《Acta Pharmacologica Sinica》

作品数：5625被引量：27191H指数：43
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《Acta Pharmacologica Sinica》
主办单位：Chinese Pharmacological Society;Shanghai Institute of Materia Medica, Chinese Academy of Sciences
最新期次：2025年4期更多>>
发文主题：APOPTOSISRATSMICEPHARMACOKINETICSINDUCED更多>>
发文领域：医药卫生生物学农业科学化学工程更多>>
发文作者：周宏灏郭兆贵陈季强陈忠郭礼和更多>>
发文机构：中国科学院上海生命科学研究院中国科学院复旦大学浙江大学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling
《Acta Pharmacologica Sinica》2025年第4期795-804,共10页Zheng-Jie Chia Hirushi Kumarapperuma Ruizhi Zhang Peter J.Little Danielle Kamato 
supported by a Future Leader Fellowship(106605)from the National Heart Foundation of Australia;HK and ZJC are supported by the Research Training Scholarship from the University of Queensland.
The Smad transcription factors are well known for their role at the core of transforming growth factor-β(TGF-β)signalling.However,recent evidence shows that the Smad transcription factors play a vital role downstrea...
关键词：transforming growth factor-beta receptor SMAD transactivation dependent GPCR signalling Akt phospho-Smad 
Multifaceted roles of UFMylation in health and disease
《Acta Pharmacologica Sinica》2025年第4期805-815,共11页Ru-na Wang Lin Li Jun Zhou Jie Ran 
supported by grants from the National Natural Science Foundation of China(32241014 and 32170687).
Ubiquitin fold modifier 1(UFM1)is a newly identified post-translational modifier that is involved in the UFMylation process.Similar to ubiquitination,UFMylation enables the conjugation of UFM1 to specific target prote...
关键词：UFMylation UFM1 post-translational modification DISEASE therapeutic target 
Targeting chaperone-mediated autophagy in neurodegenerative diseases:mechanisms and therapeutic potential
《Acta Pharmacologica Sinica》2025年第4期816-828,共13页Jin Wu Wan Xu Ying Su Guang-hui Wang Jing-jing Ma 
supported by the National Natural Science Foundation of China(grants 32400789 and 32070970);the Natural Science Foundation of Jiangsu Province(grants BK20240436);the Suzhou Science and Technology Development Plan(SZM2023006 and SKYD2023179);the Gusu Key Health Talent Program of Suzhou(GSWS2022122).
The pathological hallmarks of various neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease prominently feature the accumulation of misfolded proteins and neuroinflammation.Chaperone-media...
关键词：neurodegenerative diseases chaperone-mediated autophagy neuronal proteostasis NEUROINFLAMMATION CMA modulators 
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease
《Acta Pharmacologica Sinica》2025年第4期829-835,共7页Wei Zhou Hong-Yuan Chu 
funded in part by Aligning Science Across Parkinson’s(ASAP-020572);NIH grants(R01NS121371 and R21NS135545);Department of Defense Congressionally Directed Medical Research Programs(W81XWH-21-1-0943);Parkinson’s Foundation(PF-IMP-1045313).
The locus coeruleus norepinephrine(LC-NE)system plays an important role in regulating brain function,and its neuronal loss has been well-documented in Parkinson’s disease(PD).The LC-NE neurodegeneration is believed t...
关键词：locus coeruleus NOREPINEPHRINE DOPAMINE parkinson’s disease motor cortex cognition 
Poria cocos:traditional uses,triterpenoid components and their renoprotective pharmacology
《Acta Pharmacologica Sinica》2025年第4期836-851,共16页Zhi-yuan Guo Xin Wu Shui-juan Zhang Jian-hua Yang Hua Miao Ying-yong Zhao 
supported by the Shaanxi Key Science and Technology Plan Project(No.2023-ZDLSF-26);National Natural Science Foundation of China(Nos.82274079,82274192,82074002 and 81872985).
Poria cocos and its surface layer of Poria cocos(Schw.)Wolf(Polyporaceae),are used in traditional Chinese medicine for its diuretic and renoprotective effects.Phytochemical studies have shown that lanostane and 3,4-se...
关键词：Poria cocos renoprotective effect acute kidney injury chronic kidney disease renal fibrosis TGF-Β1/SMAD 
A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia
《Acta Pharmacologica Sinica》2025年第4期852-866,共15页Wei Tang Rong Cheng Meng-yue Gao Min-jin Hu Lu Zhang Qiang Wang Xin-yu Li Wei Yan Xiao-ying Wang Hai-mei Yang Jian Cheng Zi-chun Hua 
supported by the National Natural Science Foundation of China(82071469,32271033);the Priority Academic Program Development of the Jiangsu Higher Education Institutions(PAPD);Jiangsu Department of Science and Technology(BK20230164,BK20230165,BE2023695,BK20231136 and BK20243001);Changzhou Municipal Department of Science and Technology(2022169,CJ2023001,CJ20220019,and CJ20235009);the Suzhou Clinical Research Center of Neurological Disease(Szzx201503)and the Jiangsu Key Laboratory Grant(BM2013003).
Despite the vital role of astrocytes in preserving blood-brain barrier(BBB)integrity,their therapeutic potential as targets in ischemic stroke-induced barrier disruption remains underexplored.We previously reported ex...
关键词：cerebral ischemia blood-brain barrier ASTROCYTES PHOSPHATIDYLSERINE Annexin A5 
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses
《Acta Pharmacologica Sinica》2025年第4期867-879,共13页Jing Cui Xiao-ran Wang Jie Yu Bo-rui Zhang Ya-fei Shi Kwok-Fai So Li Zhang Ji-an Wei 
funded by STI2030-Major Projects(2022ZD0207600)to LZ;National Natural Science Foundation of China(U22A20301 to KFS);Guangdong Major Project of Basic and Applied Basic Research(2023B0303000004)to KFS and LZ;Guangdong Basic and Applied Basic Research Foundation(2023B1515040015)to LZ;Guangdong Special Support Program for Young Talented Researchers(2023TQ07A102)to LZ;Guangzhou Basic and Applied Basic Research Foundation(SL2023A03J00544,SL2024A04J00149)to LZ;The Fundamental Research Funds for the Central Universities(21624207)to LZ;the Key Research and Development Plan of Ningxia(2022BEG01004)to KFS.
Astrocytes are known to modulate synaptogenesis or neuronal activities,thus participating in mental functions.It has been shown that astrocytes are involved in the antidepressant mechanism.In this study we investigate...
关键词：stress resilience astrocyte-neuron interplay NEUROPEPTIDE PACAP PAC1 SNARE pathway 
Activation of glutamine synthetase(GS)as a new strategy for the treatment of major depressive disorder and other GS-related diseases
《Acta Pharmacologica Sinica》2025年第4期880-891,共12页Jae Soon Kang Hwajin Kim Ji Hyeong Baek Miyoung Song Hyeongchan Park Wonjune Jeong Hye Jin Chung Dae Young Yoo Dong Kun Lee Sang Won Park Hyun Joon Kim 
supported by the National Research Foundation(NRF)(Grant numbers NRF-2021R1A5A802949012 and 2022R1A2C100529611);the Commercializations Promotion Agency for R&D Outcomes(COMPA)(Grant number 1711173796)funded by the Ministry of Science and ICT(MSIT)of the Korean government.
Glutamine synthetase(GS)plays a crucial role in the homeostasis of the glutamate–glutamine cycle in the brain.Hypoactive GS causes depressive behaviors.Under chronic stress,GS has no change in expression,but its acti...
关键词：depression glutamine synthetase tyrosine nitration tyrosine-containing dipeptide EPILEPSY HYPERAMMONEMIA 
The effects of diazepam on sleep depend on the photoperiod
《Acta Pharmacologica Sinica》2025年第4期892-903,共12页Maria Panagiotou Johanna H.Meijer Tom Deboer 
supported by a grant from the Dutch Technology Foundation(STW);the Velux Stiftung(Zurich,Switzerland number 1289)to TD.
Daylength(i.e.,photoperiod)provides essential information for seasonal adaptations of organisms.Earlier studies have demonstrated that photoperiod influences sleep in several species.Notably,photoperiod can change the...
关键词：SLEEP PHOTOPERIOD EEG slow-wave-activity diazepam GABA 
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons
《Acta Pharmacologica Sinica》2025年第4期904-921,共18页Ou-Yang Zhanmu Yang Yang Bin Feng Hong-yang Wang Hao Li Hui-juan Zhou Wen-qiang Ge Ke-xing Wan Sui-xi Wang Kai-ling Zhang Hong Zhang Lei Pei Hui-lin Pan Qing Tian Man Li 
supported by grants from the National Youth Natural Science Foundation(82205275,82305002);the Chinese Postdoctoral Foundation(0106510145,0106510062).
Itch causes a strong urge to scratch and induces negative emotions,such as aversion and anxiety.Antihistamine medications are key in the clinical management of pruritus,but their therapeutic efficacy in controlling mo...
关键词：cannabinoid receptor MPFC PRURITUS 
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