高等学校学科创新引智计划(China)

作品数：28被引量：204H指数：8
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Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome被引量：5
《Acta Pharmaceutica Sinica B》2023年第5期2176-2187,共12页Chuan Hu Yujun Song Yiwei Zhang Siqin He Xueying Liu Xiaotong Yang Tao Gong Yuan Huang Huile Gao 
the National Natural Science Foundation of China(82173762,China);111 Project(B18035,China);the Fundamental of Research Funds for the Central Universities(China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2022JDJQ0050,China);Project of Chengdu Science and Technology Bureau(2020-GH03-00003-HZ)。
Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy.Herein,a kind of tumor cascade-targeted responsive liposome(NLG919@Lip-pep1)is develope...
关键词：Immunotherapy Cascade targeting LIPOSOME MMP-2 responsive Breast cancer ICBs IDO inhibitors Immunosuppressive microenvironment 
YAP regulates the liver size during the fasting-refeeding transition in mice被引量：2
《Acta Pharmaceutica Sinica B》2023年第4期1588-1599,共12页Xuan Li Shicheng Fan Chenghui Cai Yue Gao Xinhui Wang Yifei Zhang Hangfei Liang Huilin Li Jie Yang Min Huang Huichang Bi 
supported by the National Key R&D Program of China(2022YFA1104900);the Natural Science Foundation of China(Grant number:82025034,81973392);the Shenzhen Science and Technology Program(KQTD20190929174023858,China);the 111 project(Grant number:B16047,China);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(Grant number:2017BT01Y093,China);the National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province,Grant number:2017B090903004,China)。
Liver is the central hub regulating energy metabolism during feeding-fasting transition.Evidence suggests that fasting and refeeding induce dynamic changes in liver size,but the underlying mechanisms remain unclear.Ye...
关键词：LIVER FASTING REFEEDING Yes-associated protein Hepatocyte size Hepatocyte proliferation β-Catenin Cyclin D1 
Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy被引量：1
《Acta Pharmaceutica Sinica B》2023年第1期327-343,共17页Zimo Liu Xuefei Zhou Qi Li Youqing Shen Tianhua Zhou Xiangrui Liu 
supported by the National Natural Science Foundation of China(Nos.32101128,21975218,and 51773176);the National Key Research and Development Program of China(2019YFA0802202);the 111 Project(B13026,China)。
Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications.However,administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte sy...
关键词：TRAIL FIBROBLAST NANOPARTICLES Mononuclear phagocyte system Membrane coating CHLOROQUINE Cancer therapy Drug delivery 
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy被引量：22
《Acta Pharmaceutica Sinica B》2022年第12期4327-4347,共21页Yanyan Xu Jingyuan Xiong Xiyang Sun Huile Gao 
This study was supported by National Natural Science Foundation of China(82173762);111 Project(B18035,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2022JDJQ0050,2022YFS0334).
Cancer immunotherapy has significantly flourished and revolutionized the limited conventional tumor therapies,on account of its good safety and long-term memory ability.Discouragingly,low patient response rates and po...
关键词：Cancer immunotherapy Immunosuppressive tumor microenvironment Tumor microenvironment normalization Targeted nanomedicines Drug delivery Environment-responsive nanoparticles Combinational therapy Tumor treatment 
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy
《Acta Pharmaceutica Sinica B》2022年第9期3639-3649,共11页Shaoxing Guan Xi Chen Youhao Chen Guohui Wan Qibiao Su Heng Liang Yunpeng Yang Wenfeng Fang Yan Huang Hongyun Zhao Wei Zhuang Shu Liu Fei Wang Wei Feng Xiaoxu Zhang Min Huang Xueding Wang Li Zhang 
supported by the National Natural Science Foundation of China (Grant Nos. 81973398, 81473283, 81730103, 81573507 and 82020108031);The National Key Research and Development Program (Grant Nos. 2017YFC0909300 and 2016YFC0905000, China);Guangdong Provincial Key Laboratory of Construction Foundation (Grant No. 2017B030314030, China);Science and Technology Program of Guangzhou (201607020031, China);National Engineering and Technology Research Center for New drug Druggability Evaluation (Seed Program of Guangdong Province (No. 2017B090903004, China);the 111 project (Grant: B16047, China);China Postdoctoral Science Foundation (Grant Nos. 2019M66324, 2020M683140 and 2020M683139)
Hepatotoxicity is a common side effect for patients treated with gefitinib,but the related pathogenesis is unclear and lacks effective predictor and management strategies.A multi-omics approach integrating pharmacomet...
关键词：GEFITINIB HEPATOTOXICITY Pharmacometabolomic PHARMACOKINETICS PHARMACOGENOMICS FOXO3 AUTOPHAGY 
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer被引量：6
《Acta Pharmaceutica Sinica B》2022年第8期3354-3366,共13页Wenfeng Jia Rui Liu Yushan Wang Chuan Hu Wenqi Yu Yang Zhou Ling Wang Mengjiao Zhang Huile Gao Xiang Gao 
supported by National Natural Science Foundation of China (82173762);111 Project (B18035,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province (2022JDJQ0050,2022YFS0334);the Open Research Fund of Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China。
Herein, we designed a dual-response shape transformation and charge reversal strategy with chemo-photodynamic therapy to improve the blood circulation time, tumor penetration and retention,which finally enhanced the a...
关键词：Shape transformation Charge reversal Chemo-photodynamic therapy Self-delivery MMP-2 response p H response Carrier-free nanoparticles Breast cancer 
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma
《Acta Pharmaceutica Sinica B》2022年第6期2934-2949,共16页Jiao Xue Yining Zhu Shuting Bai Chunting He Guangsheng Du Yuandong Zhang Yao Zhong Wenfei Chen Hairui Wang Xun Sun 
the financial support of the National Natural Science Foundation of China (Nos.81925036 & 81872814);the Science & Technology Major Project of Sichuan Province (No.2018SZDZX0018,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province (No.2020YFS0570,China);111 project (No.b18035,China);the Fundamental Research Funds for the Central Universities (China)。
Photothermal therapy has been intensively investigated for treating cancer in recent years.However,the long-term therapeutic outcome remains unsatisfying due to the frequently occurred metastasis and recurrence.To add...
关键词：Photothermal therapy IMMUNOTHERAPY Rough surface Polydopamine-coated silica nanoparticles JQ-1 MELANOMA 
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection被引量：8
《Acta Pharmaceutica Sinica B》2022年第4期1987-1999,共13页Xueqin He Xiaorong Wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao 
supported by National Natural Science Foundation of China (81872806, 81961138009);111 Project (B18035, China);the Fundamental of Research Funds for the Central Universities (China);the Open Research Fund of Chengdu University of Traditional Chinese Medicine;the Open Research Fund of Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China
The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of...
关键词：Receptor for advanced glycation end products ROS-responsive Blood‒brain barrier transcytosis Alzheimer’s disease Drug combination Anti-neuroinflammation NEUROPROTECTION Nano drug delivery system 
Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR被引量：1
《Acta Pharmaceutica Sinica B》2022年第3期1339-1350,共12页Fangfang Wang Sora Jin Franklin Mayca Pozo Danmei Tian Xiyang Tang Yi Dai Xinsheng Yao Jinshan Tang Youwei Zhang 
supported by Guangdong Basic and Applied Basic Research Foundation(2021A1515011244,China)to Jinshan Tang;the National 111 Project of China(No.B13038,China)to Xinsheng Yao。
DNA damage response(DDR)is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs.Hence,small molecules that inhibit DDR are expected to enhance the an...
关键词：Chemical screen SHIKONIN DNA damage Response ATM ATR ATRIP Protein degradation Chemo sensitizing 
Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors被引量：6
《Acta Pharmaceutica Sinica B》2022年第3期1416-1431,共16页Yang Zhou Fan Tong Weilong Gu Siqin He Xiaotong Yang Jiamei Li Yue-Dong Gao Huile Gao 
supported by National Natural Science Foundation of China(81961138009,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(No.2020YFS0570,China);111 Project(B18035,China);the Fundamental Research Funds for the Central Universities(China);the Open Research Fund of Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China(China)。
Considering that photodynamic therapy(PDT)-induced oxygen consumption and microvascular damage could exacerbate hypoxia to drive more glycolysis and angiogenesis, a novel approach to potentiate PDT and overcome the re...
关键词：Bilirubin nanoparticles ROS-responsive drug release Charge reversal Photodynamic therapy Hypoxia DICLOFENAC LDHA inhibition HIF-1a inhibition 
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