The combination of Artesunate (ART) and Paclitaxel (PTX) in two human prostate cancer (PCa) cell lines (PC-3 and LNCaP) was evaluated to investigate the effects on proliferation, apoptosis and morphological changes. T...
Background: Several artemisinin-based combination therapies (ACT) are available to treat uncomplicated malaria in Africa. The present study aimed to assess the ranking of their efficacy and tolerance. Methods: A datab...
Objective: to investigate the effects of inhibition of FOXP3 by artesunate on proliferation, apoptosis and multidrug resistance of chronic myeloid leukemia (CML) K562/ADR cell line by azithromycin. Methods: CML adr-re...
supported by the National Key R&D Project of China(2018YFA0902300);NSFC grants(81602499,21827811,91753109);Hu-Xiang Young Talent Program from Hunan Province(2019RS2022).
Dear Editor,Artemisinin and its derivatives(AIDs)have recently been widely applied in cancer therapy as promising therapeutic agents owing to its hypotoxicity and special bioactivation pathways.Though numerous strateg...
financially supported by the National Natural Science Foundation of China(No.21575055);the Fundamental Research Funds for the Central Universities(No.561220006)。
As a vital nutrient closely related to the cance r-cells proliferation,phosphate anions have been paid great attention as a promising anticancer agent.Generally,the transport of phosphate anions depends on a protein t...
supported by grants from the Natural Science Foundation of Jiangsu Province(No.BK20151233);the Scientific and Technological Innovation Team Building Program of Suzhou Vocational Health College(SZWZYTD201801);the Youth Project of Health and Family Planning Bureau of Suzhou New District(No.2017Q005);Suzhou industrial technology innovation(No.SYSD2016062);the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD).
The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells.Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells.Arte...
This project was supported by grants from the National Natural Science Foundation of China(81503094,81573410,and 81603071);the China Postdoctoral Science Foundation(2016M600524);and the Qingdao Postdoctoral Applied Research Project(2016072,Jian-jun Gao,Qingdao University).
Sorafenib is currently the standard chemotherapy drug for treatment of advanced hepatocellular carcinoma(HCC).But its efficacy requires improvement,it is imperative to seek therapeutic strategies that combine sorafeni...
supported by grants from the National Natural Science Foundation of China(grants 31501182,81573299 and81730094);the “111 Project” from the Ministry of Education of China to Hongbin Sun;the State Administration of Foreign Experts Affairs of China,China(No.111-2-07);Fundamental Research Funds for the Central Universities,China(2632017ZD05)
Artemisinin and its derivatives(ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors(HDACi) were known to be able to promote heme synthesis in erythroid c...
Introduction: Severe malaria is one of the leading causes of death in Sub-Saharan African countries, and artesunate is recommended as a first-line treatment by the Word Heath Organization (WHO.). Objective: Identify t...