《Acta Pharmacologica Sinica》

作品数：5576被引量：27055H指数：43
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《Acta Pharmacologica Sinica》
主办单位：Chinese Pharmacological Society;Shanghai Institute of Materia Medica, Chinese Academy of Sciences
最新期次：2025年2期更多>>
发文主题：APOPTOSISRATSMICEPHARMACOKINETICSINDUCED更多>>
发文领域：医药卫生生物学农业科学化学工程更多>>
发文作者：周宏灏郭兆贵陈季强陈忠郭礼和更多>>
发文机构：中国科学院上海生命科学研究院中国科学院复旦大学浙江大学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Overview and limitations of database in global traditional medicines:A narrative review
《Acta Pharmacologica Sinica》2025年第2期235-263,共29页Xiao-lan Li Jian-qing Zhang Xuan-jing Shen Yu Zhang De-an Guo 
supported by the Qi-Huang Chief Scientist Project of the National Administration of Traditional Chinese Medicine(2020);the Sanming Project of Medicine in Shenzhen(SZZYSM202106004);Key Program of National Natural Science Foundation of China(82130111);National Natural Science Foundation of China(82003940);Key-Area Research and Development Program of Guangdong Province(2020B1111110007).
The study of traditional medicine has garnered significant interest,resulting in various research areas including chemical composition analysis,pharmacological research,clinical application,and quality control.The abu...
关键词：traditional medicine DATABASES PHYTOCHEMICALS pharmacological activity quality control 
Cyclic GMP-AMP synthase recognizes the physical features of DNA
《Acta Pharmacologica Sinica》2025年第2期264-270,共7页Ling Dong Yue-ru Hou Na Xu Xiao-qian Gao Zhen Sun Qing-kai Yang Li-na Wang 
supported by grants from the National Natural Science Foundation of China(82173072).
Cyclic GMP-AMP synthase(cGAS)is a major cytosolic DNA sensor that plays a significant role in innate immunity.Upon binding to double stranded DNA(dsDNA),cGAS utilizes GTP and ATP to synthesize the second messenger cyc...
关键词：innate immune response cytosolic DNA sensor cyclic GMP-AMP synthase STING DNA physical features 
The correlation between mitochondria-associated endoplasmic reticulum membranes(MAMs)and Ca^(2+)transport in the pathogenesis of diseases
《Acta Pharmacologica Sinica》2025年第2期271-291,共21页Wen-bin Zhao Rui Sheng 
supported by grants from the National Natural Science Foundation of China(No.82173811,81973315);Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD)and Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases.
Mitochondria and the endoplasmic reticulum(ER)are vital organelles that influence various cellular physiological and pathological processes.Recent evidence shows that about 5%–20%of the mitochondrial outer membrane i...
关键词：mitochondria-associated ER membranes Ca^(2+)homeostasis cardiovascular diseases neurodegenerative diseases CANCER 
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rαcross-talk and drives neuroinflammation in mouse ischemic stroke
《Acta Pharmacologica Sinica》2025年第2期292-307,共16页Shuai Wang Yi Guo Rui-qi Cao Yong-ming Zhu Shi-gang Qiao Hua-ping Du Yuan Liu Yuan Xu Xian-yong Zhou Lei Sun Qi-xia Lu Ingmar Schoen Hui-ling Zhang 
supported by grants from the National Natural Science Foundation of China(81473211,81874311,82073841,82373863);the Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Project of Medical Research of Jiangsu Commission of Health(Z2023014);the Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Suzhou Science and Technology Project(SYSD2020044,SKY2022082).
Astrocyte-derived IL-3 activates the corresponding receptor IL-3Rαin microglia.This cross-talk between astrocytes and microglia ameliorates the pathology of Alzheimer’s disease in mice.In this study we investigated ...
关键词：ischemic stroke IL-3/IL-3Rαcross talk VEGFD/VEGFR3 astrocytes MICROGLIA NEUROINFLAMMATION 
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 andα-synuclein autophagic degradation obstacle
《Acta Pharmacologica Sinica》2025年第2期308-325,共18页Sha-sha Wang Ye Peng Ping-long Fan Jun-rui Ye Wen-yu Ma Qing-lin Wu Hong-yun Wang Ya-juan Tian Wen-bin He Xu Yan Zhao Zhang Shi-feng Chu Nai-hong Chen 
supported by the National Key R&D Program of China(2022YFC3500300);the National Natural Science Foundation of China(82130109,81973499);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-020).
Emerging evidence shows that psychological stress promotes the progression of Parkinson’s disease(PD)and the onset of dyskinesia in non-PD individuals,highlighting a potential avenue for therapeutic intervention.We p...
关键词：Parkinson's disease(PD) psychological stress RG1 RTP801 a-Synuclein AUTOPHAGY 
Artemisinin inhibits neuronal ferroptosis in Alzheimer’s disease models by targeting KEAP1
《Acta Pharmacologica Sinica》2025年第2期326-337,共12页Peng-xi Deng Marta Silva Na Yang Qing Wang Xin Meng Ke-qiang Ye Hong-chang Gao Wen-hua Zheng 
supported by National Natural Science Foundation of China(32070969 and 22274115);the Science and Technology Development Fund,Macao SAR(0104/2022/A2 and 0038/2020/AMJ);Guangdong,Hong Kong and Macao Joint Key Laboratory for New Drug Screening(EF2023-00054-FHS,GDSTC);the Guangdong Provincial Funding Committee for Basic and Applied Fundamental Research(2022-Natural Science Foundation,EF019/FHS-ZWH/2022,GDSTC);University of Macao(MYRG-CRG2024-00019-FHS,MYRG-GRG2023-00118-FHS-UMDF and MYRG2022-00154-FHS).
Ferroptosis,a form of cell death characterized by lipid peroxidation,is involved in neurodegenerative diseases such as Alzheimer´s disease(AD).Recent studies have shown that a first-line antimalarial drug artemisinin...
关键词：Alzheimer’s disease ARTEMISININ ferroptosis KEAP1 Nrf2 HIPPOCAMPUS 
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice
《Acta Pharmacologica Sinica》2025年第2期338-352,共15页Jun-qiang Zhao Bing-yan Feng Zhen-li Ye Xiao-yin Ma Jing-zhi Du Jun-mei Li Wan-liu Wu Jing-jing Gao Song-ji Li Shi-yong Peng Ji-sen Huai Li-hao Ge Cheng-biao Lu 
supported by the National Natural Science Foundation of China(NSFC:81771517,81271422);the Key Project of the 14th Five-Year Plan of Educational Science in Henan Province(2021JKZD09);the Key Scientific and Technological Project in Henan Province(212102310654);the Henan Province Medical Science and Technology Key Project Jointly Constructed by Province and Ministry(SBGJ202102189);the Key R&D and Promotion Projects in Henan Province(222102310615);Natural Science Foundation of Henan Province(242300421307);the Tai-hang Scholar Research Fund from Xinxiang Medical University;and the Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,the Second Affiliated Hospital of Xinxiang Medical University(XTkf11).
Palmitoyl-protein thioesterase 1(PPT1)is a lysosomal depalmitoylation enzyme that mediates protein posttranslational modifications.Loss-of-function mutation of PPT1 causes a failure of the lysosomal degradation of pal...
关键词：infantile neuronal ceroid lipofuscinosis palmitoyl-protein thioesterase 1 cognitive functions γoscillations DOPAMINE dopamine D4 receptor 
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
《Acta Pharmacologica Sinica》2025年第2期353-365,共13页Ya-nan Gao Kai-jun Pan Yong-mei Zhang Ying-bei Qi Wen-gang Chen Ting Zhou Hai-chao Zong Hao-ran Guo Jin-wen Zhao Xing-chen Liu Zi-tong Cao Ze Chen Tao Yin Yi Zang Jia Li 
founded by National Natural Science Foundation of China grant 82001572;National Natural Science Foundation of China grant 81971265;National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”grant 2018ZX09711002-007-002;Shanghai Commission of Science and Technology grant 2021000003;Shanghai Science and Technology Development Funds(Shanghai Commission of Science and Technology)grant 19JC1416300.
Depressive disorders are a global mental health challenge that is closely linked to inflammation,especially in the post-COVID-19 era.The JAK-STAT pathway,which is primarily associated with inflammatory responses,is no...
关键词：tofacitinib depression JAK-STAT pathway MICROGLIOSIS synaptic defects 
Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARαin acute promyelocytic leukemia
《Acta Pharmacologica Sinica》2025年第2期462-473,共12页Xue-jing Shao Wei Wang Ai-xiao Xu Xiao-tian Qi Min-yi Cai Wen-xin Du Ji Cao Qiao-jun He Mei-dan Ying Bo Yang 
supported by grants from the National Key R&D Program of China(2021YFA1300604);the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province(LR24H310001);the Fundamental Research Funds for the Central Universities.
The oncogenic fusion protein promyelocytic leukemia/retinoic acid receptor alpha(PML/RARα)is critical for acute promyelocytic leukemia(APL).PML/RARαinitiates APL by blocking the differentiation and increasing the se...
关键词：acute promyelocytic leukemia PML/RARa drug resistance PALMITOYLATION ZDHHC3 
G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner
《Acta Pharmacologica Sinica》2025年第2期474-488,共15页Fa-liang Xing Bo-rui Li Ying-jin Fang Chen Liang Jiang Liu Wei Wang Jin Xu Xian-jun Yu Yi Qin Bo Zhang 
supported by the National Natural Science Foundation of China(82173178,82173281,U21A20374,and 82072698);Shanghai Municipal Science and Technology Major Project(21JC1401500);Scientific Innovation Project of Shanghai Education Committee(2019-01-07-00-07-E00057);Natural Science Foundation of Shanghai Municipal Science and Technology Committee(21ZR1415200);Natural Science Foundation of Shanghai(23ZR1479300).
Pancreatic ductal adenocarcinoma(PDAC)is distinguished by its aggressive malignancy,limited treatment avenues and a tendency towards chemotherapy resistance,underscoring the critical need for advanced research to unco...
关键词：pancreatic ductal adenocarcinoma gemcitabine resistance G3BP2 PDIA3-DKC1-hENT stress granules 
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