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医药卫生—外科学: 作品数：1651844被引量：2204498H指数：248; 导出分析报告; 相关作者：贾连顺杨述华邱勇徐永清张英泽更多>>; 相关机构：第二军医大学华中科技大学复旦大学中国人民解放军总医院更多>>; 发文主题：手术治疗并发症疗效观察腹腔镜临床疗效更多>>; 相关期刊：更多>>; 发文基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划广东省科技计划工业攻关项目更多>>

Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway被引量：3: 《Neural Regeneration Research》2024年第2期434-439,共6页Chenxi Zhao Tiangang Zhou Ming Li Jie Liu Xiaoqing Zhao Yilin Pang Xinjie Liu Jiawei Zhang Lei Ma Wenxiang Li Xue Yao Shiqing Feng; supported by the Key Project of the National Natural Science Foundation of China,No.81930070(to SF);the National Natural Science Foundation of China,No.81972074(to XY);the Key Program of Natural Science Foundation of Tianjin,No.19JCZDJC34900(to XY)。; Argatroban is a synthetic thrombin inhibitor approved by U.S.Food and Drug Administration for the treatment of thrombosis.However,whether it plays a role in the repair of spinal cord injury is unknown.In this study,we...; 关键词：ARGATROBAN ASTROGLIOSIS JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury THROMBIN vimentin

Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment被引量：2: 《Neural Regeneration Research》2024年第2期440-446,共7页Sumei Liu Baoguo Liu Qian Li Tianqi Zheng Bochao Liu Mo Li Zhiguo Chen; supported by the Stem Cell and Translation National Key Project,No.2016YFA0101403(to ZC);the National Natural Science Foundation of China,Nos.82171250 and 81973351(to ZC);the Natural Science Foundation of Beijing,No.5142005(to ZC);Beijing Talents Foundation,No.2017000021223TD03(to ZC);Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan,No.CIT&TCD20180333(to ZC);Beijing Municipal Health Commission Fund,No.PXM2020_026283_000005(to ZC);Beijing One Hundred,Thousand,and Ten Thousand Talents Fund,No.2018A03(to ZC);the Royal Society-Newton Advanced Fellowship,No.NA150482(to ZC);the National Natural Science Foundation of China for Young Scientists,No.31900740(to SL)。; Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate recovery.Only a few studies have attempted to use transplanted cells a...; 关键词：biomaterial FIBRINOGEN functional recovery induced neural stem cell transplantation MICROENVIRONMENT MICROGLIA spinal cord injury THROMBIN

Advances in extracellular vesicle-based combination therapies for spinal cord injury被引量：1: 《Neural Regeneration Research》2024年第2期369-374,共6页Tingting Wang Guohao Huang Zhiheng Yi Sihan Dai Weiduan Zhuang Shaowei Guo; supported by the 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant,No.2020LKSFG02C(to Qiang Fang and SG);the National Natural Science Foundation of China,No.82201511(to SG);the Guangdong Basic and Applied Basic Research Foundation,Nos.2021A1515110873(to SG),2022A1515110139(to TW);the Medical Scientific Research Foundation of Guangdong Province,No.A2022077(to SG)。; Spinal cord injury is a severe insult to the central nervous system that causes persisting neurological deficits.The currently available treatments involve surgical,medical,and rehabilitative strategies.However,none o...; 关键词：BIOMATERIALS combination therapy drug delivery EXOSOMES extracellular vesicles functional recovery HYDROGELS scaffolds spinal cord injury tissue engineering

The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury被引量：1: 《Neural Regeneration Research》2024年第1期22-28,共7页Caiyun Liu Haixin Yu Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen; supported by the Key Projects of the National Natural Science Foundation of China,No.11932013(to XC);Key Military Logistics Research Projects,No.B WJ21J002(to XC);the Key projects of the Special Zone for National Defence Innovation,No.21-163-12-ZT006002-13(to XC);the National Nature Science Foundation of China No.82272255(to XC);the National Defense Science and Technology Outstanding Youth Science Fund Program,No.2021-JCIQ-ZQ-035(to XC);the Scientific Research Innovation Team Project of Armed Police Characteristic Medical Center,No.KYCXTD0104(to ZL);the National Natural Science Foundation of China Youth Fund,No.82004467(to BC)。; Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hi...; 关键词：artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice被引量：1: 《Neural Regeneration Research》2024年第1期171-179,共9页Weilin Tan Jun Ma Jiayuanyuan Fu Biying Wu Ziyu Zhu Xuekang Huang Mengran Du Chenrui Wu Ehab Balawi Qiang Zhou Jie Zhang Zhengbu Liao; supported by the National Natural Science Foundation of China,No.81771355;the Natural Science Foundation of Chongqing Science and Technology Bureau,Nos.CSTC2015jcyjA10096,cstc2021jcyj-msxmX0262(all to ZL)。; Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate trau...; 关键词：axon guidance bioinformatics analysis competing endogenous RNA ERYTHROPOIETIN Gene Ontology Kyoto Encyclopedia of Genes and Genomes non-coding RNA RNA sequencing transcriptomics traumatic brain injury

Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway被引量：1: 《Neural Regeneration Research》2024年第1期180-189,共10页Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu; supported by the National Natural Science Foundation of China,Nos.81070996(to ZW),81572151(to XH);Shaanxi Provincial Key R&D Program,Nos.2020ZDLSF02-05(to ZW),2021ZDLSF02-10(to XH);Everest Project of Military Medicine of Air Force Medical University,No.2018RCFC02(to XH);Boosting Project of the First Affiliated Hospital of Air Force Medical University,No.XJZT19Z22(to ZW)。; Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins ...; 关键词：chondroitin sulfate proteoglycans Erk MAPK P38 PHOTOBIOMODULATION principal component analysis SMAD3 SOX9 spinal cord injury VERSICAN

Quantitative proteomic and phosphoproteomic analyses of the hippocampus reveal the involvement of NMDAR1 signaling in repetitive mild traumatic brain injury被引量：1: 《Neural Regeneration Research》2023年第12期2711-2719,共9页Zhicheng Tian Zixuan Cao Erwan Yang Juan Li Dan Liao Fei Wang Taozhi Wang Zhuoyuan Zhang Haofuzi Zhang Xiaofan Jiang Xin Li Peng Luo; funded by the National Natural Science Foundation of China,Nos.82171363(to PL),82171321(to XL),82171458(to XJ);the Youth Nova Program of Shaanxi,No.2021KJXX-19(to PL)。; The cumulative damage caused by repetitive mild traumatic brain injury can cause long-term neurodegeneration leading to cognitive impairment.This cognitive impairment is thought to result specifically from damage to t...; 关键词：cognitive impairment Grin1 HIPPOCAMPUS learning memory N-METHYL-D-ASPARTATE N-methyl-D-aspartate receptor 1 phosphoproteomic PROTEOMIC repetitive mild traumatic brain injury(rmTBI) secondary injury

Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury被引量：1: 《Neural Regeneration Research》2023年第12期2727-2732,共6页Chao Ma Junpei Wang Qifeng Tu Weijuan Bo Zunlu Hu Run Zhuo Ronghua Wu Zhangji Dong Liang Qiang Yan Liu Mei Liu; the National Natural Science Foundation of China,Nos.32070725(to ML),82001295(to RHW),31970412(to YL);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions。; Fidgetin,a microtubule-severing enzyme,regulates neurite outgrowth,axonal regeneration,and cell migration by trimming off the labile domain of microtubule polymers.Because maintenance of the microtubule labile domain ...; 关键词：acetylated microtubules axon regeneration axonal branching axonal regrowth end binding protein 3 fidgetin microtubule dynamics sciatic nerve injury spinal cord injury tyrosinated microtubules

A novel mouse model of central cord syndrome: 《Neural Regeneration Research》2023年第12期2751-2756,共6页Elzat Elham-Yilizati Yilihamu Xiangchuang Fan Zimeng Yang Shiqing Feng; the National Key Research and Development Project of Stem Cell and Transformation Research,No.2019YFA0112100;the National Natural Science Foundation of China(Key Program),No.81930070(both to SF)。; Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma.Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries.In this study,we...; 关键词：animal model BEHAVIOR central cord syndrome cervical spinal cord injury cervical spinal cord PATHOLOGY preclinical research spinal cord spinal cord compression spinal cord injury

Nerve function restoration following targeted muscle reinnervation after varying delayed periods: 《Neural Regeneration Research》2023年第12期2762-2766,共5页Yuanheng Li Jiangping Huang Yuling Chen Shanshan Zhu Zhen Huang Lin Yang Guanglin Li; supported in part by the National Natural Science Foundation of China,Nos.U1913601,81927804;the Key-Area Research and Development Program of Guangdong Province,No.2020B0909020004(GL);the National Natural Science Foundation of China,Nos.81960419,82260456(both to LY)。; Targeted muscle reinnervation has been proposed for reconstruction of neuromuscular function in amputees.However,it is unknown whether performing delayed targeted muscle reinnervation after nerve injury will affect re...; 关键词：biceps brachii delayed nerve repair delayed targeted muscle reinnervation functional reconstruction grooming test implanted electrode intramuscular myoelectric signals median nerve motor function nerve transfer

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