云南高校图书馆联盟文献共享服务平台- PRION

PRION: 作品数：173被引量：154H指数：5; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：朱钦士赵德明周筠梅练富林柯莎更多>>; 相关机构：中国农业大学中国科学院南加州大学厦门大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国科学院知识创新工程重要方向项目更多>>

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds: 《Neural Regeneration Research》2025年第4期1009-1014,共6页Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa; supported by Telethon Italy award GGP15225(to RC and GM);Italian Ministry of Health award RF-2016-02362950(to RC and CZ);the CJD Foundation USA(to RC);the Associazione Italiana Encefalopatie da Prioni(AIEnP)(to RC).; PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals.PrPSccan adopt different patho...; 关键词：anti-prion drug anti-PrPC antibody antisense oligonucleotide NEURODEGENERATION pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Astrocyte in prion disease: a double-edged sword被引量：2: 《Neural Regeneration Research》2022年第8期1659-1665,共7页Waqas Tahir Simrika Thapa Hermann M.Schatzl; supported by grants from Alberta Innovates/Alberta Prion Research Institute(APRI grants 201600010 and 201900008)(to HMS);ST had received a University of Calgary Eyes High,Killam and Alberta Innovates Health Solution(AIHS)doctoral fellowship.; Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein(PrPC)into the pathologic isoform PrPSc.Pathologic hallmarks of prion d...; 关键词：Alzheimer’s disease ASTROCYTES central nervous system Creutzfeldt-Jakob disease glial cells NEURODEGENERATION PRION prion disease prion protein SCRAPIE

Prion protein in myelin maintenance: what does the goat say?: 《Neural Regeneration Research》2021年第6期1216-1217,共2页Fredrik S.Skedsmo Arild Espenes Michael A.Tranulis; supported by grants from the Norwegian University of Life Sciences and The Research Council of Norway(227386/E40).; The cellular prion protein PrPC has been extensively studied because it can adopt a pathogenic three-dimensional conformation that causes rare,but invariably fatal,neurodegenerative prion diseases in humans and other ...; 关键词：PRION CONVERT INVAR

Saccharomyces cerevisiae in neuroscience:how unicellular organism helps to better understand prion protein?被引量：1: 《Neural Regeneration Research》2021年第3期489-495,共7页Takao Ishikawa; funded by the Polish National Science Centre MINIATURA3,grant No.501/66 GR-6220(to TI)。; The baker's yeast Saccharomyces(S.)cerevisiae is a single-celled eukaryotic model organism widely used in research on life sciences.Being a unicellular organism,S.cerevisiae has some evident limitations in application...; 关键词：amyloid artificial prion baker's yeast budding yeast drug screening fusion protein neurodegenerative diseases prion protein yeast-based assay

Prion-like domain disease-causing mutations and misregulation of alternative splicing relevance in limb-girdle muscular dystrophy (LGMD) 1G被引量：1: 《Neural Regeneration Research》2020年第12期2239-2240,共2页Cristina Batlle Salvador Ventura; Human prion-like proteins often correspond to nucleic acid binding proteins,displaying both globular domains and long intrinsically disordered regions(IDRs)(Harrison and Shorter,2017).Their IDRs are of low complexity ...; 关键词：DYSTROPHY MUSCULAR amyloid

The metabolome identity:basis for discovery of biomarkers in neurodegeneration被引量：1: 《Neural Regeneration Research》2019年第3期387-390,共4页Julie-Myrtille Bourgognon Joern R.Steinert; Neurodegenerative disorders are often associated with cellular dysfunction caused by underlying protein-misfolding signalling. Numerous neuropathologies are diagnosed at late stage symptomatic changes which occur in r...; 关键词：METABOLOME NEURODEGENERATION NEUROINFLAMMATION NITRIC oxide redox stress biomarker misfolded protein PRION disease

Blood exosomes as a tool for monitoring treatment efficacy and progression of neurodegenerative diseases: 《Neural Regeneration Research》2019年第1期72-74,共3页Hanin Abdel-Haq; Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,amyotrophic lateral sclerosis,and prion disease are representative neurodegenerative diseases that share common sub-cellular features,the most obvious of...; 关键词：疾病治疗功效 CELLULAR 工具 PRION 蛋白质大脑

Peptide aptamer-mediated modulation of prion protein α-cleavage as treatment strategy for prion and other neurodegenerative diseases被引量：1: 《Neural Regeneration Research》2018年第12期2108-2110,共3页Antonia N.Klein Erica Corda Sabine Gilch; funded by grants from the Alberta Prion Research Institute;the Alzheimer Society of Alberta and Northwest Territories;the Natural Sciences and Engineering Research Council(NSERC)of Canada;supported by the Canada Research Chair program;a postdoctoral fellowship from the German Research Foundation(DFG); Despite intensive research,most neurodegenerative diseases cannot be cured and for some of them no treatment is available to increase survival or quality of life.Among the latter are prion diseases,fatal and transmiss...; 关键词：Peptide aptamer-mediated modulation of prion protein cleavage as treatment strategy for prion and other neurodegenerative diseases

Targeting prion-like protein spreading in neurodegenerative diseases: 《Neural Regeneration Research》2018年第11期1875-1878,共4页Zhaohui Zhang Shuke Nie Liam Chen; The infectious template-mediated protein conversion is a unique mechanism for the onset of rare and fatal neurodegenerative disorders known as transmissible spongiform encephalopathies, or prion diseases, which affect...; 关键词：prion-like SYNUCLEIN tau TAR DNA-binding protein 43 BETA-AMYLOID Parkinson＇s disease frontotemporal dementia amyotrophic lateral sclerosis Alzheimer＇s disease NEURODEGENERATION

Natural polyphenols effects on protein aggregates in Alzheimer＇s and Parkinson＇s prion-like diseases被引量：3: 《Neural Regeneration Research》2018年第6期955-961,共7页aline freyssin guylène page bernard fauconneau agnès rioux bilan; Alzheimer＇s and Parkinson＇s diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposit...; 关键词：natural polyphenols protein aggregates Alzheimer＇s disease amyloid peptide amyloid plaques hyperphosphorylated tau Parkinson＇s disease a-synuclein synphilin-I

PRION