《Mechanobiology in Medicine》

作品数：61被引量：21H指数：2
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《Mechanobiology in Medicine》
主办单位：上海交通大学
最新期次：2024年4期更多>>
发文主题：MECHANOBIOLOGYMECHANOTRANSDUCTIONSTIFFNESSECMMEC更多>>
发文领域：医药卫生理学一般工业技术自动化与计算机技术更多>>
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In vivo analysis of hybrid hydrogels containing dual growth factor combinations,and skeletal stem cells under mechanical stimulation for bone repair
《Mechanobiology in Medicine》2024年第4期97-109,共13页David Gothard Michael Rotherham Emma L.Smith Janos M.Kanczler James Henstock Julia A.Wells Carol A.Roberts Omar Qutachi Heather Peto Hassan Rashidi Luis Rojo Lisa J.White Molly M.Stevens Alicia J.El Haj Felicity R.J.ose Richard O.C.Oreffo 
supported by the BBSRC(sLOLA grant BB/G010579/1);an EU ERC Advanced Grant DYNACEUTICS(grant no.789119).
Bone tissue engineering requires a combination of materials,cells,growth factors and mechanical cues to recapitulate bone formation.In this study we evaluated hybrid hydrogels for minimally invasive bone formation by ...
关键词：Growth factors Controlled release Bone ECM Bone formation MECHANOTRANSDUCTION Skeletal stem cell 
miRNA in mechanobiology:The exploration needs to continue
《Mechanobiology in Medicine》2024年第4期1-3,共3页Kai Huang Yingxin Qi 
supported by grants from the National Natural Science Foundation of China(grant numbers 12032003,12302409).
The 2024 Nobel Prize in Physiology or Medicine has once again sparked considerable interest in microRNA(miRNA).Recent advances have unveiled that miRNAs play critical roles in mediating the effects of mechanical stimu...
关键词：MECHANOTRANSDUCTION microRNA(miRNAs) Mechanical stress 
Harnessing mechanobiology to enhance cell therapy
《Mechanobiology in Medicine》2024年第4期4-6,共3页Peixiang Ma An Qin Tobias Winkler Jie Zhao 
supported by the National Science Foundation of China(82130073 J.Z.);National Key R&D Program of China(2021YFA1100802 P.M.);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System,Biomaterials and Regenerative Medicine Institute Cooperative,Research Project,Shanghai Jiaotong University School of Medicine(2022LHA01 J.Z.).
Recent developments in cell therapy have revolutionized medical treatment.While various methods of stimulation have been explored,the role of mechanical force has often been overlooked.Although mechanical loading is n...
关键词：Cell therapy MECHANOBIOLOGY Mechanogenetics Synthetic biology 
Effects of gravity,microgravity or microgravity simulation on early mouse embryogenesis:A review of the first two space embryo studies
《Mechanobiology in Medicine》2024年第4期7-14,共8页Douglas M.Ruden Daniel A.Rappolee 
supported by an NIH ECHO grant to DMR,UG3 OD023285.
Many simulated micro-gravity(micro-G)experiments on earth suggest that micro-G conditions are not compatible with early mammalian embryo development.Recently,the first two“space embryo”studies have been published sh...
关键词：MICROGRAVITY CLINOSTAT International space station(ISS) EMBRYOGENESIS 
Viscoelasticity of ECM and cells-origin,measurement and correlation
《Mechanobiology in Medicine》2024年第4期15-31,共17页Zhiqiang Liu Si Da Ling Kaini Liang Yihan Chen Yudi Niu Lei Sun Junyang Li Yanan Du 
supported by the National Natural Science Foundation of China(grant no.82061148010)。
The extracellular matrix(ECM)and cells are crucial components of natural tissue microenvironments,and they both demonstrate dynamic mechanical properties,particularly viscoelastic behaviors,when exposed to external st...
关键词：Extracellular matrix Cell VISCOELASTICITY ORIGIN MEASUREMENT CORRELATION 
YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis
《Mechanobiology in Medicine》2024年第4期32-44,共13页Rakibul Islam Zhongkui Hong 
supported,in part,by the National Science Foundation Grant 2304667(to Z.H.);the National Institutes of Health Grant 7 R15 HL147214-02(to Z.H.).
Cardiovascular diseases(CVDs)persistently rank as a leading cause of premature death and illness worldwide.The Hippo signaling pathway,known for its highly conserved nature and integral role in regulating organ size,t...
关键词：HIPPO YAP/TAZ Cardiovascular diseases MECHANOTRANSDUCTION Signaling 
Application of biomechanics in tumor epigenetic research
《Mechanobiology in Medicine》2024年第4期45-58,共14页Qi Wang Xiaohong Yin Yunyi Ding Hong Zhao Yichen Luo 
supported by Science and Technology Program of Zhejiang Province(Grant No.2023C03071).
The field of cancer research is increasingly recognizing the complex interplay between biomechanics and tumor epigenetics.Biomechanics plays a significant role in the occurrence,development,and metastasis of cancer an...
关键词：TUMOR BIOMECHANICS EPIGENETIC Tumor microenvironment 
Low intensity mechanical signals promote proliferation in a cell-specific manner:Tailoring a non-drug strategy to enhance biomanufacturing yields
《Mechanobiology in Medicine》2024年第4期59-68,共10页M.Ete Chan Christopher Ashdown Lia Strait Sishir Pasumarthy Abdullah Hassan Steven Crimarco Chanpreet Singh Vihitaben S.Patel Gabriel Pagnotti Omor Khan Gunes Uzer Clinton T.Rubin 
supported by the Long Island Bioscience Hub funded through the NIH-Research Evaluation and Commercialization Hub(U-HL127522);the Research Foundation Technology Accelerator Fund,the Center for Biotechnology(NYSTAR)as well as grants from NIH(AG059923,P20GM109095)and NSF(1929188&2025505).
Biomanufacturing relies on living cells to produce biotechnology-based therapeutics,tissue engineering constructs,vaccines,and a vast range of agricultural and industrial products.With the escalating demand for these ...
关键词：Biomanufacturing Cell proliferation Mechanical stimulation BIOMECHANICS Adherent cells Suspension cells Stem cells Vibration 
Strain and hyaluronic acid interact to regulate ovarian cancer cell proliferation,migration,and drug resistance
《Mechanobiology in Medicine》2024年第4期69-82,共14页Maranda Kramer Allyson Criswell Kamari Marzette Emerson Cutcliffe Mary Kathryn Sewell-Loftin 
funding sources:R00-CA230202(M.K.S.L.);IMPACT Award(O'Neal Comprehensive Cancer Center,M.K.S.L.);the Fine Family Philanthropic Grant(M.K.S.L),UAB Blazer Fellowship(M.K.)and T32-EB023872(M.K.).
The ovarian tumor microenvironment plays a critical yet is poorly understood role in the regulation of cancer cell behaviors including proliferation,migration,and response to chemotherapy treatments.Ovarian cancer is ...
关键词：Ovarian cancer MECHANOBIOLOGY Tumor microenvironment Hyaluronic acid CD44 CHEMORESISTANCE 
Low-magnitude high-frequency vibration reduces prostate cancer growth and extravasation in vitro
《Mechanobiology in Medicine》2024年第4期83-96,共14页Amel Sassi Kimberly Seaman Xin Song Chun-Yu Lin Yu Sun Lidan You 
supported by the Natural Science and Engineering Research Council(NSERC,Grant No:06465-14).
Prostate cancer(PCa)continues to rank among the most common malignancies in Europe and North America with significant mortality rates despite advancements in detection and treatment.Physical activity is often recommen...
关键词：Low-magnitude high-frequency vibration Mechanical loading Vibration Prostate cancer Bone metastasis OSTEOCYTE Microfluidic SPHEROID 
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