云南高校图书馆联盟文献共享服务平台- GYPENOSIDE

GYPENOSIDE: 作品数：11被引量：45H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：朴香兰刘慧敏杨静曾鸣陈道金更多>>; 相关机构：中央民族大学大连医科大学北京海淀妇幼保健院深圳大学更多>>; 相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》《食品安全质量检测学报》更多>>; 相关基金：国家自然科学基金中国博士后科学基金更多>>

Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis被引量：1: 《Acta Pharmaceutica Sinica B》2024年第3期1380-1399,共20页Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang; supported by National Natural Science Foundation of China(Nos.82073780 and 82273868,China);Shanghai Municipal Natural Science Foundation(No.19ZR1406200,China)。; Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obst...; 关键词：Autophagy-lysosome pathway Alzheimer’s disease PROTEOSTASIS Neuroinflammation Multi-target therapy RAPAMYCIN Gypenoside XVII Cascade dual-targeting

Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cαand inhibiting deposition of extracellular matrix被引量：2: 《Chinese Journal of Natural Medicines》2023年第8期599-609,共11页LIU Yue YANG Yating WANG Hanghang LI Han LV Qi WANG Xiachang WU Dalei HU Lihong ZHANG Yinan; supported by the National Key R&D Program(No.2018YFC1707900);the National Natural Science Foundation of China(No.22177052);Jiangsu Provincial Science and Technology Development Project of Chinese Medicine(No.ZD202002);Jiangsu postgraduate scientific research innovation program(No.KYCX21_1721).; Gypenosides,structurally analogous to ginsenosides and derived from a sustainable source,are recognized as the principal active compounds found in Gynostemma pentaphyllum,a Chinese medicinal plant used in the treatmen...; 关键词：Dammarane-type triterpenoid GYPENOSIDE Liver fibrosis Extracellular matrix

Gypenoside, the Main Active Compound of Gynostemma pentaphyllum , Mitigates the Diabetic Nephropathy through Down-regulating mTOR: 《Clinical Complementary Medicine and Pharmacology》2023年第2期74-85,共12页Chao Chen Danqing Fu Yuqian Wu Chen Huang Ping Huang; Background:Diabetic nephropathy(DN),as a complication of diabetes,is featured with hypertension,hyper-glycemia,proteinuria and edema.Gypenoside(GP),the main active compound of Gynostemma pentaphyllum,is proved to be e...; 关键词：Network pharmacology GYPENOSIDE Diabetic nephropathy Molecular targets Mechanism of action Signaling pathways

Diploid chromosome-level reference genome and population genomic analyses provide insights into Gypenoside biosynthesis and demographic evolution of Gynostemma pentaphyllum (Cucurbitaceae): 《Horticulture Research》2023年第1期82-95,共14页Xiao Zhang Yuhe Zhao Yixuan Kou Xiaodan Chen Jia Yang Hao Zhang Zhe Zhao Yuemei Zhao Guifang Zhao Zhonghu Li; This study was supported by the National Natural Science Foundation of China(Nos.32000256,31900273,31770229,and 31270364);a Project funded by the China Postdoctoral Science Foundation(No.2020M673627XB);the Key Pro-gram of Research and Development of Shaanxi Province(No.2022ZDLSF06-02).; Gynostemma pentaphyllum(Thunb.)Makino is a perennial creeping herbaceous plant in the family Cucurbitaceae,which has great medicinal value and commercial potential,but urgent conservation efforts are needed due to the...; 关键词：EVOLUTION jointly breeding

Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice被引量：3: 《Food Science and Human Wellness》2022年第5期1347-1354,共8页Mengxue Song Dehong Tan Bin Li Yanqun Wang Lin Shi; supported by the National Natural Science Foundation of China(81602983)。; Gynostemma pentaphyllum,also called"Southern Ginseng"in China,is a traditional Asian folk medicinal plant.Gypenosides(Gps)are the biologically active constituents of G.pentaphyllum,which have been reported with hypogl...; 关键词：GYPENOSIDES Gynostemma pentaphyllum Diabetes Insulin resistance GLUCONEOGENESIS Adenosine monophosphate-activated protein kinase(AMPK)

绞股蓝中皂苷类与黄酮类化合物的分离与鉴定被引量：8: 《中华中医药杂志》2022年第1期401-406,共6页杨册翟新房段宇齐彦爽赵敏彤朴香兰; 国家自然科学基金面上项目(No.81673692);国家自然科学基金中韩合作项目(No.81511140297);北京市大学生创新训练计划项目(No.BEIJ2020110030)。; 目的:研究绞股蓝中皂苷类与黄酮类化合物的分离与鉴定。方法:采用硅胶、大孔树脂、中压柱色谱、半制备型HPLC及分析型HPLC等现代分离技术对绞股蓝的化学成分进行分离纯化,并根据其理化性质、UV、MS、NMR等方法进行结构鉴定。结果:从绞股...; 关键词：绞股蓝皂苷类化合物黄酮类化合物 gypenoside S5 分离纯化结构鉴定

保加利亚乳杆菌对绞股蓝皂苷Gypenoside XLⅥ的微生物转化被引量：5: 《食品科学》2014年第17期133-136,共4页刘慧敏高雅军曾鸣朴香兰; 国家自然科学基金面上项目(81274186); 目的:分析绞股蓝皂苷GypenosideⅩLⅥ的微生物转化产物。方法:利用益生菌德氏乳杆菌保加利亚亚种的脱脂牛奶培养基对GypenosideⅩLⅥ进行微生物转化,并利用液相色谱离子阱飞行时间串联质谱方法鉴定GypenosideⅩLⅥ的微生物转化产物。结...; 关键词：微生物转化绞股蓝 GYPENOSIDE ⅩLⅥ 德氏乳杆菌保加利亚亚种

绞股蓝皂苷成分的分离与鉴定被引量：11: 《食品安全质量检测学报》2013年第1期283-288,共6页刘慧敏杨静陈道金朴香兰; 国家自然科学基金项目(30973960;81011140347;81181240306;81274186)~~; 目的提取、分离、鉴定绞股蓝皂苷主要成分。方法利用硅胶柱色谱及反相半制备柱色谱等分离手段,分离、纯化绞股蓝皂苷成分,并用核磁共振波谱(1H-NMR、13C-NMR)、液相色谱离子阱飞行时间质谱(LCMS-IT-TOF)等方法鉴定化合物结构,并对相关...; 关键词：绞股蓝达玛烷类皂苷 GYPENOSIDE XLVI GYPENOSIDE LVI

绞股蓝热处理产物中活性成分的纯化与鉴定及其对A549细胞的抑制活性被引量：4: 《食品科学》2012年第23期23-26,共4页朴香兰杨静吴倩曾鸣刘慧敏; 国家自然科学基金项目(30973960;81011140347;81181240306;81274186); 目的:提取、分离、鉴定绞股蓝热处理产物中抑制肺癌A549细胞的活性成分。方法:绞股蓝叶在温度125℃、压力0.24MPa条件下,加热处理3h,用80%乙醇加热回流提取3h,利用活性跟踪方法,通过大孔树脂HP-20及反相柱等分离手段,分离抑制肺癌A549...; 关键词：热处理绞股蓝肺癌A549细胞达玛烷类皂苷 GYPENOSIDE L GYPENOSIDE LI

A New Triterpene Saponin from Gynostemma pentaphyllum被引量：9: 《Chinese Herbal Medicines》2010年第4期317-320,共4页SHI Lin1, CAO Jia-qing2, ZHAO Hong3, ZHAO Yu-qing2, 4 1. College of Food Science, Shenyang Agriculture University, Shenyang 110161, China 2. School of Traditional Chinese Materia Madica, Shenyang Pharmaceutical University, Shenyang 110016, China 3. Dalian University, Dalian 116622, China 4. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; E&T Modern Center for Natural Products of Liaoning Province of China (2006-19-10); Objective To study the triterpene saponins from Gynostemma pentaphyllum with antitumor activities. Methods The 75% EtOH extract of G. pentaphyllum was used for isolation by silica gel column chromatography and prepara...; 关键词：ANTITUMOR Gynostemma pentaphyllum GYPENOSIDE triterpene saponin

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