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Multimodal comparison of plasma proteins associated with blood-brain barrier impairment in Alzheimer’s disease: 《Aging Communications》2024年第1期1-9,共9页Elisa Giunti Roberto Collu Joel Reisman Jong Soo Lee Noureddine Melikechi Weiming Xia; University of Massachusetts Lowell-Bedford VA Healthcare System Pilot Award(NM,WX,EG),I01 BX004730 and I01 BX003527 Merit Awards from the Biomedical Laboratory Research and Development of the Veterans Affairs Office of Research and Development(WX);RF1AG063913 from the NIH(WX).; Background:Vascular impairment is one of the major contributors to dementia.We aimed to identify blood biomarkers suggestive of potential impairment of the blood-brain barrier(BBB)in subjects with Alzheimer’s disease...; 关键词：Alzheimer’s disease blood-brain barrier peripheral biomarkers matrix metalloproteinases cerebral amyloid angiopathy

Exploring the interplay of lncRNA,senescence and urinary tumors:opportunities and challenges: 《Aging Communications》2023年第4期1-2,共2页De-Chao Feng Rui-Cheng Wu Zhou-Ting Tuo Jie Wang Xing Ye Deng-Xiong Li; Introduction About 72%of human genome is transcribed to non-coding RNAs,which have captivated researchers a lot for shedding light on their pivotal roles in regulating the initiation and progression of various disease...; 关键词：URINARY METABOLISM IRREVERSIBLE

Proper beverages may reduce the risk of Alzheimer’s disease: 《Aging Communications》2023年第4期3-6,共4页Lian-Yi Hu Shi-Jin Cheng Jia-Rong Shi Yu-Hui Wang Xin-Ju Li; Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by a progressive decline in cognitive ability. Around 50 million people worldwide are reportedly affected, with annual los...; 关键词：METABOLISM protective integrating

Unveiling shared genetic pathways in cardiovascular diseases:towards personalized therapies and holistic treatment approaches: 《Aging Communications》2023年第4期7-8,共2页Jiang-Shan Tan Zhi-Qiang Liu Yi-Meng Wang Song Hu Yuan-Rui Deng Ling-Tao Chong Yan-Min Yang Lu Hua; Cardiovascular diseases(CVDs),encompassing diverse pathologies such as atherosclerosis,hypertension,cardiomyopathy,arrhythmia,and valvular diseases,represent a significant public health challenge,severely undermining ...; 关键词：diseases MORTALITY TREATMENT

Activation of Nrf2 alleviates Parkinson’s disease-like pathology:a new strategy targeting the C/EBPβ/α-Syn pathway: 《Aging Communications》2023年第4期9-10,共2页Ze-Fang Lin Wei Yao; This study was financially supported by the National Natural Science Foundation of China(No.82271563 and No.82204786);The Natural Science Foundation of Guangdong Province of China(No.2022A1515012512);The Academic Promotion Program of Shandong First Medical University.; Parkinson’s disease(PD)is a prevalent neurological disorder around the globe,currently affecting over 6 million people globally[1].It is estimated that by 2040,this number may double to more than 12 million[2].Aging ...; 关键词：IMPAIRED SHAKING globally

Study on the clinical effect and safety of Kangfuxin liquid combined with microneedling in the treatment of facial skin photoaging: 《Aging Communications》2023年第3期1-5,共5页Yi Chen Hu Ren Qiong Guo Ting-Ting Zhong Rui-Lan Xi Dan Xiao Yan Wang; Background and Objectives:Microneedling has been introduced as a new technique to address the growing concern of facial skin photoaging.Kangfuxin liquid has been found to promote the process of skin wound repair,inclu...; 关键词：Kangfuxin liquid microneedling facial skin photoaging VISIA

Targeting gut microbiota:an emerging therapeutic target for Parkinson’s disease: 《Aging Communications》2023年第3期6-7,共2页Chen-Chen Yan Yi-Ran Sun; This study was financially supported by Henan Youth Science Foundation of Henan Province(No.232300421310);Postdoctoral Foundation of China(No.2022M711080);The National Natural Science Foundation of China(No.82274612);Program for Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTIT044);Innovative Research Team(in Science and Technology)in University of Henan Province(21IRTSTHN026);Henan Province Traditional Chinese Medicine Scientific Research Special Project(No.2022ZYZD21);Joint Research Fund of Science and Technology R&D Plan of Henan Province(NO.222301420068).; Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suf...; 关键词：DEGENERATION INFLAMMATION DOPAMINE

Empowering women to combat osteoporosis:unveiling the causes,consequences,and control strategies: 《Aging Communications》2023年第3期8-17,共10页Seyi Samson Enitan Babatunde Ishola Gabriel Adejumo Esther Ngozi Adejumo Temitope Oyewole Olusanya Eguagie Osareniro Osakue Oluwakemi Anike Ladipo Comfort Bosede Enitan; Osteoporosis is a common bone disease in women worldwide, leading to decreased bone density and an accelerated risk of fractures. The causes of osteoporosis in women include age (senile osteoporosis), menopause-associ...; 关键词：WOMEN AGING OSTEOPOROSIS CAUSES consequences control strategies

Protocol to study the effects of AMPK-mTOR/PINK-Parkin dual signaling pathways on the formation of coronary heart disease showing blood stasis symptom pattern based on traditional Chinese medicine theory of“heart governing blood and vessels”: 《Aging Communications》2023年第3期18-22,共5页An-Ni Chen Man-Li Zhou Yun-Feng Yu Kang-Yan Tang Lin-Juan Yang Mo-Fei Shi Wei-Xiong Jian; This work was supported by the National Natural Science Foundation of China(No.81973753 to Jian WX);Hunan Postgraduate Scientific Research Innovation Project(CX 20220781);Hunan University Students’Innovation and Entrepreneurship Training Program(S202210541116).; In this study,we aim to combine gene transfection techniques with the modeling methods previously employed by the research group to deeply investigate the corresponding theories of traditional Chinese medicine regard...; 关键词：coronary heart disease with blood stasis syndrome heart governing blood and vessels AMPK-mTOR/PINK-Parkin energy metabolism platelet autophagy study protocol

Role of ferroptosis in Parkinson’s disease and intervention mechanism of acupuncture and moxibustion: 《Aging Communications》2023年第3期23-27,共5页Xiao-Qian Hao Shu-Ping Zhu Qing-Lian Li Da Gao Xiao-Ling Wang Qi-Zhang Wang Mei-Ling Zhu; This work was supported by,the Shenzhen Science and Technology Program(JCYJ20210324123614040);the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A151510450);the Medical Scientific Research Foundation of Guangdong Province(No.B2023087);the Sanming Project of Medicine in Shenzhen(Grant No.SZZYSM202106009);the Bao’an TCM Development Foundation(Grant No.2022KJCX-ZJZL-7);National Administration of Traditional Chinese Medicine(GZY-FJS-2022-59).; Parkinson’s disease(PD)is the second neurodegenerative disease in the world.The pathological characteristics of PD are degeneration,loss and death of dopaminergic neurons in the substantia nigra of the midbrain.At pr...; 关键词：ferroptosis Parkinson’s disease ACUPUNCTURE MOXIBUSTION intervention mechanism

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