IRRITABLE

作品数：153被引量：1654H指数：17
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相关领域：医药卫生更多>>
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相关机构：首都医科大学附属北京中医医院中华中医药学会中国中医科学院望京医院河北北方学院附属第二医院更多>>
相关期刊：《Psychosomatic Medicine Research》《Chinese Medical Journal》《外科研究与新技术（中英文）》《Precision Medicine Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome: Associations with abdominal pain, visceral hypersensitivity and psychological performance被引量：15
《World Journal of Clinical Cases》2020年第9期1632-1641,共10页Geng Qin Yu Zhang Shu-Kun Yao 
Supported by the National Key Technology Support Program during “12th Five-Year Plan”period of China,No.2014BAI08B00;the Leapforward Development Program for Beijing Biopharmaceutical Industry(G20),No. Z171100001717008.
BACKGROUND Visceral hypersensitivity and psychological performance are the main pathophysiological mechanisms of irritable bowel syndrome(IBS).Previous studies have found that cholecystokinin(CCK)can enhance colon mov...
关键词：IRRITABLE bowel syndrome Abdominal pain VISCERAL HYPERSENSITIVITY Psychological performance SEROTONIN TRANSPORTER CHOLECYSTOKININ 
Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome被引量：10
《World Journal of Gastroenterology》2019年第43期6416-6429,共14页Wen-Xue Zhang Yu Zhang Geng Qin Kai-Min Li Wei Wei Su-Yun Li Shu-Kun Yao 
the National Key Technology Support Program for the “12th Five-Year Plan” of China,No.2014BAI08B00;the Research Projects on Biomedical Transformation of China-Japan Friendship Hospital,No.PYBZ1815
BACKGROUND Fecal metabolites are associated with gut visceral sensitivity,mucosal immune function and intestinal barrier function,all of which have critical roles in the pathogenesis of irritable bowel syndrome(IBS).H...
关键词：FECAL metabolite IRRITABLE bowel syndrome Amino ACIDS Organic ACIDS Short chain fatty ACIDS VISCERAL HYPERSENSITIVITY 
Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome被引量：51
《World Journal of Gastroenterology》2019年第32期4696-4714,共19页Chun-Hui Bao Chun-Ye Wang Guo-Na Li Yi-Lu Yan Di Wang Xiao-Ming Jin Lu-Yi Wu Hui-Rong Liu Xiao-Mei Wang Zheng Shi Huan-Gan Wu 
Supported by the National Natural Science Foundation of China,No.81503656;the National Key Basic Research Program of China(973 Program),No.2015CB554501 and No.2009CB522900
BACKGROUND About one-third of refractory irritable bowel syndrome(IBS)cases are caused by gastrointestinal(GI)infection/inflammation,known as post-infectious/postinflammatory IBS(PI-IBS).Although it is known that inte...
关键词：Moxibustion Post-inflammation IRRITABLE bowel syndrome INTESTINAL microbes NLRP6 INFLAMMASOME INTESTINAL INFLAMMATION Visceral HYPERSENSITIVITY Traditional Chinese medicine 
Effect of the interleukin 10 polymorphisms on interleukin 10 production and visceral hypersensitivity in Chinese patients with diarrhea-predominant irritable bowel syndrome被引量：6
《Chinese Medical Journal》2019年第13期1524-1532,共9页Shi-Wei Zhu Zuo-Jing Liu Qing-Hua Sun Li-Ping Duan 
grants from the National Natural Science Foundation of China(No.81670491);National“Twelfth Five-Year”Plan for Science and Technology of China(No.2012BAI06B02).
Background:Irritable bowel syndrome (IBS),a functional gastrointestinal disorder,is characterized by cytokine imbalance.Previously,decreased plasma interleukin 10 (IL-10) level was reported in patients with IBS,which ...
关键词：IRRITABLE BOWEL syndrome INTERLEUKIN 10 POLYMORPHISMS VISCERAL HYPERSENSITIVITY Depression 
Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrheapredominant irritable bowel syndrome被引量：17
《World Journal of Gastroenterology》2019年第2期269-281,共13页Yu Zhang Geng Qin De-Rong Liu Yan Wang Shu-Kun Yao 
Supported by the National Key Technology Support Program during "12th Five-Year Plan"Period of China,No.2014BAI08B00;the Leapforward Development Program for Beijing Biopharmaceutical Industry(G20),No.Z171100001717008
BACKGROUND Visceral hypersensitivity is considered to play a vital role in the pathogenesis of irritable bowel syndrome(IBS). Neurotrophins have drawn much attention in IBS recently. Brain-derived neurotrophic factor(...
关键词：IRRITABLE bowel syndrome DIARRHEA BRAIN-DERIVED NEUROTROPHIC factor VISCERAL HYPERSENSITIVITY Nerve growth 
Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome被引量：10
《World Journal of Gastroenterology》2018年第1期46-57,共12页De-Rong Liu Xiao-Juan Xu Shu-Kun Yao 
Supported by National key Technology Support Program during the"12th Five-Year Plan"Period of China,No.2014BAI08B02
AIM To measure the leptin levels in patients with diarrheapredominant irritable bowel syndrome(IBS-D) and analyze the relationship of leptin with clinical features, visceral sensitivity, mast cells, and nerve fibers. ...
关键词：Leptin IRRITABLE bowel syndrome MAST cells DIARRHEA VISCERAL HYPERSENSITIVITY 
Preinduced intestinal HSP70 improves visceral hypersensitivity and abnormal intestinal motility in PI-IBS mouse model被引量：8
《Asian Pacific Journal of Tropical Medicine》2016年第3期297-300,共4页Cheng Lan Xiao-Ning Sun Xu-Chun Zhou Bo Yang Bai-Li Huang Tao-Zhi Deng Zhou-Tao He Xiang-Yang Han 
supported by Natural Science Foundation of China Grant(No.81160057):International Science and Technique Corporation Foundation of Hainan Province Grant(No.KJHZ2013-14)
Objective:To investigate the impact of the preinduced intestinal heat shock protein 70(HSP70)on the visceral hypersensitivity and abnormal intestinal motility in a post-infectious irritable bowel syndrome(PI-IBS) mous...
关键词：Post-infectious IRRITABLE bowel syndrome Heat shock protein 70 PROINFLAMMATORY cytokine VISCERAL HYPERSENSITIVITY INTESTINAL MOTILITY 
TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity被引量：14
《World Journal of Gastroenterology》2015年第28期8615-8628,共14页Bo Yuan Wei-Hong Tang Li-Juan Lu Yuan Zhou Hong-Yan Zhu You-Lang Zhou Hong-Hong Zhang Chuang-Ying Hu Guang-Yin Xu 
Supported by National Natural Science Foundation of China,No.81230024,No.81471137(to GYX)and No.31400947(to HHZ);Priority Academic Program Development of Jiangsu Higher Education Institutions
AIM:To investigate the roles of toll-like receptor 4(TLR4) and nuclear factor(NF)-κB on cystathionine βsynthetase(CBS) expression and visceral hypersensitivity in rats.METHODS:This study used 1-7-wk-old male Sprague...
关键词：IRRITABLE BOWEL syndrome DORSAL rootganglion VISCERAL HYPERSENSITIVITY Hydrogen sulfide TOLL-LIKE receptors Nuclear factor-kappa B 
Probiotics and irritable bowel syndrome被引量：14
《World Journal of Gastroenterology》2013年第36期5973-5980,共8页Cong Dai Chang-Qing Zheng Min Jiang Xiao-Yu Ma Li-Juan Jiang 
Irritable bowel syndrome(IBS)is common gastrointestinal problems.It is characterized by abdominal pain or discomfort,and is associated with changes in stool frequency and/or consistency.The etiopathogenesis of IBS may...
关键词：PROBIOTICS IRRITABLE BOWEL syndrome VISCERAL HYPERSENSITIVITY Brain-gut axis Immune function 
Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome被引量：10
《World Journal of Gastroenterology》2013年第35期5787-5797,共11页Nicola de Bortoli Irene Martinucci Massimo Bellini Edoardo Savarino Vincenzo Savarino Corrado Blandizzi Santino Marchi 
Several studies indicate a significant degree of overlap between irritable bowel syndrome(IBS)and gastroesophageal reflux disease(GERD).Likewise,both functional heartburn(FH)and IBS are functional digestive disorders ...
关键词：Functional gastrointestinal disorders GASTROESOPHAGEAL REFLUX disease/Gastro-oesophageal REFLUX DISEASE IRRITABLE bowel syndrome Acidity(esophageal) HYPERSENSITIVITY 
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