CANCERS

作品数：353被引量：2621H指数：17
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相关机构：中南大学南京医科大学教育部中国科学院更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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“Clone-specific”antibody-drug conjugates:an innovative strategy in the treatment of T-cell cancers
《Signal Transduction and Targeted Therapy》2024年第10期4149-4150,共2页Dennis Jungherz Philipp Lückemeier Marco Herling 
D.J.’s position is funded by the German JoséCarreras Leukemia Foundation(DJCLS 01 R/2023 to M.H.).P.L.is supported by the Clinician-Scientist program of the Medical Faculty of the University of Leipzig.The latter also provides the endowed professorship to M.H.
In a recent study published in Nature,Nichakawade et al.provided proof-of-principle data on innovative strategies to target and eliminate cancerous T-cells while sparing healthy T-lymphocytes,addressing the urgent cli...
关键词：TREATMENT eliminate mostly 
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies被引量：9
《Signal Transduction and Targeted Therapy》2023年第9期4082-4114,共33页Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou 
This work was supported by NSFC grants 82222015,82171001 and 81800928;Young Elite Scientist Sponsorship Program by CAST No.2020QNRC001;Research Funding from West China School/Hospital of Stomatology Sichuan University RCDWJS2023-(1).
The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade i...
关键词：HOMEOSTASIS THERAPIES TARGETED 
Targeting epigenetic regulators to overcome drug resistance in cancers被引量：12
《Signal Transduction and Targeted Therapy》2023年第3期1070-1093,共24页Nan Wang Ting Ma Bin Yu 
This work is supported by the National Natural Science Foundation of China(nos.22277110,81973177,and 81903770);Natural Science Foundation of Henan Province(no.222300420069);Program for Science&Technology Innovation Talents in Universities of Henan Province(no.21HASTIT045);Key scientific and technological projects of Henan Province(no.222102310125);China Postdoctoral Science Foundation(No.2019M662556).
Drug resistance is mainly responsible for cancer recurrence and poor prognosis.Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.As the common epigenetic regula...
关键词：EPIGENETIC drug OVERCOME 
The cGAS-STING pathway:a therapeutic target in chromosomally unstable cancers被引量：1
《Signal Transduction and Targeted Therapy》2023年第2期338-340,共3页Haiyan Yan Weiguo Lu Fangwei Wang 
This work was supported by grants from the National Key Research and Development Program of China(2022YFA1105200,2022YFA1303100);the National Natural Science Foundation of China(32025011,32270772,31771499,and 32061160470);Natural Science Foundation of Zhejiang Province(LZ19C070001,LY17C070003).We also thank Dr.Qinfu Chen for the help to draft the artwork.
In a recent study published in Nature,Hong et al.revealed that the cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)innate immune pathway is critically required for the IL-6-dependent survival of chr...
关键词：UNSTABLE CHROMOSOMAL THERAPEUTIC 
Wnt/β-catenin signaling in cancers and targeted therapies被引量：65
《Signal Transduction and Targeted Therapy》2021年第9期2770-2793,共24页Fanyuan Yu Changhao Yu Feifei Li Yanqin Zuo Yitian Wang Lin Yao Chenzhou Wu Chenglin Wang Ling Ye 
The work is supported by the National Natural Science Foundation of China 81825005;State Key Laboratory of Oral Diseases SKLOD202007(L.Y.).
Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals.Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence,advanc...
关键词：CANCERS MORTALITY INCREMENT 
Aberrantly high activation of a FoxM1-STMN1 axis contributes to progression and tumorigenesis in FoxMl-driven cancers被引量：1
《Signal Transduction and Targeted Therapy》2021年第3期851-863,共13页Jun Liu Jipeng Li Ke Wang Haiming Liu Jianyong Sun Xinhui Zhao Yanping Yu Yihuan Qiao Ye Wu Xiaofang Zhang Rui Zhang Angang Yang 
supported by the National Natural Science Foundation of China(grantnumbers 81630069,81421003,31771439,81773262,81572763,81672751);the National Key Research and Development Program(grant number 2016YFC1303200);the Key Research and Development Program of Shaanxi(2019SF-010);Opening Projects of the State Key Laboratory of Cancer Biology(CBSKL201703,CBSKL201704,CBSKL201726)。
Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-bin...
关键词：cancer CHEMOTHERAPY clinical 
Identification and characterization of mammaglobin-A epitope in heterogenous breast cancers for enhancing tumor-targeting therapy被引量：1
《Signal Transduction and Targeted Therapy》2020年第1期1778-1788,共11页Zhiqiang Liu Xiqin Yang Cuimi Duan Jiangxue Li Rongsheng Tong Yuting Fan Jiannan Feng Ruiyuan Cao Wu Zhong Xiaoyan Feng Heqiu Zhang Lulu Cai 
supported by the National Nature Science Foundation of China(81672607 and 81500077);the National Key Specialty Construction Project of Clinical Pharmacy(30305030698);the Nature Science Foundation of Beijing(7192143),the Beijing Nova Program(Z171100001117115);the Special Foundation for State Major Research Program of China(2016YFC0106603);the Research Funding of Sichuan Provincial People’s Hospital(2017LY08).
Although targeted therapy has been extensively investigated for breast cancers,a molecular target with broad application is currently unavailable due to the high heterogeneity of these cancers.Mammaglobin-A(Mam-A),whi...
关键词：BREAST CANCERS EPITOPE 
The role of histone methylation in the development of digestive cancers:a potential direction for cancer management被引量：6
《Signal Transduction and Targeted Therapy》2020年第1期1226-1238,共13页Yuan Chen Bo Ren Jinshou Yang Huanyu Wang Gang Yang Ruiyuan Xu Lei You Yupei Zhao 
supported by the National Nature Science Foundation of China(2019,81972321 to L.Y.;2019,81974376 to Y.P.Z.).
Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality.Histone methylation,which is mediated mainly by lysine methyltransferases,lysine demethylases,an...
关键词：INVASION MORTALITY DIGESTIVE 
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