云南高校图书馆联盟文献共享服务平台- IPSC

IPSC: 作品数：113被引量：156H指数：6; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：李长明全仁夫吴寿海赵士杰王拓更多>>; 相关机构：菲特治疗公司浙江大学呈诺再生医学科技(珠海横琴新区)有限公司北京协和医学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划浙江省医药卫生科学研究基金广西壮族自治区自然科学基金更多>>

HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs被引量：4: 《Science China(Life Sciences)》2021年第9期1449-1462,共14页Jian-Ping Zhang Zhi-Xue Yang Feng Zhang Ya-Wen Fu Xin-Yue Dai Wei Wen Beldon Zhang Hannah Choi Wanqiu Chen Meredith Brown David Baylink Lei Zhang Hongyu Qiu Charles Wang Tao Cheng Xiao-Bing Zhang; supported by the National Natural Science Foundation of China(81870149,82070115,81770198,81700184,81570164,81861148029,81700183,81421002,81890990,81730006);National Key Research and Development Program of China(2019YFA0110803,2019YFA0110204,2016YFA0100600,2017YFA0103400);CAMS Innovation Fund for Medical Sciences(CIFMS)(2017-I2M-B&R-04,2019-I2M-1-006,2017-I2M-1-015,2016-I2M-1-017,2017-I2M-2-001);Ministry of Science and Technology of China(2015CB964902,2015CB964400);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2018PT31004);CAMS Key Laboratory of Gene Therapy for Blood Diseases(2017PT31047,2018PT31038);American Heart Association(18IPA34170301)。; Genome-edited human induced pluripotent stem cells(iPSCs)hold great promise for therapeutic applications.However,low editing efficiency has hampered the applications of CRISPR-Cas9 technology in creating knockout and ...; 关键词：HDAC inhibitors CRISPR-Cas9 genome editing IPSC

Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2被引量：5: 《Science China(Life Sciences)》2016年第11期1131-1138,共8页Pengyan Li Mo Li Xihe Tang Shuyan Wang Y.Alex Zhang Zhiguo Chen; supported by the Stem Cell and Translation National Key Project(2016ZY05002449);National Basic Research Program of China(2011CB965103,2012CBA01307);National Natural Science Foundation of China(81661130160,81422014,81561138004);Beijing Municipal Natural Science Foundation(5142005);Royal Society-Newton Advanced Fellowship(NA150482); Oligodendrocyte progenitor cells(OPCs) hold great promise for treatment of dysmyelinating disorders, such as multiple sclerosis and cerebral palsy. Recent studies on generation of human OPCs mainly use human embryonic...; 关键词：oligodendrocyte progenitors IPSC DIFFERENTIATION DEMYELINATION

Towards Personalized Intervention for Alzheimer's Disease: 《Genomics, Proteomics & Bioinformatics》2016年第5期289-297,共9页Xing Peng Peiqi Xing Xiuhui Li Ying Qian Fuhai Song Zhouxian Bai Guangchun Han Hongxing Lei; supported by the National High-tech R&D Program of China (863 Program;Grant No.2015AA020108);the National Basic Research Program of China (973 Program;Grant No.2014CB964901) funded by the Ministry of Science and Technology of China; Alzheimer＇s disease （AD） remains to be a grand challenge for the international community despite over a century of exploration. A key factor likely accounting for such a situation is the vast heterogeneity in the d...; 关键词：Alzheimer＇s disease Demographic information GENOME Peripheral biomarkers iPSC technology

诱导表达型miR-302s敲入小鼠的构建及表型分析被引量：1: 《中国细胞生物学学报》2016年第8期997-1003,共7页杨桦倪良荣万颖寒周云鹤费俭; 国家重点基础研究发展计划(批准号:2011CB965103);上海市科委项目基金(批准号:14140904300)资助的课题~~; 诱导型多能干细胞(induced pluripotent stem cell,i PSC)是干细胞治疗的重要手段。以过表达miR-302s制备i PSC的方法因兼备较高的诱导效率和较低的成瘤潜能,具有良好的应用前景。为综合评价体内miR-302s过表达的生物学效应以及且为临...; 关键词：miR-302s IPSC 诱导表达敲入模型

Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model被引量：2: 《Neuroscience Bulletin》2015年第4期445-451,共7页Dan-Jing Yang Liang Zhu Jie Ren Rong-Jie Ma Hongwen Zhu Jun Xu; supported by the Ministry of Science and Technology of China (2011CB966200);the National Natural Science Foundation of China (81401053,31471029,81461138037,and 81472141);the National Program for Support of Top-notch Young Professionals;the Program for Young Excellent Talents in Tongji University (2014KJ049);the Public Health Bureau of Tianjin Municipality,China (13KG127); Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating evidence supports the hypothesis that dysfunction of autophagy, leading to an imbalance of proteos...; 关键词：motor neuron disease IPSC AUTOPHAGY amyotrophic lateral sclerosis spinal muscular atrophy

2种诱导iPSC向神经干细胞分化方法的比较被引量：3: 《中国病理生理杂志》2015年第1期188-192,共5页杨坦刘华汪运山; 973计划资助项目(No.2012CB966503;No.2012CB966504);国家青年科学基金资助项目(No.81200950); 目的:整体比较2种促进诱导性多能干细胞(induced pluripotent stem cells,i PSC)向神经干细胞(neural stem cells,NSC)分化的方法,确定一种稳定、高效的获得NSC的方法,并对NSC进行系统鉴定。方法:方法A:SB431542和drosomophorin的浓度均...; 关键词：诱导性多能干细胞分化神经干细胞

Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell selfrenewal and somatic cell reprogramming被引量：8: 《Cell Research》2014年第9期1121-1136,共16页Guofang Chen Xinxiu Xu Lihong Zhang Yanbin Fu Min Wang Haifeng Gu Xin Xie; Maintaining the self-renewal of embryonic stem cells （ESCs） could be achieved by activating the extrinsic signaling, i.e., the use of leukemia inhibitory factor （LIF）, or blocking the intrinsic differentiation pat...; 关键词：SUNITINIB Sutent embryonic stem cell SELF-RENEWAL IPSC VEGF AUTOCRINE

Clinical Therapy Using iPSCs:Hopes and Challenges被引量：4: 《Genomics, Proteomics & Bioinformatics》2013年第5期294-298,共5页Xiao Lu Tongbiao Zhao; supported by grants from the National Basic Research Program of China(Grant No.2012CB966901);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA01040108);the National Natural Science Foundation of China(Grant No.31271592) to TZ; Induced pluripotent stem cells （iPSCs） are generated by ectopic expression of defined transcription factors in somatic cells. They can undergo unlimited self-renewal and maintain the embryonic stem cells （ESCs）-li...; 关键词：IPSC Regenerative medicineDisease modeling IMMUNOGENICITY Tumorigenicity

诱导性多能干细胞免疫原性的发生机制与干预对策被引量：4: 《中国细胞生物学学报》2013年第4期410-416,共7页王娅婕郝莎袁卫平程涛; 国家医药重大专项(批准号:2011ZX09102-010-04);国家重点基础研究发展计划(973)项目(批准号:2010CB945204;2012CB966600);科技部国际合作计划(批准号:2010DFB30270)资助的课题~~; 诱导性多能干细胞(iPSC)技术为再生医学开辟了一条广阔而富有前景的新途径。但近期对于自体来源的iPSC及其分化细胞免疫原性的研究结果存在争议,因此研究影响iPSC免疫原性的因素、机体对其可能的免疫排斥及相关免疫耐受机制是未来实现i...; 关键词：诱导性多能干细胞(iPSC) 免疫原性免疫耐受再生医学

线粒体对iPSC再程序化的影响: 《基础医学与临床》2013年第3期374-377,共4页贺文凤曹青洪葵; 教育部创新团发展计划(IRT1141);国家973项目(2007CB512002); iPS技术的出现为研究疾病的发病机制、药物筛选以及再生医学提供了新的途径。尽管iPS技术取得了迅速的发展,但对于iPS重编程过程目前仍不清楚。线粒体是细胞的多种生理过程的重要参与者,而其与iPS再程序化过程有什么联系,起到什么样的...; 关键词：IPS 线粒体再程序化

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