MICROARRAY

作品数:440被引量:1533H指数:15
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相关领域:医药卫生生物学更多>>
相关作者:范保星吴德昌张开泰石磊黄圆更多>>
相关机构:清华大学复旦大学军事医学科学院北京大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家教育部博士点基金更多>>
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  • 学科=医药卫生—基础医学x
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High‐throughput formation of miniaturized cocultures of 2D cell monolayers and 3D cell spheroids using droplet microarray
《Droplet》2023年第1期36-46,共11页Haijun Cui Tina Tronser Xianxian Wang Janine Wesslowski Gary Davidson Anna A.Popova Pavel A.Levkin 
Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),Grant/Award Numbers:406232485,LE 2936/9‐1,331351713–SFB1324;Heidelberg Karlsruhe Strategic Partnership(HeiKa,Germany);Impuls‐und Vernetzungsfonds der Helmholtz‐Gemeinschaft。
Most of the biological processes,including cell signaling,cancer invasion,embryogenesis,or neural development,are dependent on and guided by the complex architecture and composition of cellular microenvironments.Mimic...
关键词:INVASION architectures COCULTURE 
Sources of transcription variation in Plasmodium falciparum
《Journal of Genetics and Genomics》2022年第10期965-974,共10页Lindsey B.Turnbull Katrina A.Button-Simons Nestor Agbayani Michael T.Ferdig 
supported by Eck Institute for Global Health Fellowships;supported by the Indiana Clinical and Translational Sciences Institute(UL1TR001108)from the National Institutes of Health,National Center for Advancing Translational Sciences,Clinical and Translational Sciences Award;the support from the Center for Quantitative Biology(P50 GM071508)。
Variation in transcript abundance can contribute to both short-term environmental response and long-term evolutionary adaptation.Most studies are designed to assess differences in mean transcription levels and do not ...
关键词:Expression variation MALARIA TRANSCRIPTION CLONING MICROARRAY 
A reversible microarray immobilization strategy based on thiol-quinone reaction
《Chinese Chemical Letters》2022年第1期213-216,共4页Ling Feng Ping Wang Yi Feng Jie Zhang Qingxin Chen Yusheng Xie Jingdong Luo Jiang Xia Shao Q.Yao Hongyan Sun 
the financial support from the Research Grants Council of Hong Kong(Nos.11102719,11304118 and 14306317);Shenzhen Basic Research Project(No.JCYJ20160601173218804);National Natural Science Foundation of China(No.21778044);the Shandong University of Technology Ph.D.Startup Foundation(No.420033)。
Microarray technology has been widely applied in biomedical research.The key to microarray study is to develop efficient immobilization method.In this study,we designed a new reversible microarray immobilization metho...
关键词:Reversible Microarray BIOCHIP Thiol-quinone reaction Peptides Thiol-proteins 
Assessment and comparison of recombinant proteins from different sources for the detection of SARS-CoV-2 infection by using protein microarray被引量:2
《Acta Biochimica et Biophysica Sinica》2021年第2期262-264,共3页Huan Qi Mingliang Ma Danyun Lai Yang Li Fucheng Zhang Sheng-ce Tao 
This work was partially supported by the grants from the National Key Research and Development Program of China(No.2016YFA0500600);Open Foundation of Key Laboratory of Systems Biomedicine(Nos.KLSB2017QN-01 and KLSB2020QN-05).
COVID-19 (the COVID-19 is a type of disease and resulted from being infected by virus SARS-CoV-2) pandemic is threatening tens of millions of lives around the world [1]. To date, specific drugs or vaccines are still n...
关键词:DIAGNOSIS MICROARRAY DRUGS 
A microarray platform designed for high-throughput screening the reaction conditions for the synthesis of micro/nanosized biomedical materials被引量:3
《Bioactive Materials》2020年第2期286-296,共11页Xiaoyu Li Xiran Yang Lei Liu Peipei Zhou Jianhua Zhou Xuetao Shi Yingjun Wang 
financially supported by the Science and Technology Program of Guangdong Province(2019B010941002,2017B090911008,2016A030306018);the National Natural Science Foundation of China(No.51905557);Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110102001).
Materials research usually relies on lengthy and largely trial-and-error methods,high-throughput technology has thereby emerged as an alternative method which is proven to be a simple,rapid,accurate and sensitive tech...
关键词:MICROFLUIDICS HIGH-THROUGHPUT Concentration gradient Calcium phosphates 
1例性发育不全的遗传咨询
《中国产前诊断杂志(电子版)》2019年第4期107-108,共2页朱冬生 潘小英 吴菁 刘倩 卢建 郭莉 
性发育不全是遗传咨询中的常见问题[1-3]。本例病例为女性性发育不全,但患者自12岁起喜着男性装扮,外观貌似男性。因此在遗传咨询中要判断患者的生理性别,同时还应关心其心理问题。微阵列分析技术(chromosomal microarray analysis,CMA...
关键词:性发育不全 遗传咨询 生理性别 染色体变异 微阵列分析 MICROARRAY 常见问题 
染色体微阵列分析实验室技术要求专家共识被引量:10
《中华检验医学杂志》2019年第9期745-751,共7页 王治国 徐两蒲 黄海龙 
染色体微阵列分析(chromosomal microarray analysis,CMA),是以微阵列为技术基础的基因组拷贝数变异(copy number variations,CNVs)分析技术,主要包括基于比较基因组杂交的微阵列(array-based comparative genomic hybridization,aCGH)...
关键词:微阵列分析 染色体变异 实验室技术 MICROARRAY 专家 比较基因组杂交 单核苷酸多态性 遗传病诊断 
胃癌高通量组织芯片及切片制作经验技巧总结被引量:1
《解剖科学进展》2018年第2期216-218,220,共4页于继红 孙勖人 孙明军 
辽宁省科技厅博士启动基金(201501012)
利用术后病理蜡块组织样本切片染色是非常重要的研究方法之一,常见的如免疫组化,原位杂交等研究方法,定性或半定量检测组织中蛋白或基因的表达。然而蜡块组织的切片过程对组织造成一定的消耗和破坏,不利于术后病理存档保存,限制了其研...
关键词:组织芯片 切片制作 经验技巧 MICROARRAY 高通量 胃癌 组织样本 术后病理 
Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine被引量:1
《World Journal of Gastroenterology》2017年第41期7369-7386,共18页Finbarr O’Sullivan Joanne Keenan Sinead Aherne Fiona O’Neill Colin Clarke Michael Henry Paula Meleady Laura Breen Niall Barron Martin Clynes Karina Horgan Padraig Doolan Richard Murphy 
Supported by A Strategic Alliance Programme between Alltech Ltd. and DCU and also Enterprise Ireland Innovation Partnership Grant(IP 2015 0375)
AIM To identify mi RNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the intestine.METHODS Exponentially growing Caco-2 and HT-29 cells were harvested and prepa...
关键词:CACO-2 HT-29 MICROARRAY PROTEOMICS miRNA Targetscan Gene ontology 
铜绿假单胞菌PA0861突变菌株表达谱检测分析被引量:6
《中国病原生物学杂志》2017年第6期495-499,504,共6页李九龙 郭嘉义 张燕 陈一帆 满耕孝 黄卫东 
国家自然科学基金项目(No.81260243)
目的分析铜绿假单胞菌野生型菌株PAO1及PA0861突变菌株基因表达谱,探讨铜绿假单胞菌中GGDEFEAL基因PA0861的生物学功能。方法以野生型铜绿假单胞菌PAO1及PA0861基因转座子插入失活的突变体菌株为材料,利用结晶紫染色方法进行细菌生物膜...
关键词:铜绿假单胞菌 C-DI-GMP MICROARRAY 生物膜 铁载体 
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