supported by the National Natural Science Foundation of China(22177042 and 22307048);The generous support from Beijing Municipal Commission of Science and Technology(L212015)was also highly appreciated.
With protoescigenin as starting material and through orchestrated application of Yu and Schmidt glycosylation protocols,the synthesis of acyl group-free escin derivatives was achieved for the first time.As the undesir...
support from the National Natural Science Foundation of China(21702013 and 22271010);the Fundamental Research Funds for the Central Universities(XK1802-6)at the BUCT.
A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(a...
supported by the National Natural Science Foundation of China(No.22171046);the Hundred-Talent Project of Fujian(No.50021113).
The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and agrochemicals.Herein,we disclose an electrochemical d...
the National Natural Science Foundation of China(Nos.21772138 and 21672157);the Natural Science Foundation of Jiangsu Province(BK20221356);PAPD。
A series of 3-acyl-substituted isoindolinone derivatives were synthesized in a one-pot manner via the reaction of o-bromobenzaldehydes,isocyanides,and carboxylic acids in the presence of palladium catalyst and base. T...
the National Natural Science Foundation of China(Nos.22001034 and 21804019);the Open Fund of the Jiangxi Province Key Laboratory of Synthetic Chemistry(No.JXSC202008);the Research Found of East China University of Technology(Nos.DHBK2019265,DHBK2019267,DHBK2019264)for financial support.
We report an exclusively tandem C—O and C—C bond forming beyond the esterification and cyclization reaction of 2-acylbenzoic acids with alcohols to regio-and stereoselective synthesis of the(Z)-3-ylidenephthalides.T...
Financial support for this work was gratefully received from the National Natural Science Foundation of China(Nos.22077080,21907064 and 91753102);the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2020YQ14).
Main observation and conclusion Selenoesters are useful substitutes for traditional thioesters in protein ligation chemistry due to their high reactivity in the trans-thio/selenoesterification reaction.However,existin...
A highly regio-, diastereo- and enantioselective addition of 2-acyl imidazoles or 2-acyl pyridines with allenes promoted by Rh/Lewis acid synergistically catalytic system is described. This atom economic approach lead...
A synergistic catalysis combination of chiral-at-metal rhodium complex and amine catalyst was developed for enantioselective alkylation of aldehydes with α,β-unsaturated 2-acyl imidazoles. The corresponding adducts ...
A convenient copper-catalyzed approach has been developed for the synthesis of substituted spiro-fused pyrazolin-5-ones from readily available cyclopropyl O-acyl ketoximes via an intramolecular N-N bond formation reac...
Project supported by the National Natural Science Foundation of China (Nos. 20025207, 20272071, 20372075 and 20321202), the Kn6wledge Innovation Project of the Chinese Academy of Sciences (No. KGCX2-SW-209), and the Major State Basic Research Development Program (No. G2000077502).
N-Acyl-β-hydroxy-4-phenyl-oxazolidinethiones could be rapidly converted into their ethyl thiol esters in high yields by treatment with EtSH at 0 ℃ in CH3CN or 9 : 1 (V : V) THF-H2O in the presence of a catalytic...