supported by the National Natural Science Foundation of China(U21A20393);the 1.3.5 project for disciplines of excellence and the Brain Science project of West China Hospital(ZYGD23032);the postdoctoral research fund of West China Hospital(2024HXBH095);the National Key R&D Program(2021YFC2401204,2022YFC2503805);the NIHR University College London Hospitals Biomedical Research Centre;the UK Department of Health sponsors;support from the Marvin Weil Epilepsy Research Fund;the UK Epilepsy Society;the National Institute of Health Research;the Academy of Medical Sciences.
Background Mesial temporal lobe epilepsy(mTLE)is the most common form of focal epilepsy,often associated with hippocampal sclerosis.Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and ...
supported by National Key R&D Program of China(2021YFF1200700).
Background Stereotactic electroencephalography(SEEG)has emerged as a widely utilized diagnostic approach in epilepsy surgery,demonstrating broad clinical applications and a favorable safety profile.SEEG,when combined ...
supported by grants from the Beijing E-Town Cooperation&Development Foundation(YCXJ-JZ-2022–007).
Background Preferential activation of Acid-sensing ion channel 1a(ASIC1a)by acidosis promotes seizure termination.Studies have found that CO_(2)can reduce neuronal excitability and inhibit seizure activity.Dravet synd...
Zain Aslam(112-36551-2BM1-037);Bibi Zubaida(212-52789-2BM2-080);supported by the Higher Education Commission of Pakistan under Indigenous Ph.D.Fellowships Program.
Background Autosomal recessively inherited progressive myoclonic epilepsy of Lafora,which is also known as Lafora disease,is a fatal neurodegenerative disorder.It affects individuals in late childhood or early adolesc...
approved by the Ethics Committee of the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)(2024-RE-325)。
Background Hemorrhagic stroke has a high incidence,often leaving patients with significant complications such as limb mobility disorders after treatment.Traditional treatment methods for stroke patients mainly include...
Background Dissociative seizures(DS),also known as psychogenic non-epileptic seizures(PNES),often mimic epileptic seizures(ES),leading to misdiagnosis,unnecessary anti-seizure medications(ASMs)/suboptimal use of ASMs,...
supported by grants from the National Natural Science Foundation of China(82373859);the China Postdoctoral Science Foundation(2023M743145).
Ablation of seizure foci represents a crucial therapeutic approach for epilepsy.Traditionally,the seizure foci are predominantly located in the anterior hippocampus and amygdala.However,recent research by Ivan Soltesz...
supported by the National Institute for Health and Care Research(NIHR)Newcastle Biomedical Research Centre(BRC)based at the Newcastle upon Tyne Hospitals NHS Foundation Trust,Newcastle University;the Cumbria,Northumberland,and Tyne and Wear(CNTW)NHS Foundation Trust.
Epilepsy is one of the most common neurological disorders,affecting more than 50 million people worldwide.Management is particularly complex in individuals with intellectual disabilities,who are at a much higher risk ...
funded by the National Natural Science Foundation of China(XFY 82271492).
Epilepsy,characterized by recurrent seizures,is influenced by biological rhythms,such as circadian,seasonal,and menstrual cycles.These rhythms affect the frequency,severity,and timing of seizures,although the precise ...
supported by the Youth project of key Laboratory of Ministry of Education(3000971).
Febrile infection-related epilepsy syndrome(FIRES)is a rare epilepsy syndrome with unclear pathogenesis,characterized by fever-induced,super-refractory status epilepticus and high mortality.Studies have shown that ket...