INFLAMMASOME

作品数：391被引量：2615H指数：23
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相关领域：医药卫生更多>>
相关作者：韩蓉吴东明吴玉章许颖陈永文更多>>
相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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  • 期刊=Chinese Journal of Integrative Medicinex
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Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway
《Chinese Journal of Integrative Medicine》2025年第2期118-130,共13页LI Zhu-qing ZHANG Feng LI Qi WANG Li SUN Xiao-qiang LI Chao YIN Xue-mei LIU Chun-lei WANG Yan-xin DU Xiao-yu LU Cheng-zhi 
Supported by the National Natural Science Foundation of China(No.82300445);the Natural Science Foundation of Tianjin(No.22JCQNJC01130);the Medical Health Science and Technology Project of Tianjin Municipal Health Commission(No.TJWJ2023QN026)。
Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,ai...
关键词：endothelial dysfunction GENTIOPICROSIDE NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine 
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy被引量：1
《Chinese Journal of Integrative Medicine》2025年第1期19-27,共9页LIU Tian-yi HAO Yu MAO Qin ZHOU Na LIU Meng-hua WU Jun WANG Yi YANG Ming-rui 
Supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A00601 and CI2021B017-09)。
Objective: To investigate the inhibitory effect of Tanreqing Injection(TRQ) on the activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3) inflammasome in macrophages inf...
关键词：Tanreqing Injection influenza virus ANTI-INFLAMMATION MITOPHAGY nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome Chinese medicine 
Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway
《Chinese Journal of Integrative Medicine》2024年第11期1027-1034,共8页GUO Fan HAN Xiao YOU Yue XU Shu-juan ZHANG Ye-hao CHEN Yuan-yuan XIN Gao-jie LIU Zi-xin REN Jun-guo CAO Ce LI Ling-mei FU Jian-hua 
Supported by the Youth Planning Project of Beijing Scienceand Technology Development Fund for Chinese Medicine(No.QN-2020-14);innovation Fund of China Academy of ChineseMedical Sciences(No.CI2021A00912);Scientific Fund ofNational Clinical Research Center for Chinese Medicine Cardiology(No.CMC2022005)。
Objective:To observe the protective effect and mechanism of hydroxyl safflower yellow A(HsYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs).Methods:HUVECs were treated wi...
关键词：NLRP3 inflammasome hydroxysafflor yellow A Chinese medicine human umbilical vein endothelial cells PYROPTOSIS myocardial reperfusion injury oxygen-glucose deprivation reperfusion 
Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine被引量：2
《Chinese Journal of Integrative Medicine》2024年第5期468-479,共12页ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie 
Supported by the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine (No.2020149)。
Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in ...
关键词：PYROPTOSIS cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms 
Polypeptide from Moschus Suppresses Lipopolysaccharide-Induced Inflammation by Inhibiting NF-κB-ROS/NLRP3 Pathway
《Chinese Journal of Integrative Medicine》2023年第10期895-904,共10页YI Jing LI Li YIN Zhu-jun QUAN Yun-yun TAN Rui-rong CHEN Shi-long LANG Ji-rui LI Jiao ZENG Jin LI Yong SUN Zi-jian ZHAO Jun-ning 
the Establishment of Key Disciplines of Traditional Chinese Medicine in Sichuan Province-Pharmacology of Chinese Materia Medica(No.2020ZDXK01);the Systemic Research and Development of Moschus(No.D-2019-6 and D-2019-8)。
Objective To examine the anti-inflammatory effects and potential mechanisms of polypeptide from Moschus(PPM)in lipopolysaccharide(LPS)-induced THP-1 macrophages and BALB/c mice.Methods The polypeptide was extracted fr...
关键词：MOSCHUS POLYPEPTIDE INFLAMMATION NLRP3 inflammasome thioredoxin interacting protein nuclear factorκB Chinese medicine 
Progress on Regulation of NLRP3 Inflammasome by Chinese Medicine in Treatment of Ulcerative Colitis被引量：1
《Chinese Journal of Integrative Medicine》2023年第8期750-760,共11页SUN Hao-xian ZHU Ying 
the National Natural Science Foundation of China(No.81874466);Hunan Clinical Medical Technology Innovation Guidance Project(No.2021SK51406);Hunan University of Chinese Medicine Postgraduate Innovation Project(No.2022CX35)。
Ulcerative colitis(UC)is a chronic,non-specific intestinal disease that not only affects the quality of life of patients and their families but also increases the risk of colorectal cancer.The nucleotide-binding oligo...
关键词：NLRP3 inflammasome ulcerative colitis Chinese medicine mechanism of action review 
Effect of Berberine on Activation of TLR4-NFκB Signaling Pathway and NLRP3 Inflammasome in Patients with Gout被引量：6
《Chinese Journal of Integrative Medicine》2023年第1期10-18,共9页DANG Wan-tai XU Dan ZHOU Jing-guo 
Supported by the Innovative Team Building Project of Chengdu Medical College(No.CYTD18-03);the Key Projects of the First Affiliated Hospital of Chengdu Medical College(No.CYFY2019ZD01);Project of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2020JC0023)。
Objective:To determine the effects of berberine(BBR) on the activation of toll-like receptor 4(TLR4),nuclear factor(NF) κB(NF-κB) signaling and NLRP3 inflammasome in patients with gout.Methods:Peripheral blood monon...
关键词：BERBERINE GOUT TLR4-NF-κB NLRP3 inflammasome monosodium urate 
Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome:A Narrative Review被引量：5
《Chinese Journal of Integrative Medicine》2022年第8期753-761,共9页YUAN Jia-yao FU Yu FENG Zhi-hai SANG Feng SHAO Ming-yi LI Lei-lei 
Supported by National Natural Science Foundation of China(No.81704011);Special Scientific Research Project of National Traditional Chinese Medicine Clinical Research Base of Henan Provincial Health Commission(No.2019JDZX2026)。
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 i...
关键词：Chinese medicine diabetic atherosclerosis NLRP3 inflammasome INTERLEUKIN-1Β TXNIP pyroptosis 
Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage被引量：3
《Chinese Journal of Integrative Medicine》2022年第7期594-602,共9页CHEN Song DING Yi-hang SHI Song-sheng TU Xian-kun 
Supported by the Natural Science Foundation of Fujian Province of China (No. 2020J011016);the Joint Funds for the Innovation of Science and Technology of Fujian Province (No. 2018Y9004);the Startup Fund for Scientific Research of Fujian Medical University (No. 2019QH1055)。
Objective: To determine whether Schisandrin B(Sch B) attenuates early brain injury(EBI) in rats with subarachnoid hemorrhage(SAH). Methods: Sprague-Dawley rats were divided into sham(sham operation), SAH, SAH+vehicle,...
关键词：schisandrin B subarachnoid hemorrhage early brain injury inflammation neuronal apoptosis nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 Chinese medicine 
Anti-inflammatory Effect of Total Saponin Fraction from Dioscorea nipponica Makino on Gouty Arthritis and Its Influence on NALP3 Inflammasome被引量：13
《Chinese Journal of Integrative Medicine》2019年第9期663-670,共8页ZHOU Qi YU Dong-hua ZHANG Ning LIU Shu-min 
Supported by the National Natural Science Foundation of China(Nos.81173618,81403156);China Postdoctoral Science Foundation(No.2015M57036);Heilongjiang Postdoctoral Special Assisted Fund(Nos.LBH-TZ0520,LBH-Z13191);Scientific Fund of Heilongjiang University of Chinese Medicine(No.2013bs05);the Outstanding Innovative Talent Support Programs of Heilongjiang University of Chinese Medicine
Objective: To investigate the mechanism of Chinese herbal medicine Dioscorea nipponica for the treatment of monosodium urate crystals-induced gouty arthritis(GA) in rats. Methods: Sixty male Wistar rats were divided i...
关键词：apoptosis-associated speck-like protein containing a caspase-recruitment domain caspase-1 Chinese medicine DIOSCOREA nipponica NALP3 
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