学医学院附属新华医院浙江林学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金中国博士后科学基金更多>>

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling被引量：13: 《Cell Research》2018年第8期833-854,共22页Pengli Zheng Qingzhou Chen Xiaoyu Tian Nannan Qian Peiyuan Chai Bing Liu Junjie Hu Craig Blackstone Desheng Zhu Junlin Teng Jianguo Chen; We thank Dr. Wenling Han at the School of Basic Medical Sciences, Peking University for kindly providing PANC1, AsPC1, BxPc3 and Mia PaCa 2 cells; Dr. Jingwei Xiong at the Institute of Molecular Medicine of Peking University for providing Cas9 and gRNA plasmids; Dr. Yulong Li at the College of Life Sciences of Peking University for providing the mTagBFP2, R-GECO12 and GCaMP6s plasmids; Dr. Qi Ouyang at the Center for Quantitative Biology of Peking University for the p53 plasmid; Dr. Victor W. Hsu at Harvard University for anti-β-COP antibody; Dr. Gyorgy Hajnoczky at the Department of Pathology, Anatomy and Cell Biology of Thomas Jefferson University for the coding sequence of yeast U8C6; Chunyan Shah and Ming Ou at the Core Facilities of Life Sciences of Peking University for confocal microscopy imaging and image processing; and Liying Du and Hongxia Lu at the Core Facilities of Life Sciences of Peking University for flow cytometnj and statistical ana｜ys~s. This work was supported by the Nationa｜ Natural Science Foundation of＇China （NSFC）（31671392 and 31471280）, the National Key Research and Development Program of China, Stem Cell and Translational Research （2016YFA0100501）, and the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, US National institutes of Health.; The endoplasmic reticulum （ER） is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinat...; 关键词：APOPTOSIS Endoplasmic reticulum MITOCHONDRIA

Spontaneous DNA damage propels tumorigenicity: 《Cell Research》2017年第6期720-721,共2页Ilio Vitale Guido Kroemer; High levels of endogenously gen- erated DNA damage drive oncogen- esis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additiona...; 关键词：DNA损伤损伤机制双链断裂性基因侵袭性恶性细胞

DNA damage and gene transcription： accident or necessity？: 《Cell Research》2015年第7期769-770,共2页Miguel Beato Roni H Wright Guillermo P Vicent; The extent to which DNA repair machinery facilitates gene activation remains poorly appreciated. A new study published in Cell Research reports a novel function of H2AX, a substrate of ATM and known DNA damage marker,...; 关键词：DNA损伤脱氧核糖核酸基因转录基因激活转录起始标志物 ATM 细胞

High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX被引量：5: 《Cell Research》2015年第7期837-850,共14页Indrabahadur Singh Nihan Ozturk Julio Cordero Aditi Mehta Diya Hasan Claudia Cosentino Carlos Sebastian Marcus Kruger Mario Looso Gianni Carraro Saverio Bellusci Werner Seeger Thomas Braun Raul Mostoslavsky Guillermo Barreto; The eukaryotic genome is organized into chromatins, the physiological template for DNA-dependent processes including replication, recombination, repair, and transcription. Chromatin-mediated transcription regulation i...; 关键词：HMGA2 Γ-H2AX TGFΒ1 ATM Gata6 transcription chromatin-associated proteins DNA damage

p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage被引量：4: 《Cell Research》2015年第3期351-369,共19页Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen; The inhibitory role of p53 in DNA double-strand break （DSB） repair seems contradictory to its tumor-suppressing property. The p53 isoform △113p53/△133p53 is a p53 target gene that antagonizes p53 apoptotic activit...; 关键词：p53 isoform △113p53/△133p53 NHEJ HR SSA cell death SENESCENCE

The mlNO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability被引量：1: 《Cell Research》2013年第12期1396-1413,共18页Jin-Na Min Yanyan Tian Yang Xiao Ling Wu Lei Li Sandy Chang; The INO80 （inositol requiring mutant 80） chromatin remodeling complex plays important roles in transcriptional regulation and DNA replication and repair, and consists of several functional protein subunits, includin...; 关键词：DNA damage TELOMERE CANCER genome instability CHROMATIN REPLICATION

The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage被引量：47: 《Cell Research》2013年第3期340-350,共11页Ali Zhang Nanjiang Zhou Jianguo Huang Qian Liu Koji Fukuda Ding Ma Zhaohui Lu Cunxue Bai Kounosuke Watabe Yin-Yuan Mo; It is well known that upon stress, the level of the tumor suppressor p53 is remarkably elevated. However, despite extensive studies, the underlying mechanism involving important inter-players for stress-induced p53 re...; 关键词：lncRNA P53 hnRNPI

K48-1inked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites被引量：7: 《Cell Research》2012年第8期1221-1223,共3页Frederick A Mallette; Efficient DNA damage sensing and repair is crucial to preserve genomic integrity and failure to detect or repair DNA breaks can cause mutations, contributing to the formation of tumors. One key protein required for me...; 关键词：DNA损伤蛋白降解泛素化 DNA修复肿瘤抑制 DNA断裂蛋白质降解基因突变

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy被引量：10: 《Cell Research》2012年第7期1181-1198,共18页Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver; In response to nutrient stress, cells start an autophagy program that can lead to adaptation or death. The mechanisms underlying the signaling from starvation to the initiation of autophagy are not fully understood. I...; 关键词：STARVATION AUTOPHAGY DNA damage PAP P-1 mTOR AMPK

A distinct response to endogenous DNA damage in the development of Nbsl-deficient cortical neurons被引量：2: 《Cell Research》2012年第5期859-872,共14页Rui Li Yun-Gui Yang Yunzhou Gao Zhao-Qi Wang Wei-Min Tong; Microcephaly is a clinical characteristic for human nijmegen breakage syndrome （NBS, mutated in NBS1 gene）, a chromosomal instability syndrome. However, the underlying molecular pathogenesis remains elusive. In the ...; 关键词：DNA damage response Nbsl MICROCEPHALY p53 Hzf

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