supported by the Key Research Projects of Universities of Henan Province,No.21A320064 (to XS);the National Key Research and Development Program of China,No.2021YFA1201504 (to LZ);the Strategic Priority Research Program of the Chinese Academy of Science,No.XDB36000000 (to CW);the National Natural Science Foundation of China,Nos.31971295,12374406 (both to LZ)。
Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a s...
partially supported by Bright Focus Glaucoma grant No. G2022015S (to MF)
Retinal dysfunction is the most common cause of vision loss in several retinal disorders.It has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,al...
Huntington’s disease is a genetic disease caused by expanded CAG repeats on exon 1 of the huntingtin gene located on chromosome 4.Compelling evidence implicates impaired mitochondrial energetics,altered mitochondrial...
Ionizing radiation caused by medical treatments,nuclear events or even space flights can irreversibly damage structure and function of brain cells.That can result in serious brain damage,with memory and behavior disor...
Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons,which are caused by a group of retinal diseases affecting various age groups...
supported by the Instituto de Salud Carlos III (project PI13/01124 and Ocular Pathology National Net RETICS-Oftared RD16/0008);the Fondo Europeo de Desarrollo Regional (FEDER) funds:“Una manera de hacer Europa”;the Government of Aragon (Group B08_17R and Predoctoral Grant L.Perdices,C060/2014)。
Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor loss.RP has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),t...
supported by the National Science Fund of Bulgaria(Young scientists project contract KП-06-М29/4;to NA,MA,NHA,and DA).
Neuroprotective drugs and selective monoamine oxidase inhibitors can slow down the progression and improve symptoms of Parkinson’s disease(PD).Since there is an implication of oxidative stress in the pathophysiologic...
Ischemic stroke continues to be a leading cause of mortality and morbidity in the world. Despite recent advances in the field of stroke medicine, thrombolysis with recombinant tissue plasminogen activator remains as t...
Parkinson's disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor symptoms.Over the years,several factors have been discovered to play a role in the pathogenesis of this ...
supported by the National Natural Science Foundation of China,No.31770385(to SQJ)
Orientin is a flavonoid monomer.In recent years,its importance as a source of pharmacological active substance is growing rapidly due to its properties such as anti-myocardial ischemia,anti-apoptosis,anti-radiation,an...