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作品数：92被引量：261H指数：8
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相关机构：南京工业大学南京大学福建中医药大学中国人民解放军第一军医大学更多>>
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Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood–brain barrier
《Neural Regeneration Research》2026年第1期377-391,共15页Yinying Wang Rongsha Chen Guolin Shi Xinwei Huang Ke Li Ruohua Wang Xia Cao Zhongshan Yang Ninghui Zhao Jinyuan Yan 
supported by the National Natural Science Foundation of China,Nos. 32260196 (to JY), 81860646 (to ZY) and 31860274 (to JY);a grant from Yunnan Department of Science and Technology,Nos. 202101AT070251 (to JY), 202201AS070084 (to ZY), 202301AY070001-239 (to JY), 202101AZ070001-012, and 2019FI016 (to ZY)。
Studies have shown that chitosan protects against neurodegenerative diseases. However, the precise mechanism remains poorly understood. In this study, we administered chitosan intragastrically to an MPTP-induced mouse...
关键词：ACETATE adenosine 5′-monophosphate-activated protein kinase blood–brain barrier CHITOSAN dopamine neurons INFLAMMATION intestinal barrier Parkinson's disease peroxisome proliferator-activated receptor delta short-chain fatty acids 
Bioinspired Surface Engineering with Dual Covalent Receptors Incorporated via Precise Post-Imprinting Modification to Enhance the Specific Identification of Adenosine 5′-Monophosphate
《Engineering》2025年第2期143-154,共12页Pan Wang Tao Cheng Zhuangxin Wei Lu Liu Yue Wang Xiaohua Tian Jianming Pan 
supported by the National Natural Science Foundation of China(22078132,22108103,and U22A20413);the Open Funding Project of the National Key Labora-tory of Biochemical Engineering(2021KF-02);China Postdoctoral Science Foundation(2021M691301);Jiangsu Key Research and Development Program(BE2022356);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(CPSF)(GZ20230989);Jiangsu Agricultural Independent Innovation Fund Project(CX(21)3079).
Expanding the specific surface area of substrates and carrying out precise surface engineering of imprinted nanocavities are crucial methods for enhancing the identification efficiency of molecularly imprinted polymer...
关键词：Precise surface engineering Dual covalent receptor Precise post-imprinting modification Specific identification of adenosine 5-monophosphate 
Fanlian Huazhuo Formula:A promising herbal preparation for metabolic liver disease被引量：1
《World Journal of Gastroenterology》2024年第46期4964-4968,共5页Bhupesh Singla 
Supported by the National Institutes of Health Grants,No.K99HL146954 and No.R00HL146954;the College of Pharmacy Seed Research Grant Program of the University of Tennessee Health Science Center.
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)has increased significantly in recent decades and is projected to increase further due to the rising obesity rates.MASLD patients are at...
关键词：Metabolic dysfunction-associated steatotic liver disease Fanlian Huazhuo Formula De novo lipogenesis Cell death Adenosine-5’-monophosphate-activated protein kinase alpha Acetyl-CoA carboxylase 
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective
《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia 
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
关键词：STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin 
Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues
《Chinese Journal of Integrative Medicine》2024年第2期125-134,共10页Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-Ki Park Hyo Won Jung 
Supported by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI),the Ministry of Health&Welfare,Republic of Korea (No. HF20C0121);Shanxi Key Laboratory of Tradition Herbal Medicines Processing (No. 20210901);the Innovation Team of Shanxi University of Chinese Medicine (No. 2022TD1014)
Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes mice...
关键词：high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis 
Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway被引量：1
《Neural Regeneration Research》2023年第9期2067-2074,共8页Tong-Tong Lin Chun-Yi Jiang Lei Sheng Li Wan Wen Fan Jin-Can Li Xiao-Di Sun Chen-Jie Xu Liang Hu Xue-Feng Wu Yuan Han Wen-Tao Liu Yin-Bing Pan 
supported by the National Natural Science Foundation of China;Nos.81971047 (to WTL) and 82073910 (to XFW);the Natural Science Foundation of Jiangsu Province,No.BK20191253 (to XFW);Key R&D Program (Social Development) Project of Jiangsu Province,No.BE2019 732 (to WTL);Jiangsu Province Hospital (the First Affiliated Hospital of Nanjing Medical University) Clinical Capacity Enhancement Project,No.JSPH-511B2018-8 (to YBP)。
Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory p...
关键词：adenosine 5’-monophosphate-activated protein kinase heme oxygenase-1 high mobility group box-1 INTERLEUKIN-1Β MICROGLIA morphine tolerance NEUROINFLAMMATION neuron nuclear factor-κB p65 Toll-like receptor 4 
Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway被引量：3
《Chinese Journal of Integrative Medicine》2023年第9期801-808,共8页LIU Hong CHEN Wei-dong HU Yang-lin YANG Wen-qiang HU Tao-tao WANG Huan-lan ZHANG Yan-min 
Supported by the Chinese Medicine Research Project of Hubei Provincial Health Commission(No.ZY2019Q024);Scientific Research Project of Wuhan Municipal Health Commission(No.WX20B11);Scientific Research Project of Wuhan Municipal Health Commission(No.WZ20C01)。
Objective To investigate the effect of emodin on high glucose(HG)-induced podocyte apoptosis and whether the potential anti-apoptotic mechanism of emodin is related to induction of adenosine-monophosphate-activated pr...
关键词：EMODIN diabetic nephropathy AUTOPHAGY podocyte apoptosis adenosine-monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathways 
Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology被引量：4
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第8期682-698,共17页Yang CHEN Qian LI Sisi REN Ting CHEN Bingtao ZHAI Jiangxue CHENG Xiaoyan SHI Liang SONG Yu FAN Dongyan GUO 
supported by the General Project of Shaanxi Science and Technology Plan(No.2021JM-472);the Key Laboratory Project of Education Department of Shaanxi Province(Nos.21JS014 and 21JS007);the Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019YL14);the Postgraduate Student’s Innovation Project of Shaanxi University of Chinese Medicine(No.2021-09),China。
Objective:To determine the potential molecular mechanisms underlying the therapeutic effect of curcumin on hepatocellular carcinoma(HCC)by network pharmacology and experimental in vitro validation.Methods:The predicti...
关键词：CURCUMIN Network pharmacology p53 Adenosine 5’-monophosphate(AMP)-activated protein kinase(AMPK) Apoptosis AUTOPHAGY 
Liraglutide suppresses the proliferation of endometrial cancer cells through the adenosine 5'-monophosphate(AMP)-activated protein kinase signaling pathway被引量：2
《Chinese Medical Journal》2021年第5期576-578,共3页Xin-Xin Zhu Zong-Hao Feng Lin-Zhi Liu Yan Zhang 
This work was supported by a grant from the National Natural Science Foundation of China(No.81272870).
This study investigated the effect of liraglutide(an analog of human glucagon-like peptide-1[GLP-1])on the proliferation of Ishikawa(IK)and human endometrial carcinoma(HEC)-IB endometrial cancer(EC)cell lines,identifi...
关键词：ENDOMETRIAL cancer PROGESTERONE 
The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3',5'-monophosphate(Epac)for central nervous system trauma被引量：3
《Neural Regeneration Research》2021年第3期460-469,共10页Alba Guijarro-Belmar Dominik Mateusz Domanski Xuenong Bo Derryck Shewan Wenlong Huang 
supported by Scottish Rugby Union funding to WH and DS;the NRB PhD scholarship from the International Spinal Rsesarch Trust to AGB;a Hot-Start Scholarship from the University of aberdeen to DD。
Millions of people worldwide are affected by traumatic spinal cord injury,which usually results in permanent sensorimotor disability.Damage to the spinal cord leads to a series of detrimental events including ischaemi...
关键词：ASTROCYTES axonal regeneration cAMP central nervous system regeneration Epac glial scar microglia NEUROINFLAMMATION neurons spinal cord spinal cord injury traumatic spinal cord injury 
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