ARTESUNATE

作品数:73被引量:225H指数:8
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相关领域:医药卫生更多>>
相关作者:姚丽谢红靳秋月陈立军王静更多>>
相关机构:武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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相关基金:国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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Effect of artesunate on reducing renal and intestinal injury after cardiopulmonary resuscitation in porcine
《China Medical Abstracts(Internal Medicine)》2023年第4期201-202,共2页章杰 
Objective To investigate the effect of artesunate(ART)on renal and intestinal injury aftercardiopulmonary resuscitation(CPR)in porcine,and to explore its mechanism.Methods A total of 24 healthy male white porcines wer...
关键词:RESUSCITATION ARTESUNATE mechanism 
Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate被引量:6
《Acta Pharmacologica Sinica》2023年第9期1801-1814,共14页Xue-ling He Jia-yun Chen Yu-lin Feng Ping Song Yin Kwan Wong Lu-lin Xie Chen Wang Qian Zhang Yun-meng Bai Peng Gao Piao Luo Qiang Liu Fu-long Liao Zhi-jie Li Yong Jiang Ji-gang Wang 
support from the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research (2020YFE0205100);the National Key Research and Development Program of China (2020YFA0908000 and 2022YFC2303600);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202002);the National Natural Science Foundation of China (82141001,82274182,82074098 and 82173914);the CACMS Innovation Fund (CI2021A05101 and CI2021A05104);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (CI2021B014);the Science and Technology Foundation of Shenzhen (JCYJ20210324115800001);the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010 and ZZ15-ND-10);the Shenzhen Governmental Sustainable Development Fund (KCXFZ20201221173612034);the Shenzhen Key Laboratory of Kidney Diseases (ZDSYS201504301616234);the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (SZGSP001).
Liver,as an immune and detoxification organ,represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis.Artesunate(ART)is an anti-malaria agent,th...
关键词:SEPSIS scRNA-seq ARTESUNATE liver hepatic endothelial cells macrophages LYMPHOCYTES NEUTROPHILS 
Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjogren's syndrome被引量:5
《Signal Transduction and Targeted Therapy》2022年第9期3210-3212,共3页Fan Xiao Ke Rui Man Han Liyun Zou Enyu Huang Jie Tian Lijun Zhang Quan Jiang Yuzhang Wu Liwei Lu 
This work was supported by Chongqing International Institute for Immunology(2020YJC10);National Natural Science Foundation of China(82071817,82171771,82004171,81971542);Shenzhen Science and Technology Program(YCYJ20210324114602008);Young Elite Scientist Sponsorship Program by CACM(CACM-2020-QNRC2-05);Hong Kong Research Grants Council(17113319,17103821);RGC Theme-based Research Scheme(TRS)(T12-703/19-R);the Centre for Oncology and Immunology under the Health@InnoHK Initiative funded by the Innovation and Technology Commission,The Government of Hong Kong SAR,China.
Dear Editor,Primary Sjogren's syndrome(pSS)is an autoimmune disease characterized by dry eyes and dry mouth caused by glandular inflammation in salivary glands(SG)and lacrimal glands.Currently,pSS patients are sufferi...
关键词:TH17 SJOGREN INHIBITING 
Artesunate inhibits proliferation and migration of RPE cells and TGF-β2 mediated epithelial mesenchymal transition by suppressing PI3K/AKT pathway被引量:7
《International Journal of Ophthalmology(English edition)》2022年第2期197-204,共8页Zi-Yi Wang Yu Zhang Ling-Dan Wu Jie Chen Mei-Ling Chen Ci-Min Chen Qi-Hua Xu 
AIM:To study the braking effectiveness of artesunate on transforming growth factor(TGF)-β2 mediated epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE)in vitro.METHODS:The fostered ARPE-19 cells ...
关键词:proliferative vitreoretinopathy ARTESUNATE epithelial-mesenchymal transition MIGRATION 
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics被引量:18
《Acta Pharmaceutica Sinica B》2021年第2期322-339,共18页David Dolivo Pamela Weathers Tanja Dominko 
Award Number NIH-2R15AT008277-02(USA)from the National Center for Complementary and Integrative Health that provided funding to Pamela Weathers for some of the artemisinin bioavailability studies described and cited herein
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world.Despite considerable research,few therapies have proven effective and bee...
关键词:Fibrosis ARTEMISIA ARTEMISININ ARTESUNATE FIBROBLAST MYOFIBROBLAST Scar TGF-β 
Research Progress on Artemisinin and Its Derivatives against Hematological Malignancies被引量:1
《Chinese Journal of Integrative Medicine》2020年第12期947-955,共9页LI Ying SHAN Ning-ning SUI Xiao-hui 
Supported by the National Natural Science Foundation of China(No.81570104);Key Research and Development Project of Shandong Province(No.2015GSF118025,2015GSF118058,2016GSF201026)。
Although current therapeutic methods against hematological malignancies are effective in the early stage,they usually lose their effectiveness because of the development of drug resistances.Seeking new drugs with sign...
关键词:ARTEMISININ ARTESUNATE DIHYDROARTEMISININ hematological malignancies REVIEW 
Artesunate attenuate chronic graft-versushost disease by regulating Th17/Treg balance
《China Medical Abstracts(Internal Medicine)》2019年第2期119-120,共2页CHEN Xiaomei 
Objective To investigate the effects of artesunatetreatment on chronic graft-versus-host disease(cGVHD). Methods Recipient BALB /c mice received8 × 106 bone marrow cells with 8 × 106 spleen cells fromB10D2 mice. Art...
关键词:ARTESUNATE attenuate CHRONIC graft-versushost disease REGULATING TH17/TREG BALANCE cGVHD 
Publication process involving the discovery of artemisinin (qinghaosu) before 1985被引量:1
《Asian Pacific Journal of Tropical Biomedicine》2016年第6期461-467,共7页Man-Yuan Wang 
All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yua...
关键词:INTERESTED references PUBLICATION ARTESUNATE NOBEL INVENTION dedicated honored titled Figure 
Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis被引量:10
《World Journal of Gastroenterology》2016年第10期2949-2959,共11页Yun-Xia Chen Li-Na Lai Hui-Ying Zhang Yang-Hui Bi Li Meng Xu-Jiong Li Xiao-Xia Tian Li-Min Wang Yi-Min Fan Zhong-Fu Zhao De-Wu Han Cheng Ji 
Supported by the National Natural Science Foundation of China;No.81070339;the International Science and Technology Cooperation Project of Shanxi;No.2010081068;the Key Laboratory Foundation of Cellular Physiology Department of Shanxi Medical School and Provincial Ministry of Education;No.2010-09;the Fund for Returned Students of Shanxi;No.211-091;the Fund for Returned Medical Doctors of Changzhi Medical College;No.2010-01;Science and Technology Innovation Team Project of Changzhi Medical College;No.CX201409;College Student Innovation and Entrepreneurship Training Project of Shanxi Province;No.2014308;the US NIH(to Cheng Ji);No.R21AA023952 and No.P30DK48522-21
AIM: To evaluate the effect of artesunate(AS) supplementation on bacterial translocation(BT) and gut microbiota in a rat model of liver cirrhosis. METHODS: Fifty-four male Sprague-Dawley rats were randomly divided int...
关键词:Hepatic cirrhosis GUT MICROBIOTA Bacterial TRANSLOCATION ARTESUNATE Intervention 
Cover story
《Acta Pharmaceutica Sinica B》2016年第2期99-,共1页
Front Discovered by Youyou Tu,one of the 2015 Nobel Prize winners in Physiology or Medicine,together with many other Chinese scientists,artemisinin,artemether and artesunate,as well as other artemisinins,have brought ...
关键词:story ARTESUNATE LIVES millions MEDICINES DECOCTION ALKALOID methanol hundreds SAVING 
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