MECHANOSENSITIVE

作品数：19被引量：23H指数：3
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相关期刊：《Neuroscience Bulletin》《Mechanobiology in Medicine》《医用生物力学》《Smart Molecules》更多>>
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Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease
《Genes & Diseases》2025年第3期93-107,共15页Shiying Sun Wen Wang 
supported by grants from the Natural Science Foundation of Hebei Province(China)(No.H2020206226);Hebei Province Science and Technology Support Program(China)(No.18277756D);the Science and Technology Research Project of Hebei Higher Education Institutions(China)(No.ZD2022010);High-level talent funding project of Hebei(China)(No.20231141)to W.W.
Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals throughmechanotransduction. As a member of the G p...
关键词：Activation mechanism aGPCR Health and disease MECHANOTRANSDUCTION Signaling pathway 
Periostin^(+) myeloid cells improved long bone regeneration in a mechanosensitive manner
《Bone Research》2024年第4期895-911,共17页Ziyan Wang Minmin Lin Yonghao Pan Yang Liu Chengyu Yang Jianqun Wu Yan Wang Bingtong Yan Jingjing Zhou Rouxi Chen Chao Liu 
supported by grants from Shenzhen Science and Technology Innovation Commission (KQTD20200820113012029,JCYJ20190809114209434)。
Myeloid cells are pivotal in the inflammatory and remodeling phases of fracture repair.Here,we investigate the effect of periostin expressed by myeloid cells on bone regeneration in a monocortical tibial defect(MTD)mo...
关键词：MYELOID STIMULATION MEC 
Highly tough,crack-resistant and self-healable piezo-ionic skin enabled by dynamic hard domains with mechanosensitive ionic channel
《Smart Molecules》2024年第3期118-127,共10页XueBin Wang Tong Liu FuYao Sun Jingyi Zhang BoWen Yao JianHua Xu JiaJun Fu 
National Key Research and Development Program of China(Grant No.2022YFB3808800);the National Nature Science Foundation of China(Grant No.52272084,Grant No.52202101,Grant No.52203002,Grant No.52072177);the National Science Foundation of Jiangsu Province(Grant No.BK20220430);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(Grant No.22KJB430007);the Fundamental Research Funds for the Central Universities(Grant No.2023102003,Grant No.30924010202).
Robust and reliable piezo-ionic materials that are both crack resistant and selfhealable like biological skin hold great promise for applications inflexible electronics and intelligent systems with prolonged service l...
关键词：crack resistance piezo-ionic dynamics SELF-HEALING 
Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis被引量：1
《Genes & Diseases》2024年第3期206-219,共14页Shuyu Li Zichen Xu Yi Wang Lizhao Chen Xiangxiu Wang Yanghao Zhou Daoxi Lei Guangchao Zang Guixue Wang 
supported in part by the National Natural Science Foundation of China(No.31971242,12032007);the Chongqing Science and Technology Bureau(China)(No.cstc2021jsyj-yzysbA0057);the Joint Medical Research Project of Chongqing Science and Technology Bureau and Chongqing Health Commission(China)(No.2018ZDXM032).
Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and...
关键词：ATHEROSCLEROSIS Blood flow Endothelial cell Mechanosensitive gene Therapeutic target 
Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery被引量：1
《Mechanobiology in Medicine》2024年第1期31-47,共17页Hongyuan Zhu Run Miao Jin Wang Min Lin 
supported by the National Natural Science Foundation of China(12202345,12372316,12022206);China Postdoctoral Science Foundation(2022M722534);Natural Science Basic Research Plan in Shaanxi Province of China(2022KWZ-17);the Shaanxi Province Youth Talent Support Program;the Young Talent Support Plan of Xi'an Jiaotong University.
Mechanical models offer a quantitative framework for understanding scientific problems,predicting novel phenomena,and guiding experimental designs.Over the past few decades,the emerging field of cellular mechanobiolog...
关键词：Cellular mechanobiology Mechanical models Mechanosensitive receptors CYTOSKELETON NUCLEUS 
Mechanosensitive Piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation
《Neural Regeneration Research》2023年第11期2385-2386,共2页Mo Zhang Philippa Malko Lin-Hua Jiang 
A PhD Studentship from University of Leeds (to PM);Start-Up Fund from Xinxiang Medical University (to LHJ)。
Microglial cells are the key immunocompetent cells in the central nervous system (CNS) and play a crucial role in CNS health and disease (Paolicelli et al.,2022).Under the homeostatic conditions,microglial cells assum...
关键词：INFLAMMATION DISEASES function 
Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrinβ_(2)to manipulate inflammatory responses
《Nano Research》2023年第7期9715-9729,共15页Yuanlong Guo Yong Ao Chen Ye Ruidi Xia Jiaomei Mi Zhengjie Shan Mengru Shi Lv Xie Zetao Chen 
This work was financially supported by the National Natural Science Foundation of China(No.82061167);the National Key Research and Development Program of China(No.2022YFA1104400);the International Team for Implantology(ITI)Research Grant(No.1536_2020);Fundamental Research Funds of Sun Yat-sen University(No.22ykqb06);Science and Technology Program of Guangzhou(No.SL2022B03J00507);Guangdong Financial Fund for High-Caliber Hospital Construction,and National Undergraduate Training Program for Innovation and Entrepreneurship(No.202210772).
Finely tuning mechanosensitive membrane proteins holds great potential in precisely controlling inflammatory responses.In addition to macroscopic force,mechanosensitive membrane proteins are reported to be sensitive t...
关键词：nanotopographic structures micro-nano forces mechanosensitive membrane proteins protein conformational changes inflammatory responses 
Mechanobiology research in China被引量：1
《Mechanobiology in Medicine》2023年第1期17-27,共11页Zong-Lai Jiang 
supported by the National Natural Science Foundation of China,Nos.11972232,31670958,11542006,11232010,10732070,3047032,and 10132020.
Mechanobiology is an interdisciplinary discipline combining biology,engineering,chemistry,physics,and medicine.Mechanobiology research comprehensively discusses,the role of mechanical factors in various life processes...
关键词：MECHANOTRANSDUCTION Cardiovascular disease OSTEOARTHROPATHY Tumor mechano-microenvironment Mechanosensitive molecule 
Non-canonical role of the ATR pathway in axon regeneration as a mechanosensitive brake
《Neural Regeneration Research》2022年第11期2423-2424,共2页Feng Li Yuanquan Song 
the National Institutes of Health Grant,1R01NS107392(to YS).
DNA damage has been linked to neuropathology.Diverse DNA damage response(DDR)pathways help preserve DNA integrity in the nervous system during both the developmental and mature stages.Mutations of factors in various s...
关键词：damage ATR DDR 
The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention被引量：10
《Bone Research》2022年第2期338-353,共16页Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li 
supported by the National Natural Science Foundation of China Project (Nos. 31630038, 81822026,91740114, 81830061, and 31900849)
Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that ...
关键词：STIMULATION MEC IMPAIRED 
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