云南高校图书馆联盟文献共享服务平台- COSTIMULATION

COSTIMULATION: 作品数：22被引量：75H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关机构：南京市第二医院更多>>; 相关期刊：《Cellular & Molecular Immunology》《World Journal of Gastroenterology》《World Journal of Immunology》《Hepatobiliary & Pancreatic Diseases International》更多>>; 相关基金：国家自然科学基金广东省自然科学基金更多>>

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors: 《Cellular & Molecular Immunology》2024年第4期374-392,共19页Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao; CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse models.We recently identified cDC1s with a transcriptom...; 关键词：CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

CD28 costimulation promotes an antitumor CD8^(+) T cell response in myeloid antigen-presenting cell niches: 《Cellular & Molecular Immunology》2022年第2期147-149,共3页Jacques A.Nunès Daniel Olive; The team“Immunity and Cancer”was labeled by the Fondation pour la Recherche Médicale“Equipe FRM DEQ20180339209”.DO is Senior Scholar of the Institut Universitaire de France.; Ectopic lymphoid structures found within the tumor stroma,such as tertiary lymphoid structures(TLSs),are predictive markers of immune checkpoint blockade(ICB)in solid tumors.In a recent study in Cancer Cell,Duraiswamy...; 关键词：stimulation MYELOID al.

Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses: 《Cellular & Molecular Immunology》2021年第8期1956-1968,共13页Seon-Hee Kim Rohit Singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi; This study was supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(2018R1A6A3A01011692[SHK]from MOE and 2019R1C1C1008999[CH]from MSIT);the National Cancer Center of Korea(NCC-1810102/191050/1911261[BKC]and NCC-2010190[CH]).; The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy.However,the adverse side effects associated with agonist antibodies have hindered their clinical deve...; 关键词：4-1BB COSTIMULATION GRANULOMA CD8 lymphocyte MACROPHAGE

Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin被引量：4: 《Cellular & Molecular Immunology》2020年第4期380-394,共15页Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag; supported by a grant from the German Research Foundation(SFB CRC156,project B04 and INST 114089/31-1 FUGG to Y.S.).; The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing che...; 关键词：KERATINOCYTES inflammatory skin diseases psoriasis human T cells COSTIMULATION CD2 LFA-1 nonprofessional antigenpresenting cells Th1 cells Th17 cells

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus被引量：2: 《Signal Transduction and Targeted Therapy》2020年第1期1746-1755,共10页Yujun Pei Kun Wen Zheng Xiang Chunyu Huang Xiwei Wang Xiaofeng Mu Liyan Wen Yinping Liu Wenwei Tu; supported in part by the General Research Fund,Research Grants Council of Hong Kong(17115015,17121214,17126317,17122519);Theme-based Research Scheme from the Research Grants Council of the Hong Kong SAR,China(Project No.T11-705/14N);Chinese National Natural Science Foundation of China(31570898);Natural Science Foundation of Guangdong Province,China(2016A030313112).; Influenza epidemics and pandemics are constant threats to global public health.Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection,the effic...; 关键词：CD137 INFLUENZA DRUGS

B7-DC (PD-L2) costimulation of CD4^(+) T-helper 1 response via RGMb被引量：6: 《Cellular & Molecular Immunology》2018年第10期888-897,共10页Xinxin Nie Wenni Chen Ying Zhu Baozhu Huang Weiwei Yu Zhanshuai Wu Sizheng Guo Yiping Zhu Liqun Luo Shengdian Wang Lieping Chen; supported by grants from Guangdong Province Innovative Research Program Project(No.2011Y035);863 Project grants to Sun Yat-sen University and the United Technologies Corporation endowed chair from Yale University.; The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo.In addition to interacting with...; 关键词：ASTHMA B7-DC K113S RGMb TH1/TH2

Immunological Intolerance and Tolerance by Antigenic Co-Stimulation: 《Open Journal of Immunology》2017年第4期59-84,共26页Alexandre Paulo Machado Gabriel de Paula Albuquerque Letícia Souza Santana Olga Fischman Gompertz; The plasticity and dynamism in the immune responses to both self and environmental stimulation promote the maintenance and adaptation of a system that tends to harmoniously survive and evolve. Fluctuating antigenic fo...; 关键词：IMMUNOLOGICAL TOLERANCE and INTOLERANCE ANTIGEN COSTIMULATION (AgCS)

Responses to LPS boost effector CD8 T-cell accumulation ）utside of signals 1 and 2: 《Cellular & Molecular Immunology》2017年第3期254-264,共11页Wenhai Liu Antoine Menoret Anthony T. Vella; Immunization with adjuvant plus antigen induces durable T-cell immunity and is a mainstay of vaccines. Here, the consequence of separating antigen stimulation of T cells from the adjuvant response was studied in a re-...; 关键词：ADJUVANT COSTIMULATION CYTOKINE T cell

Costimulatory blockade:A novel approach to the treatment of glomerular disease?被引量：1: 《World Journal of Methodology》2015年第2期20-25,共6页Pasquale Esposito Teresa Rampino Antonio Dal Canton; Costimulatory pathways(Cluster of differentiation 28,tumor necrosis factor-related,adhesion and T Cell Ig-and mucin-domain molecules) regulating the interactions between receptors on the T cells andtheir ligands expre...; 关键词：COSTIMULATION GLOMERULONEPHRITIS Cluster of differentiation 80 Cytotoxic T-lymphocyte-associated antigen-4 Lupus nephritis ABATACEPT PROTEINURIA PODOCYTES

CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells被引量：3: 《World Journal of Immunology》2014年第2期63-77,共15页Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens; Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte an...; 关键词：Regulatory T cells Tolerance CYTOTOXIC T lymphocyte antigen-4Ig Anti-CD40L COSTIMULATION

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