ARTESUNATE

作品数:73被引量:225H指数:8
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相关领域:医药卫生更多>>
相关作者:姚丽谢红靳秋月陈立军王静更多>>
相关机构:武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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相关基金:国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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The Combination of Artesunate and Paclitaxel in 1:1 Ratio Induces Apoptosis and Morphology Change on Human Prostate Cancer Cell Lines
《Pharmacology & Pharmacy》2023年第11期482-492,共11页Juan Fabian Taylor Pierce Shenell Brown Jazmyne Smith Dolapo Adedeji Gloria Payne 
The combination of Artesunate (ART) and Paclitaxel (PTX) in two human prostate cancer (PCa) cell lines (PC-3 and LNCaP) was evaluated to investigate the effects on proliferation, apoptosis and morphological changes. T...
关键词:COMBINATION Prostate Cancer ARTESUNATE PACLITAXEL Anticancer Activities 
Comparison of Efficacy and Safety of Artemisinin-Based Combination Therapies for Treating Uncomplicated Falciparum Malaria in Sub-Saharan African Countries: An Update on the Changes in Efficacy Using Network Meta-Analysis
《Advances in Infectious Diseases》2022年第3期405-421,共17页Solange Whegang Youdom Roméo Simeu Tchouenkou Eugène-Patrice Ndong-Nguéma Leonardo K. Basco 
Background: Several artemisinin-based combination therapies (ACT) are available to treat uncomplicated malaria in Africa. The present study aimed to assess the ranking of their efficacy and tolerance. Methods: A datab...
关键词:Malaria Dihydroartemisinin-Piperaquine Artesunate-Amodiaquine EFFICACY Safety Network Meta-Analysis 
Artesunate Inhibited the Proliferation, Apoptosis and Multidrug Resistance of FOXP3 Gene in K562/ADR Cells
《外文科技期刊数据库(文摘版)医药卫生》2021年第12期061-062,共4页LIU Xiaolei MA Lidong 
Objective: to investigate the effects of inhibition of FOXP3 by artesunate on proliferation, apoptosis and multidrug resistance of chronic myeloid leukemia (CML) K562/ADR cell line by azithromycin. Methods: CML adr-re...
关键词:azithromycin resistant (ADR) cell line K562 / ADR strains ARTESUNATE 
A new paradigm for artesunate anticancer function:considerably enhancing the cytotoxicity via conjugating artesunate with aptamer被引量:3
《Signal Transduction and Targeted Therapy》2021年第10期2964-2966,共3页Yingying Li Yongbo Peng Yan Tan Wenjing Xuan Ting Fu Xue-Qiang Wang Weihong Tan 
supported by the National Key R&D Project of China(2018YFA0902300);NSFC grants(81602499,21827811,91753109);Hu-Xiang Young Talent Program from Hunan Province(2019RS2022).
Dear Editor,Artemisinin and its derivatives(AIDs)have recently been widely applied in cancer therapy as promising therapeutic agents owing to its hypotoxicity and special bioactivation pathways.Though numerous strateg...
关键词:ARTESUNATE considerably CYTOTOXICITY 
Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis被引量:2
《Chinese Chemical Letters》2021年第4期1550-1554,共5页Chunmeng Ma Jinlong Zhang Yuan Zhang Chen Ma Minrui Ma Fanpeng Ran Xiaoyan Liu Haixia Zhang 
financially supported by the National Natural Science Foundation of China(No.21575055);the Fundamental Research Funds for the Central Universities(No.561220006)。
As a vital nutrient closely related to the cance r-cells proliferation,phosphate anions have been paid great attention as a promising anticancer agent.Generally,the transport of phosphate anions depends on a protein t...
关键词:Phosphate anions carrier Black phosphorus nanosheets ARTESUNATE Phosphate imbalance NECROSIS 
Enhanced lysosomal function is critical for paclitaxel resistance in cancer cells: reversed by artesunate被引量:2
《Acta Pharmacologica Sinica》2021年第4期624-632,共9页Zhe Li Yu-ting Zhu Min Xiang Jun-lan Qiu Shou-qing Luo Fang Lin 
supported by grants from the Natural Science Foundation of Jiangsu Province(No.BK20151233);the Scientific and Technological Innovation Team Building Program of Suzhou Vocational Health College(SZWZYTD201801);the Youth Project of Health and Family Planning Bureau of Suzhou New District(No.2017Q005);Suzhou industrial technology innovation(No.SYSD2016062);the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD).
The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells.Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells.Arte...
关键词:ARTESUNATE cisplatin-resistant human lung adenocarcinoma cells(A549/DDP) paclitaxel-resistant human lung adenocarcinoma cells(A549/TAX) doxorubicin-resistant human breast cancer cells(MCF-7/ADR) LYSOSOME TFEB 
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells被引量:8
《Acta Pharmacologica Sinica》2020年第12期1609-1620,共12页Xu Yao Chen-ru Zhao Hao Yin KeWei Wang Jian-jun Gao 
This project was supported by grants from the National Natural Science Foundation of China(81503094,81573410,and 81603071);the China Postdoctoral Science Foundation(2016M600524);and the Qingdao Postdoctoral Applied Research Project(2016072,Jian-jun Gao,Qingdao University).
Sorafenib is currently the standard chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC).But its efficacy requires improvement,it is imperative to seek therapeutic strategies that combine sorafeni...
关键词:SORAFENIB ERK ARTEMISININ ROS hepatocellular carcinoma STAT3 
Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression被引量:5
《Acta Pharmaceutica Sinica B》2019年第5期937-951,共15页Cai-Ping Chen Kun Chen Zhiqi Feng Xiaoan Wen Hongbin Sun 
supported by grants from the National Natural Science Foundation of China(grants 31501182,81573299 and81730094);the “111 Project” from the Ministry of Education of China to Hongbin Sun;the State Administration of Foreign Experts Affairs of China,China(No.111-2-07);Fundamental Research Funds for the Central Universities,China(2632017ZD05)
Artemisinin and its derivatives(ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors(HDACi) were known to be able to promote heme synthesis in erythroid c...
关键词:ARTESUNATE HDAC inhibitor HEME ALAS1 Antitumor 
Benefits of Artesunate versus Quinine in the Treatment of Children with Severe Malaria at the National University Teaching Hospital of Cotonou被引量:1
《Open Journal of Pediatrics》2017年第3期156-163,共8页Godonou Gratien Sagbo Laeticia Zohoun Gilles Bognon Joseph Agossou Caroline Padonou Yévèdo Tohodjèdé Florence Alihonou Blaise Ayivi 
Introduction: Severe malaria is one of the leading causes of death in Sub-Saharan African countries, and artesunate is recommended as a first-line treatment by the Word Heath Organization (WHO.). Objective: Identify t...
关键词:SEVERE MALARIA QUININE ARTESUNATE 
青蒿琥酯对肺癌A549细胞生物学行为的影响被引量:1
《中国药物与临床》2016年第7期968-970,I0002,共4页王静 韩福才 贺莉 师如意 杨斌 
目前,作为肺癌的常见治疗方法之一的化疗,由于其治疗过程中产生的耐药、化疗药物本身的毒副作用等原因,使得其效果已远不如从前,促使寻找更加安全有效的治疗药物成为当务之急。中药是我国医药文化的精粹,中药制剂抗肿瘤效应也越来越引...
关键词:青蒿琥酯 人肺癌细胞 细胞生物学 ARTESUNATE 四甲基偶氮唑盐 医药文化 化疗药物 抗肿瘤效应 毒副作用 细胞周期 
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