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Exploring the molecular mechanism of Solanum nigrum L in breast cancer treatment through network pharmacology and molecular docking validation: 《Pharmacology Discovery》2024年第3期1-16,共16页Mei Zheng Ju-Min Xie; supported by Local special projects in major health of Hubei Provincial Science and Technology Department(2022BCE054);Key scientific research projects of Hubei polytechnic University(23xjz08A);Hubei polytechnic University Huangshi Daye Lake high-tech Zone University Science Park joint open fund project(23xjz04AK).; In 2020,breast cancer emerged as the leading type of cancer worldwide,surpassing lung cancer in the number of new cases.The high cost and frequent failure of current treatments due to drug resistance and other challen...; 关键词：ANTI-CANCER molecular docking network pharmacology Solanum Nigrum L

Pharmacokinetics of Gelsemium elegans in female rats: 《Pharmacology Discovery》2024年第3期17-21,共5页Xiao-Tong Zhang Jun-Jie Cao Meng-Ting Zuo Zhao-Ying Liu; supported by the National Natural Science Foundation of China(No.31972737).; Background:Gelsemium elegans Benth(G.elegans)is a poisonous perennial evergreen vine plant that has been applied in livestock production and veterinary clinical practice.Early studies found that the toxicity of G.eleg...; 关键词：Gelsemium elegans ALKALOIDS PHARMACOKINETICS female rats

Research progress on the anti-tumor effect of Codonopsis pilosula: 《Pharmacology Discovery》2024年第3期22-29,共8页Xing-Lei Yin Ren-Jun Gu Xuan Han; support of the National Natural Science Foundation of China(Grant No.82204696);the Natural Science Foundation project of Nanjing University of Chinese Medicine(Grant No.XPT82204696).; Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medici...; 关键词：Codonopsis pilosula ANTI-TUMOR molecular mechanism Codonopsis polysaccharides ISOIMPERATORIN SAPONINS

Advances in cytokine-mediated mechanisms for cardiac regeneration and repair post-myocardial infarction:a comprehensive review: 《Pharmacology Discovery》2024年第3期30-35,共6页Zi-Heng Zhang Yang Yang; supported by the Henan Medical Science and Technology Joint Building Program(No.LHGJ20230283);the Medical Science and Technology Research Project of Henan Province(No.SBGJ202103079).; Cardiovascular disease(CVD)has become the leading cause of death globally,imposing significant health and economic burdens.Among these,myocardial infarction(MI)is a predominant cause of mortality.Several animal studie...; 关键词：CYTOKINES myocardial infarction experimental animal model promotion of cytokine release

Bibliometric analysis of 100 most-cited papers on Icariin: 《Pharmacology Discovery》2024年第3期36-47,共12页Lin Mao Yi-Feng Shen Kun Zhu Jun-Long Zhu Xiao-Peng Huang De-Gui Chang Yao-Dong You Dong-Dong Yang; supported by the Natural Science Foundation of Sichuan Province(2023NSFSC1799);the Science and Technology Development Fund of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(21ZS05,23YY07).; Icariin is the most prevalent component of the medicinal herb Herba Epimedii.Icariin exhibits many medicinal properties,including anti-cancer impact and osteoprotective and neuroprotective effects.The goal of this stu...; 关键词：ICARIIN Herba Epimedii VOSviewer BIBLIOMETRICS

Biguanides and lactic acidosis:unraveling the complex relationship: 《Pharmacology Discovery》2024年第3期48-51,共4页Shreyash Narade; Biguanides,such as metformin,have long been established as frontline medications for the management of type 2 diabetes due to their glucose-lowering effects and favorable safety profiles.However,concerns regarding the...; 关键词：BIGUANIDES METFORMIN lactic acidosis type 2 diabetes PHARMACOVIGILANCE

Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis: 《Pharmacology Discovery》2024年第2期1-9,共9页Ansari Vikhar Danish Ahmad Misba Ruhi Syed Ayaz Ali Qazi Yasar Mohd.Mukhtar Khan Subur W Khan Mohammed Imran Anees; Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families Asteraceae.Conversely,Myristic acid is characterized by its str...; 关键词：myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking

Study on the mechanism of SND in the treatment of anxiety disorders based on network pharmacology, molecular docking and experiment validation: 《Pharmacology Discovery》2024年第2期10-23,共14页Fei-Yan Wang Ping Yuan Mei-Ling Zheng Xiao-Di Guo Long Li Jin Wang Shan Miao Ya-Jun Shi Shan-Bo Ma Xiao-Peng Shi; financially supported by the Shaanxi Province Key Project for Social Development(No.2022SF-205).; Background:Sini decoction(SND)is a classic traditional Chinese medicine(TCM)formulation that can be used to treat anxiety-related disorders,but the active substance and underlying molecular mechanism of its anxiolytic...; 关键词：SND anxiety disorders network pharmacology molecular docking pharmacological mechanisms

Efficiency and safety of Tripterygium Wilfordii Hook F for IgA nephropathy: an update systematic review and meta-analysis: 《Pharmacology Discovery》2024年第2期24-31,共8页Zi-Yi He Hui-Chuan Tian Yan Zhao Rui-Yu Mou Hong-Wei Yuan; supported by the Foundation.The authors are grateful to Dr.Jia Yingjie for his help with the preparation of the ideas in this paper.; Background:Immunoglobulin A Nephropathy(IgAN)currently stands as the most prevalent primary chronic glomerular disease worldwide.The latest guidelines recommend the application of renin-angiotensin system inhibitors(R...; 关键词：TRIPTERYGIUM IgA nephropathy systematic review META-ANALYSIS

Comparative study of anti-inflammatory effects of different processed products through the COX-2/PGE2 signaling pathway: based on network pharmacology and molecular docking: 《Pharmacology Discovery》2024年第2期32-45,共14页Ping Chen Yun-Yun Quan An-Qi Zeng Ying Dai Jin Zeng; supported by Sichuan Province Science and Technology Support Program(NO.2020JDJQ0063,NO.2020YFS0566 and NO.2021JDKY0037,A-2021N-Z-5).; Background:Radix Aconiti Lateralis Preparata(Fu-zi)is a traditional Chinese medicinal herb,which has been widely used in the clinic and has potent anti-inflammatory activities.we aimed to explore the mechanisms of ext...; 关键词：Radix Aconiti Lateralis Preparata(Fu-zi) rheumatoid arthritis ANTI-INFLAMMATORY network pharmacology COX-2/PGE2 signaling pathway

《Pharmacology Discovery》