医药卫生—药学

作品数：728887被引量：1325817H指数：152
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相关作者：赵志刚王睿马双成葛卫红胡昌勤更多>>
相关机构：中国药科大学沈阳药科大学华中科技大学复旦大学更多>>
发文主题：合理用药高效液相色谱法抗菌药物药物药品更多>>
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发文基金：国家自然科学基金国家科技重大专项国家高技术研究发展计划国家重点基础研究发展计划更多>>
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Inhibition of histone methyltransferase PRMT5 attenuates cisplatininduced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway被引量：1
《Journal of Pharmaceutical Analysis》2023年第6期590-602,共13页Zhiwei Zheng Benyu Nan Chang Liu Dongmei Tang Wen Li Liping Zhao Guohui Nie Yingzi He 
supported by grants from the National Natural Science Foundation of China(Grant Nos.:82271158,82192865,and 82071045);Wenzhou Municipal Science and Technology Research Program(Grant No.:2021Y0681).
This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5(PRMT5)in cisplatin-induced hearing loss.The effects of PRMT5 inhibition on cisplatin-induced auditory injury we...
关键词：Protein arginine methyltransferase 5 (PRMT5) LLY-283 CISPLATIN Hearing loss Hair cell Spiral ganglion neuron 
Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically
《Journal of Pharmaceutical Analysis》2023年第6期603-615,共13页Liuyun Gong Yinliang Lu Jing Wang Xinyue Li Jing Zhao Yuetong Chen Rongze Ma Jinlu Ma Tianya Liu Suxia Han 
supported by the National Natural Science Foundation of China(Grant Nos.:81272488 and 81602802);the Shaanxi Province Innovation Capacity Support Program(Grant No.:2018TD-002).
Intensive cancer treatment with drug combination is widely exploited in the clinic but suffers from inconsistent pharmacokinetics among different therapeutic agents.To overcome it,the emerging nanomedicine offers an u...
关键词：Liver cancer Drug combination Cancer therapy ATR inhibitor XPO1 inhibitor 
Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines,anti-PD-1 and poly I:C被引量：1
《Journal of Pharmaceutical Analysis》2023年第6期616-624,共9页Ping Zhu Shi-You Li Jin Ding Zhou Fei Sheng-Nan Sun Zhao-Hui Zheng Ding Wei Jun Jiang Jin-Lin Miao San-Zhong Li Xing Luo Kui Zhang Bin Wang Kun Zhang Su Pu Qian-Ting Wang Xin-Yue Zhang Gao-Liu Wen Jun OLiu John Thomas August Huijie Bian Zhi-Nan Chen You-Wen He 
supported by Natural Science Foundation of Shaanxi Province(Grant No.:2019ZY-CXPT-03-01)to Ping Zhu and Key Research and Development Program of Shaanxi Province(Grant No.:2020ZDLSF03-02)to Zhi-Nan Chen and Huijie Bian as well as Tricision Biotherapeutics Inc.
Glioblastoma(GBM)is a lethal cancer with limited therapeutic options.Dendritic cell(DC)-based cancer vaccines provide a promising approach for GBM treatment.Clinical studies suggest that other immunotherapeutic agents...
关键词：Glioblastoma multiforme DC vaccine Tumor-associated antigens Neoantigens 
Tumor cell membrane-coated continuous electrochemical sensor for GLUT1 inhibitor screening
《Journal of Pharmaceutical Analysis》2023年第6期673-682,共10页Jiaqian Zhao Yuqiao Liu Ling Zhu Junmin Li Yanhui Liu Jiarui Luo Tian Xie Dajing Chen 
supported by the National Natural Science Foundation of China,China(Grant Nos.:61801160 and 81730108).
Glucose transporter 1(GLUT1)overexpression in tumor cells is a potential target for drug therapy,but few studies have reported screening GLUT1 inhibitors from natural or synthetic compounds.With current analysis techn...
关键词：Glucose transporter 1 inhibitor Electrochemical sensor Drug screen Traditional Chinese medicine 
Pterostilbene antagonizes homocysteine-induced oxidative stress,apoptosis and lipid deposition in vascular endothelial cells被引量：2
《Food Science and Human Wellness》2023年第5期1683-1692,共10页Qiao Jiang Li Wang Xu Si Yuanyuan Bian Weijia Zhang Huijun Cui Hailong Gui Ye Zhang Bin Li Dehong Tan 
supported by the Zhejiang Lanmei Technology Co.,Ltd.,National Natural Science Foundation of China (U21A20273);“China Agriculture Research System of MOF and MARA (CARS-29)”;the First Batch of Liaoning “Unveiling Leader” Scientific and Technological Projects (2021JH1/10400036)。
Hyperhomocysteinemia(HHcy)causes oxidative stress, induces apoptosis, and leads to damage to the vascular endothelium is the starting point of atherosclerosis. Pterostilbene(Pte)has been reported to have antioxidant a...
关键词：PTEROSTILBENE HYPERHOMOCYSTEINEMIA METHIONINE POLYPHENOLS ATHEROSCLEROSIS 
Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma被引量：4
《Journal of Pharmaceutical Analysis》2023年第5期463-482,共20页Linlin Qu Yannan Liu Jianjun Deng Xiaoxuan Ma Daidi Fan 
supported by the National Key R&D Program of China(Grant No.:2021YFC2101500);the National Natural Science Foundation of China(Grant Nos.:22078264,21978235,22108224,and 21978236);the Natural Science Basic Research Program of Shaanxi,China(Grant Nos.:2023-JC-JQ-17 and 2023-JCQN-0109);the Xi'an Science and Technology Project,China(Project No.:20191422315KYPT014JC016);Key Research and Development Program of Shaanxi,China(Grant No.:2022ZDLSF05-12).
Hepatocellular carcinoma(HCC)is the third leading cause of cancer death worldwide.Ginsenoside Rk3,an important and rare saponin in heat-treated ginseng,is generated from Rg1 and has a smaller molecular weight.However,...
关键词：Hepatocellular carcinoma Ginsenoside Rk3 APOPTOSIS AUTOPHAGY PI3K/AKT pathway 
A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance
《Journal of Pharmaceutical Analysis》2023年第5期514-522,共9页Ying-Qi Song Guo-Dong Li Dou Niu Feng Chen Shaozhen Jing Vincent Kam Wai Wong Wanhe Wang Chung-Hang Leung 
supported by the Science and Technology Development Fund(Grant Nos.:0007/2020/A1 and 0020/2022/A1);the State Key Laboratory of Quality Research in Chinese Medicine,University of Macao(Grant No.:SKL-QRCM(UM)-2020-2022);the University of Macao(Grant Nos.:MYRG2019-00002-ICMS and MYRG2020-00017-ICMS);2022 Internal Research Grant of SKLQRCM(University of Macao)(Grant No.:QRCM-IRG2022-011);the National Natural Science Foundation of China(Grant No.:22101230);the Natural Science Basic Research Program of Shaanxi(Grant No.:2021JQ-089);the Natural Science Foundation of Chongqing,China(Grant No.:cstc2021jcyj-msxmX0659).
Temozolomide(TMZ)is an anticancer agent used to treat glioblastoma,typically following radiation therapy and/or surgical resection.However,despite its effectiveness,at least 50%of patients do not respond to TMZ,which ...
关键词：Drug screening Alkyladenine DNA glycosylase N3-methyladenine GLIOBLASTOMA TEMOZOLOMIDE SUNITINIB 
Degradation of amyloid β-peptides catalyzed by nattokinase in vivo and in vitro
《Food Science and Human Wellness》2023年第5期1905-1916,共12页Aixin Ni He Li Ruya Wang Rentong Sun Yingjiu Zhang 
supported by the National Natural Science Foundation of China Program (No. 31970883)。
Amyloid-β 1-42(Aβ42)plays a pivotal role in Alzheimer disease(AD)pathogenesis. Peripheral clearance of Aβ42 largely affects its level in the brain and affects AD progression. Although nattokinase(NK)degrades Aβ40,...
关键词：NATTOKINASE Amyloidβ-peptide DEGRADATION CATALYZE Alzheimer disease 
The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier被引量：3
《Neural Regeneration Research》2023年第10期2147-2155,共9页Shuang-Shuang Wei Le Chen Feng-Yuan Yang Si-Qi Wang Peng Wang 
supported by the National Natural Science Foundation of China,Nos.82001282(to PW)and 81960232(to PW);Overseas Students’Innovation and Entrepreneurship Individual Project of Ningxia(2021)(to PW);Youth Talents Supporting Program of Ningxia Medical University and Ningxia,Nos.XT2019018(to PW),TJGC2019081(to PW);College Students’Innovation and En trepreneurship Training Program,No.X202210752038(to FYY)。
Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression.Previous research has shown that the extracellular matrix is associated with remyel...
关键词：blood-brain barrier brain delivery EXOSOMES extracellular matrix fibronectin aggregates FIBRONECTIN intestinal flora multiple sclerosis remyelination failure REMYELINATION 
The effect of Pickering emulsion adjuvants on the immune efficacy of the COVID-19 polypeptide vaccine
《ChemPhysMater》2023年第3期259-266,共8页Zhuanqing Huang Qi Sun Haoyuan Shi Sen Yang Yuanyuan Li Yue Ma Fei Yang Zhenwei Shi Yalong Yang Ying Zhang Hui Gong Fenghua Xu 
funded by National Natural Science Foundation of China(82171814).
Pickering emulsions were prepared by phacoemulsification in an ice water bath with squalene as the oil phase and an aluminum adjuvant as the particle stabilizer.The effects of formulation and process conditions on the...
关键词：Pickering emulsions Ultrasonic emulsification Immunologic adjuvant COVID-19 Polypeptide vaccine 
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