国家自然科学基金(39925018)

作品数：6被引量：16H指数：3
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相关作者：姚雪彪薛宇符传孩窦震周庆更多>>
相关机构：中国科学技术大学更多>>
相关期刊：《Science Bulletin》《中国科学技术大学学报》《科学通报》《Cell Research》更多>>
相关主题：CENP-EMICROTUBULEKINETOCHOREPHOSPHORYLATION驱动蛋白更多>>
相关领域：生物学更多>>
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细胞动力学研究进展与展望
《中国科学技术大学学报》2008年第8期878-882,共5页姚雪彪 
国家重点基础研究发展(973)计划(2002CB713700);国家自然科学基金(39925018);中国科学院知识创新工程(KSCX2-2-01)资助
细胞是生命活动的最小单元,其功能可塑性及动力学特征是维系生命个体健康及物种繁衍的重要保证.在分子水平,细胞可塑性与动力学特征受遗传学及表观遗传学的调控.随着基因组计划的顺利完成及我们对细胞增殖重要蛋白质作用网络生物化学特...
关键词：基因组 基因组稳定性 细胞动力学 细胞分裂 细胞可塑性 动点 蛋白质作用网络 
Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis被引量：5
《Cell Research》2007年第7期608-618,共11页Guosheng Fu Xia Ding Kai Yuan Felix Aikhionbare Jianhui Yao Xin Cai Kai Jiang Xuebiao Yao 
We thank members of our group for insightful discussion during the course of this study.This work was supported by grants from Chinese Academy of Science(KSCX1-YW-R65,KSCX2-YW-H10);National Basic Research Program of China(2002CB713700);Hi-Tech Research and Development Program of China(2001AA215331);Chinese Minister of Education(20020358051 to XY,PCSIRT0413 to XD);National Natural Science Foundation of China(39925018,30270293 to XY,30500183 to XD,30600222 to JY);National Institutes of Health(USA)(DK56292,CA92080)to XY(a Georgia Cancer Coalition Eminent Scholar);JY was supported by China Postdoctor(2005037560).
Chromosome segregation in mitosis is orchestrated by the interaction of the kinetochore with spindle microtubules. Our recent study shows that NEK2A interacts with MAD 1 at the kinetochore and possibly functions as a ...
关键词：Sgo1 NEK2A PHOSPHORYLATION MICROTUBULE KINETOCHORE 
Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization被引量：3
《Cell Research》2007年第5期449-457,共9页Chuanhai Fu Feng Yan Fang Wu Quan Wu Joseph Whittaker Haiying Hu Renming Hu Xuebiao Yao 
National Natural Science Foundation of China （39925018, 90508002 , 30121001）; Chinese Academy of Science （KSCX 1-R65 and RSCX2-H10）; National Basic Research Program of China （973 project, 2002CB713700）; American Cancer Society （RPG-99-173-01）; a Gcc Breast Cancer Research award and National Institutes of Health grants DK56292 and CA89019 to XY （a GCC Eminent Scholar） and NS36194 （JW）.
During cell division, chromosome segregation is orchestrated by the interaction of spindle microtubules with the centromere. A dramatic remodeling of interpolar microtubules into an organized central spindle between t...
关键词：central spindle MICROTUBULE OLIGOMERIZATION PRC 1 PHOSPHORYLATION 
A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins被引量：1
《Chinese Science Bulletin》2006年第15期1836-1847,共12页XUE Yu LIU Dan FU Chuanhai DOU Zhen ZHOU Qing YAO Xuebiao 
supported by the National Natural Science Foundation of China(Grant Nos.39925018,30121001,30270293&90508002);the Chinese Academy of Sciences(Grant No.KSCX2-2-01);the Chinese 973 Project(Grant No.2002CB713700);the Chinese 863 Project(Grant No.2001AA215331);Chinese Minister of Education(Grant No.20020358051);American Cancer Society(Grant No.RPG-99-173-01).
Kinesin superfamily of microtubule- based motor orchestrates a variety of cellular proc- esses. Recent availability of mammalian genomes has enabled analyses of kinesins on the whole ge- nome. Here we present a novel ...
关键词：驱动蛋白 基因组 CENP-E FKPP 
哺乳动物驱动蛋白的计算基因组学分析与鉴定被引量：4
《科学通报》2006年第14期1654-1665,共12页薛宇 刘丹 符传孩 窦震 周庆 姚雪彪 
国家自然科学基金(批准号:39925018,30270293和30121001);中国科学院知识创新工程(批准号:KSCX2-2-01);国家重点基础研究发展计划(批准号:2002CB713700);国家高技术研究发展规划(批准号:2001AA215331);教育部博士点基金(批准号:20020358051)资助项目.
提供了一种新颖的、基于比较基因组学方法的全长驱动蛋白预测方法(full-lengthkinesinpredictionprogram,FKPP),用于哺乳动物中驱动蛋白质组的鉴定与研究.之前的预测认为,哺乳动物共含94个驱动蛋白,而用FKPP从哺乳动物的基因组中总共鉴...
关键词：驱动蛋白 比较基因组学 CENP-E 全长驱动蛋白预测方法(FKPP) 
Protein kinase TTK interacts and co-localizes with CENP-E to the kinetochore of human cells被引量：3
《Chinese Science Bulletin》2002年第23期2005-2009,共5页Jie Zhang Chuanhai Fu Yong Miao Zhen Dou Xuebiao Yao 
This work was supported in part by the National Natural Science Foundation of China(Grant No.39925018);the Key Project of the Chinese Academy of Sciences(Grant No.KSCX2-2-01).
Spindle checkpoint is an important biochemical signaling cascade during mitosis which monitors the fidelity of chromosome segregation, and is mediated by protein kinases Mpsl and Bubl/BubRl. Our recent studies show th...
关键词：SPINDLE CHECKPOINT TTK protein KINASE CENP-E kinetochore. 
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