ARTESUNATE

作品数：73被引量：225H指数：8
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相关领域：医药卫生更多>>
相关作者：姚丽谢红靳秋月陈立军王静更多>>
相关机构：武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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  • 学科=医药卫生—临床医学x
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NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
A self-assembled nanomicelle-based "one stone for two birds" strategy for precision therapy of hepatic ischemia-reperfusion injury
《Nano Research》2025年第2期627-640,共14页Mengyuan Yu Jiongjie Yu Yujie Zhou Zhi Liang Hong Tang Changbiao Li Qingyang Que Hangxiang Wang Haiyang Xie Xiao Xu 
This research gained support from the National Key Research and Development Program of China(No.2021YFA1100500);the Major Research Plan of the National Natural Science Foundation of China(No.92159202);the National Natural Science Foundation of China(Nos.32171368 and 81930016);State Key Laboratory for Diagnosis and Treatment of Infectious Diseases(No.zz202310);the Non profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023-PT320-02);the International Science and Technology Cooperation Project of Zhejiang province.
Hepatic ischemia-reperfusion injury(IRI)is an intricate and inevitable physiological event occurred in the liver transplantation(LT)and it is of paramount importance to devise novel and efficient methods to ameliorate...
关键词：carvacrol(CAR) artesunate(ART) nanoparticles ischemia-reperfusion injury(IRI) ferroptosis 
Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis
《Journal of Clinical and Translational Hepatology》2024年第1期36-51,共16页Yingqian Wang Yujia Li Yangling Qiu Min Shen Ling Wang Jiangjuan Shao Feng Zhang Xuefen Xu Zili Zhang Mei Guo Shizhong Zheng 
supported by the National Natural Science Foundation of China(No.82000572,82073914,82173874,82274185);the Natural Science Foundation of Jiangsu Province(No.BK20220467,BK20200840);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.22KJB310013,19KJA310005);the Joint Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical(No.JKLPSE202005);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.NZY82000572);Nanjing Pharmaceutical Association-Changzhou Fourth Pharmaceutical Hospital Pharmaceutical Research Fund(NO.2021YX030);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX22_0792).
Background and Aims:Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells(HSCs)and leads to a poor outcome.Artesunate(Art)is an ester derivative of artemisinin that can induce ...
关键词：Ferroptosis Liver fibrosis Antioxidant system ATF3 ROCK1 
The Combination of Artesunate and Paclitaxel in 1:1 Ratio Induces Apoptosis and Morphology Change on Human Prostate Cancer Cell Lines
《Pharmacology & Pharmacy》2023年第11期482-492,共11页Juan Fabian Taylor Pierce Shenell Brown Jazmyne Smith Dolapo Adedeji Gloria Payne 
The combination of Artesunate (ART) and Paclitaxel (PTX) in two human prostate cancer (PCa) cell lines (PC-3 and LNCaP) was evaluated to investigate the effects on proliferation, apoptosis and morphological changes. T...
关键词：COMBINATION Prostate Cancer ARTESUNATE PACLITAXEL Anticancer Activities 
Research progress of artesunate in diabetes and its complications
《Traditional Medicine Research》2023年第5期44-51,共8页Yuan-Hui Guo Lu-Lu Chen Ying LI Jia-Jia Duan Chuan-Xin Liu Hong-Wei Jiang 
Diabetes is a metabolic disease characterized by abnormally elevated blood glucose levels.Persistent hyperglycemia leads to diabetic nephropathy,diabetic retinopathy,diabetes with periodontal disease and other diabeti...
关键词：ARTESUNATE DIABETES diabetic complications islet cells glycolipid metabolism ANTI-INFLAMMATORY IMMUNOREGULATION 
Retinal safety and toxicity study of artesunate in vitro and in vivo
《Advances in Ophthalmology Practice and Research》2023年第2期47-54,共8页Bing-Wen Lu Yu-Xiang Liang Jin-Feng Liu Zhong-Qing Sun Kwok-Fai So Kin Chiu 
supported by Midstream Research Programme for Universities,Hong Kong to Kin Chiu(Project No:MRP-092–17X).
Background:Artesunate(ART),a member of the artemisinin family,possesses multi-properties,including antiinflammation,anti-oxidation,and anti-tumor.ART was recently reported to show anti-neovascularization effect on the...
关键词：ARTESUNATE SAFETY RETINA MICROGLIA 
Clinical Efficacy of Artemether-Lumefantrine Artesunate-Amodiaquine of Children from Three Chadian Provinces with Acute of Uncomplicated Falciparum malariae from 6 Months to 5 Years
《Advances in Infectious Diseases》2022年第4期788-798,共11页Issa Ramat Adam Nack Jacques Hamit Mahamat Alio Akono Ntonga Patrick Abakar Idriss Lawane Mahamat Ali Bolti 
Introduction: Artemisinin-based combination therapies are the first-line antimalarial drugs used to treat uncomplicated Plasmodium falciparum malaria in many endemic countries worldwide. In Chad, since the adoption of...
关键词：Plasmodium falciparum Artemeter-Lumefantrine Artesunate-Amodiaquine Efficacy Parasitological Density Hemoglobin Levels 
Comparison of Efficacy and Safety of Artemisinin-Based Combination Therapies for Treating Uncomplicated Falciparum Malaria in Sub-Saharan African Countries: An Update on the Changes in Efficacy Using Network Meta-Analysis
《Advances in Infectious Diseases》2022年第3期405-421,共17页Solange Whegang Youdom Roméo Simeu Tchouenkou Eugène-Patrice Ndong-Nguéma Leonardo K. Basco 
Background: Several artemisinin-based combination therapies (ACT) are available to treat uncomplicated malaria in Africa. The present study aimed to assess the ranking of their efficacy and tolerance. Methods: A datab...
关键词：Malaria Dihydroartemisinin-Piperaquine Artesunate-Amodiaquine EFFICACY Safety Network Meta-Analysis 
Artesunate Inhibited the Proliferation, Apoptosis and Multidrug Resistance of FOXP3 Gene in K562/ADR Cells
《外文科技期刊数据库(文摘版)医药卫生》2021年第12期061-062,共4页LIU Xiaolei MA Lidong 
Objective: to investigate the effects of inhibition of FOXP3 by artesunate on proliferation, apoptosis and multidrug resistance of chronic myeloid leukemia (CML) K562/ADR cell line by azithromycin. Methods: CML adr-re...
关键词：azithromycin resistant (ADR) cell line K562 / ADR strains ARTESUNATE 
A new paradigm for artesunate anticancer function:considerably enhancing the cytotoxicity via conjugating artesunate with aptamer被引量：3
《Signal Transduction and Targeted Therapy》2021年第10期2964-2966,共3页Yingying Li Yongbo Peng Yan Tan Wenjing Xuan Ting Fu Xue-Qiang Wang Weihong Tan 
supported by the National Key R&D Project of China(2018YFA0902300);NSFC grants(81602499,21827811,91753109);Hu-Xiang Young Talent Program from Hunan Province(2019RS2022).
Dear Editor,Artemisinin and its derivatives(AIDs)have recently been widely applied in cancer therapy as promising therapeutic agents owing to its hypotoxicity and special bioactivation pathways.Though numerous strateg...
关键词：ARTESUNATE considerably CYTOTOXICITY 
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