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Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期2840-2842,共3页Jörg Fahrer 
supported by the German Research Foundation(INST 248/331-1 FUGG,FA1034/3-3,project number 258652740,FA 1034/6-1,project number 496762016,FA1034/8-1,project number 527664508);Kooperation Phytopharmaka GbR,Bonn,Germany(TU-KL#2);the European Partnership for the Assessment of Risks from Chemicals(PARC)under the Horizon Europe Research and Innovation Programme,Grant Agreement No.101057014.
A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,canc...
关键词：CHROMOSOMAL LINKING REPLICATION 
Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization
《Signal Transduction and Targeted Therapy》2023年第11期5146-5148,共3页Junyi Wang Guoping Li Min Wu 
the National Natural Science Foundation of China(81970026,82000029,82200079);the National Key Clinical Specialist Construction Project(2023031L);the Natural Science Foundation of Sichuan(2022NSFSC1324,23NSFSC1736);the Chengdu High-level Key Clinical Specialty Construction Project(ZX20201202020);Wenzhou Institute of University of Chinese Academyof Sciences。
A recent publication in Cell by Rangan et al.highlights the remarkable ability of squids to dynamically regulate the function of microtubule motor proteins through RNA recoding in response to ocean temperature fluctua...
关键词：PLASTICITY characterization 
Segregating memories: targeting microenvironment of neuronal ensembles被引量：1
《Signal Transduction and Targeted Therapy》2022年第11期3995-3997,共3页Ying Liu Miao Xu Wei-Guang Li 
Ministry of Science and Technology China Brain Initiative Project(2021ZD0202802);National Natural Science Foundation of China(32071023);Program of Shanghai Academic Research Leader(22XD1420700);innovative research team of high-level local universities in Shanghai.
A recent study by Shen et al.reported that a delayed augmentation in the neuronal expression of C–C chemokine receptor type 5(CCR5)—a well-known immune molecule in the peripheral inflammatory microenvironment—after...
关键词：LINKING ENSEMBLE DATING 
Linking B cell metabolism to immune regulation:the neurotransmitter GABA被引量：1
《Signal Transduction and Targeted Therapy》2022年第9期3143-3144,共2页Yang Shi 
Y.Shi receives funding support from the European Research Council(ERC Starting Grant,101040996);the German Research Foundation(DFG,SH 1223/1-1);the Excellence Strategy of the Federal Government and the Lander(Project(DE-82)EXS-SF-OPSF580).
In a recent study published in Nature,1Zhang et al.reported that activated B cells produced and released the principal inhibitory neurotransmitter y-aminobutyric acid(GABA).The GABA secretion was demonstrated to inhib...
关键词：IMMUNITY METABOLISM al. 
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq被引量：4
《Signal Transduction and Targeted Therapy》2021年第6期1833-1844,共12页Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen 
supported by National Natural Science Foundation of China(31970881)and(82041046)to Y.Q.C.;Shenzhen Science and Technology Program under Grant(JCYJ20190807154603596 and JCYJ20200109142438111);the National Key Research and Development Project(2020YFC0841700)to M.W.;the National Natural Science Foundation of China(32041002)to D.Y.G.;the Special Fund for COVID-19 Epidemic Prevention&Control of Zhuhai City of China granted to S.D.C.
B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we ...
关键词：PATIENTS SPECIFICITY LINKING 
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties被引量：4
《Signal Transduction and Targeted Therapy》2021年第4期1171-1198,共28页Kieran Joyce Georgina Targa Fabra Yagmur Bozkurt Abhay Pandit 
This publication has emanated from research supported in part by a Grant from Science Foundation Ireland and is co-funded under the European Regional Development Fund under Grant number 13/RC/2073_P2;The authors would like to acknowledge the College of Medicine Nursing and Health Sciences Scholarship,NUI Galway;This project has also received funding from the European Union’s Horizon 2020 research and innovation program iPSpine under the grant agreement No.825925 and under the Marie Sktodowska-Curie grant agreement No 813263.
Biomaterials have had an increasingly important role in recent decades,in biomedical device design and the development of tissue engineering solutions for cell delivery,drug delivery,device integration,tissue replacem...
关键词：BIOMATERIALS LINKING POTENTIAL 
Methionine metabolism in chronic liver diseases:an update on molecular mechanism and therapeutic implication
《Signal Transduction and Targeted Therapy》2021年第1期17-25,共9页Zhanghao Li Feixia Wang Baoyu Liang Ying Su Sumin Sun Siwei Xia Jiangjuan Shao Zili Zhang Min Hong Feng Zhang Shizhong Zheng 
This work was financially supported by the National Natural Science Foundation of China(81870423 and 82073914);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(19KJA310005);the Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica(JKLPSE202005,JKLPSE201815,and JKLPSE 201804);the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX20_0536 and KYCX20_1493).
As one of the bicyclic metabolic pathways of one-carbon metabolism,methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway.In addition to being a precursor for glutathione synthesis...
关键词：synthesis. LINKING DONOR 
H3.3S31 phosphorylation:linking transcription elongation to stimulation responses被引量：1
《Signal Transduction and Targeted Therapy》2020年第1期986-987,共2页Hong Wen Xiaobing Shi 
supported in part by grants from NCI(CA204020);Leukaemia&Lymphoma Society Career Development Program(1339-17)to X.S.
Phosphorylation of histone proteins is involved in multiple cellular functions such as mitosis,DNA damage response,and transcriptional regulation.For example,phosphorylation of H3.3 Ser31(H3.3S31ph)is known as a mitot...
关键词：PHOSPHORYLATION STIMULATION RESIDUE 
Action mechanisms and research methods of tRNA-derived small RNAs被引量：18
《Signal Transduction and Targeted Therapy》2020年第1期1505-1513,共9页Yaoyao Xie Lipeng Yao Xiuchong Yu Yao Ruan Zhe Li Junming Guo 
supported by grants from the National Natural Science Foundation of China(no.81974316);the Scientific Innovation Team Project of Ningbo(no.2017C110019);Zhejiang Key Laboratory of Pathophysiology(no.202001);the K.C.Wong Magna Fund in Ningbo University.
tRNA-derived small RNAs(tsRNAs),including tRNA-derived fragments(tRFs)and tRNA halves(tiRNAs),are small regulatory RNAs processed from mature tRNAs or precursor tRNAs.tRFs and tiRNAs play biological roles through a va...
关键词：MECHANISMS LINKING INHIBITING 
Methionine metabolism in chronic liver diseases:an update on molecular mechanism and therapeutic implication被引量：3
《Signal Transduction and Targeted Therapy》2020年第1期172-180,共9页Zhanghao Li Feixia Wang Baoyu Liang Ying Su Sumin Sun Siwei Xia Jiangjuan Shao Zili Zhang Min Hong Feng Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(81870423 and 82073914);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(19KJA310005);the Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica(JKLPSE202005,JKLPSE201815,and JKLPSE 201804);the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX20_0536 and KYCX20_1493).
As one of the bicyclic metabolic pathways of one-carbon metabolism,methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway.In addition to being a precursor for glutathione synthesis...
关键词：synthesis LINKING DONOR 
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