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AIM: To explore whether nicotinamide adenine dinucleotide phosphate(NADPH) oxidase 2(NOX2) is expressed in fungal keratitis in mice and investigate its role in this disease.METHODS: NOX2 expression was detected in C57...
Supported by the National Natural Science Foundation of China(No.81870632);the Youth National Natural Science Foundation of China(No.81700800,No.81800800);the Natural Science Foundation of Shandong Province(No.ZR2019BH004,No.ZR2017MH008,No.ZR2017BH025).
●AIM:To observe the expression and role of aryl hydrocarbon receptor(Ah R)in the immune response of mouse cornea infected with Aspergillus fumigatus(A.fumigatus).●METHODS:Murine models of A.fumigatus keratitis were ...
supported by the Natural Science Foundation of Hebei Province(No.H2013206316).
Objective:Invasive pulmonary Aspergillus infection has the characteristics of high morbidity,difficult to be treated,poor prognosis and high mortality.This study aims to investigate the effects of cinnamaldehyde on 1...
Pulmonary alveolar proteinosis (PAP) poses a risk of opportunistic infections with a variety of organisms with Nocardia being the most common pathogen followed by mycobacteria and fungi. Case presentation: A 7-year-ol...
Supported by the National Natural Science Foundation of China(No.81470609; No.81500695; No.81700800; No.81870632; No.81800800);Natural Science Foundation of Shandong Province(No.ZR2017BH025; No.ZR2017MH008; No.ZR2013HQ007)
AIM: To investigate the inflammatory amplification effect of high-mobility group box 1(HMGB1) in Aspergillus fumigatus(A. fumigatus) keratitis and the relationship between lectin-like oxidized low-density lipoprotein ...
Supported by the National Natural Science Foundation of China (No.81470609; No.81500695; No.81700800; No.81870632; No.81800800);Natural Science Foundation of Shandong Province (No.ZR2017BH025; No.ZR2017MH008; No.ZR2013HQ007)
AIM: To determine the disparate expression of autophagy in the Aspergillus fumigatus(A. fumigatus) keratitis between susceptible C57 BL/6 mice and resistant BALB/c mice.METHODS: C57 BL/6 and BALB/c mice were used to e...
Supported by National Natural Science Foundation of China (No.81470609; No.81870632);Youth Project of National Natural Science Foundation of China (No.81500695; No.81700800; No.81800800);Natural Science Foundation of Shandong Province (No.ZR2017MH008);Youth Project of Natural Science Foundation of Shandong Province (No.ZR2013HQ007);Doctor Project of Natural Science Foundation of Shandong Province (No.ZR2017BH025)
AIM: To investigate the expression of macrophage migration inhibitory factor(MIF) and detect its role in the innate immune response of fungal keratitis(FK). METHODS: We collected the paraffin-embedded cornea tissues f...
Supported by the National Natural Science Foundation of China(No.81470609; No.81700800; No.81870632; No.81800800);Natural Science Foundation of Shandong Province(No.ZR2013HQ007; No.ZR2017MH008; No.ZR2017BH025);the Youth National Natural Science Foundation of China(No.81500695)
AIM: To investigate the expression of interleukin(IL)-33 in the cornea and human corneal epithelial cells(HCECs) exposed to Aspergillus fumigatus(A. fumigatus), and to determine the function of IL-33/ST2/p38 signaling...