云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(81222051)

国家自然科学基金(81222051): 作品数：15被引量：212H指数：7; 导出分析报告; 相关作者：屠鹏飞姜勇吕海宁赵凯薛培凤更多>>; 相关机构：北京大学内蒙古医科大学北京中医药大学浙江中医药大学附属第三医院更多>>; 相关期刊：《Acupuncture and Herbal Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《药学学报》更多>>; 相关主题：肉桂化学成分化学成分研究二萜PATHWAY更多>>; 相关领域：医药卫生生物学更多>>

Baoyuan decoction alleviates myocardial infarction through the regulation of metabolic dysfunction and the mitochondria-dependent caspase-9/3 pathway被引量：2: 《Acupuncture and Herbal Medicine》2021年第1期49-58,共10页Zhiyong Du Zeliu Shu Chun Li Xiaomin Song Xiaoli Ma Lixi Liao Jun Li Pengfei Tu Kewu Zeng Yong Jiang; financially supported by the National Natural Sciences Foundation of China(Nos.81530097 and 81222051);the National Key Technology R&D Program“New Drug Innovation”of China(No.2017ZX09101003-008-003).; Objective:Baoyuan decoction(BYD)is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological tests.The present study aimed to investigate the effect and mechanism of BYD on ...; 关键词：Baoyuan decoction Caspase-9/3 pathway Mechanisms Metabolomics Mitochondrial energy metabolism Myocardial infarction

Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway被引量：4: 《Acta Pharmacologica Sinica》2020年第2期173-180,共8页Yan-hang Wang Hai-ning Lv Qing-hua Cui Peng-fei Tu Yong Jiang Ke-wu Zeng; the National Natural Science Foundation of China(Numbers 81773932,81530097 and 81222051);the Drug Innovation Major Project(Number 2018ZX09711001-008-003).; Microglia-mediated neuroinflammation is a crucial risk factor for neurological disorders.Recently,dopamine receptors have been found to be involved in multiple immunopathological processes and considered as valuable t...; 关键词：isosibiricin natural product NEUROINFLAMMATION DOPAMINE D1/2 receptors inflammatory MEDIATORS NLRP3 INFLAMMASOME PATHWAY

UPLC-Qtrap-MS法分析鉴定肉桂水提物给药后大鼠血浆、胆汁、尿液和粪便中的药源性成分被引量：7: 《中国中药杂志》2019年第21期4720-4727,共8页施梦玲宋月林陈金凤何珊郭晓宇屠鹏飞李军姜勇; 国家自然科学基金项目(81530097,81222051);国家“重大新药创制”科技重大专项(2018ZX09711001-008-003); 研究肉桂水提物主要成分在正常大鼠血浆、胆汁、尿液和粪便中的药源性成分,推测其代谢途径。通过灌胃给予大鼠肉桂水提物后,收集血浆、胆汁、尿液和粪便并进行预处理,采用UPLC-Qtrap-MS技术,综合使用增强型全扫描、母离子扫描、中性丢...; 关键词：肉桂水提物 UPLC-Qtrap-MS 代谢产物原花青素木脂素二萜

真武汤治疗急性心力衰竭的疗效及对患者心功能、心肌细胞凋亡因子和血清脑钠肽的影响被引量：7: 《中国基层医药》2018年第9期1089-1093,共5页史文静杨炜宋佳陈春燕吴斌; 国家自然科学基金项目（81222051）; 目的探讨真武汤治疗急性心力衰竭（AHF）的临床疗效及对患者心功能、心肌细胞凋亡因子和血清脑钠肽（BNP）水平的影响.方法将AHF患者94例纳入研究,依据其就诊时间编号分组,其中单号者47例作为对照组,接受常规西医治疗;双号者47例作为...; 关键词：心力衰竭真武汤心功能细胞凋亡因子利钠肽脑

Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway被引量：23: 《Chinese Journal of Natural Medicines》2017年第10期751-757,共7页YU Qian ZENG Ke-Wu MA Xiao-Li JIANG Yong TU Peng-Fei WANG Xue-Mei; supported by the National Natural Science Foundation of China(Nos.81173369,81303253,81530097,and 81222051);the National Key Technology R&D Program “New Drug Innovation” of China(Nos.2012ZX09301002-002-002 and 2012ZX09304-005);the Natural Science Foundation of Beijing,China(No.132210);the Doctoral Scientific Fund Project of the Ministry of Education of China(No.20120001110105); The saponin ginsenoside Rk1 is a major compound isolated from ginseng.Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism.However,th...; 关键词：Inflammation RAW264.7 cells GINSENOSIDE Rkl JAK2/STAT3 NF-xB

靶向瞬时受体电位通道天然调节剂的研究进展被引量：5: 《药学学报》2017年第5期673-684,共12页曹南开吕海宁卫宁宁李军屠鹏飞王克威姜勇; 国家自然科学基金资助项目(81473106,81222051); 超家族瞬时受体电位(transient receptor potential,TRP)通道是存在于细胞膜上的非选择性阳离子通道,28个成员分为7个亚家族,广泛分布于人体的组织器官内,作为生物感受器参与调节视觉、听觉、味觉、痛觉和触觉等功能。到目前为止,从自...; 关键词：瞬时受体电位通道天然调节剂 TRPV TRPA TRPM TRPC 辣椒素

Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert被引量：9: 《Chinese Journal of Natural Medicines》2016年第1期61-65,共5页NAN Ze-Dong ZHAO Ming-Bo Zeng Ke-Wu TIAN Shuai-Hua WANG Wei-Nan JIANG Yong TU Peng-Fei; financially supported by National Natural Sciences Foundation of China(No.81222051);Scientific Research Project of Traditional Chinese Medicine(No.201307002);National Key Technology R&D Program “New Drug Innovation”of China(Nos.2012ZX09301002-002-002,2012ZX09304-005); In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert,a systematically phytochemical investigation was carried out.The constituents were isolated by silica gel,Sephadex LH-2...; 关键词：CISTANCHE deserticola IRIDOIDS Structure ELUCIDATION Anti—inflammatory activity

A SERIES OF STRATEGIES FOR SOLVING THE SHORTAGE OF REFERENCE STANDARDS FOR MULTI-COMPONENTS DETERMINATION OF TRADITIONAL CHINESE MEDICINE被引量：1: 《World Journal of Traditional Chinese Medicine》2015年第4期90-91,共2页Wenguang Wang Xiaoli Ma Pengfei Tu Yong Jiang; financially supported by National Natural Sciences Foundation of China(No.81222051);National Key Technology R&D Program"New Drug Innovation"of China(No.2012ZX09304-005); The shortage of reference standards has become the bottleneck of quality control of TCMs.In this study,a series of strategies,including one single reference standard to determine multi-compounds(SSDMC),quantitative an...; 关键词：ESM A SERIES OF STRATEGIES FOR SOLVING THE SHORTAGE OF REFERENCE STANDARDS FOR MULTI-COMPONENTS DETERMINATION OF TRADITIONAL CHINESE MEDICINE

肉桂的化学成分研究被引量：30: 《中国中药杂志》2015年第18期3598-3602,共5页何珊姜勇屠鹏飞; 国家自然科学基金项目(81222051);国家"重大新药创制"科技重大专项(2012ZX09301002-002-002;2012ZX09304-005); 采用硅胶柱色谱、ODS反相柱色谱、Sephadex LH-20及制备HPLC等多种色谱分离技术对肉桂乙醇提取物中的化学成分进行分离纯化,运用NMR、MS等波谱方法并结合已有文献对分离得到的化合物进行结构鉴定。结果从肉桂的乙醇提取物中分离得到12...; 关键词：肉桂化学成分黄烷醇芳香化合物结构鉴定

Simultaneous determination of three main analytes of Murraya exotica by HPLC被引量：3: 《Journal of Chinese Pharmaceutical Sciences》2015年第2期88-94,共7页刘冰语章宸吕海宁屠鹏飞邢建永韩正洲姜勇; National Natural Science Foundation of China(Grant No.81222051 and 81473106);National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2012ZX09301002-002-002 and 2012ZX09304-005); Murraya exotica L. is one of the two official source species of traditional Chinese medicine Murrayae Folium et Cacumen. At present, a rapid HPLC analysis method to simultaneously determine two major coumarins, hainan...; 关键词：Murraya exotica L. COUMARIN Flavonoid Quantification HPLC

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

国家自然科学基金(81222051)

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

国家自然科学基金(81222051)

检索结果分析

下载全文

用户登录

高级检索检索式检索