云南高校图书馆联盟文献共享服务平台- SPHINGOSINE

SPHINGOSINE: 作品数：80被引量：236H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张翼肖琼尹大力徐美林王菁更多>>; 相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>

Cystathionineγ-lyase-derived H_(2)S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase: 《Acta Pharmacologica Sinica》2024年第11期2366-2379,共14页You-tian Hu Zhi-wei Liu Tong-hui Zhang Yu-e Ma Lei He Jie Zhang Yue-yang Zhou Antonio Vidal-Puig De-jing Pan Fang Wu; supported by the National Natural Science Foundation of China(32271304,31500635,21834005,31771299);Research Fund of Medicine and Engineering of Shanghai Jiao Tong University(YG2021QN144);National Key R&D Program of China(2018YFA0801100);National Center for International Research of Genomics(2017B01012).; Thymic egress is a crucial process for thymocyte maturation,strictly regulated by sphingosine-1-phosphate lyase(S1PL).Recently,cystathionineγ-lyase(CSE),one of the enzymes producing hydrogen sulfide(H_(2)S),has emerg...; 关键词：immune cells thymic egress hydrogen sulfide S1P lyase redox motif NSC4056

Correction to:Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase: 《Cellular & Molecular Immunology》2018年第9期870-870,共1页Hsueh-Chun Wang Tzu-Hsuan Wong Li-Ting Wang Hsiang-Han Su Hsiu-Yueh Yu Ai-Hsuan Wu Yu-Chun Lin Hua-Ling Chen Jau-Ling Suen Shih-Hsien Hsu Li-Chen Chen Yufeng Zhou Shau-Ku Huang

Incorporation of Sphingosine 1-Phosphate Loaded Mesoporous Silica Nanoparticles into Poly ( L-lactic acid ) Nanofibrous Scaffolds for Bone Tissue Engineering: 《Journal of Donghua University(English Edition)》2017年第1期164-166,共3页秦明周小军张骞骞苗莹珂何创龙; National Natural Science Foundations of China(Nos.31271028,31570984);International Cooperation Fund of the Science and Technology Commission of Shanghai Municipality,China(No.15540723400);Open Foundation of State Key Laboratory for Modification of Chemical Fibers,Polymer Materials,China(No.LK1416);the Innovation Funds of Donghua University,China(No.15D310516);“111 Project” Biomedical Textile Materials Science and Technology,China(No.B07024); Controlled release of the functional factors is the key to improve clinical therapeutic efficacy during the tissue repair and regeneration. The thrce-dimensional （3D） scaffold can provide not only physical propertie...; 关键词：SCAFFOLD mesoporous silica nanoparticles sphingosine 1- phosphate （ALP） RELEASE

Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity被引量：8: 《Journal of Genetics and Genomics》2015年第11期613-624,共12页Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li; partially supported by the grants from the Ministry of Science & Technology-China (Nos.2014CB964600 and 2012CB966800);the National Science Foundation of China (Nos. 31301125 and 31071283);Shenzhen Peacock Plan (No. KQCX20130628112914292);Shenzhen Key Laboratory for Molecular Biology of Neural Development (No. ZDSY20120617112838879);SIAT Innovation Program for Excellent Young Researchers (No. 201404); Sphingosine-1-phosphate receptor 1 （S1PR1）, a G protein-coupled recep （GPCR）. controls vasct stability by stabilizing vascular endothelial （VE）-cadherin junctional localization and inhibiting vascular endothelia...; 关键词：Gαs VE-eadherin S1PR1 signaling adherens junctions vascular integrity

Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism被引量：17: 《Acta Pharmaceutica Sinica B》2015年第2期151-157,共7页Eric Kwong Yunzhou Li Phillip B.Hylemon Huiping Zhou; supported by A.D.Williams Award (to Huiping Zhou);National Institutes of Health (NIH,No.R01 DK-057543 to Phillip B.Hylemon and Huiping Zhou);supported by VA Merit Awards (No.1BX0013828-01 to Phillip B.Hylemon;No.1I01BX001390 to Huiping Zhou); The liver is the central organ involved in lipid metabolism. Dyslipidemia and its related disorders, including non-alcoholic fatty liver disease(NAFLD), obesity and other metabolic diseases, are of increasing public h...; 关键词：Bile acid Sphingosine-1 phosphate receptor Heptic lipid metabolism

Roles of sphingosine 1-phosphate on tumorigenesis被引量：5: 《World Journal of Biological Chemistry》2011年第2期25-34,共10页Hsinyu Lee; Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with a variety of biological activities.It is generated from the conversion of ceramide to sphingosine by ceramidase and the subsequent conversion of sphingosi...; 关键词：SPHINGOSINE 1-phosphate SPHINGOSINE KINASE CERAMIDE ANGIOGENESIS Autophagy TUMORIGENESIS

To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient被引量：3: 《World Journal of Biological Chemistry》2011年第1期1-13,共13页Andrew Hsu Jen-Fu Lee Daniel E Cramer Menq-Jer Lee; Supported by NIH HL071071 (Lee MJ); Most hematopoietic stem progenitor cells (HSPCs) reside in bone marrow (BM), but a small amount of HSPCs have been found to circulate between BM and tissues through blood and lymph. Several lines of evidence suggest t...; 关键词：Hematopoietic STEM PROGENITOR cells Tissue specific stem/progenitor cells Mesenchymal STEM CELL STEM CELL homing STEM CELL egress Sphingosine-1-phosphate Sphingosine-1-phosphate GRADIENT Sphingosine-1-phosphate receptors

Role of sphingosine kinase localization in sphingolipid signaling: 《World Journal of Biological Chemistry》2010年第12期362-368,共7页Binks W Wattenberg; Supported by The James Graham Brown Cancer Center and NIH, No. CA111987; The sphingosine kinases, SK1 and SK2, produce the potent signaling lipid sphingosine-1-phosphate (S1P). These enzymes have garnered increasing interest for their roles in tumorigenesis, inflammation, vascular diseases...; 关键词：SPHINGOLIPID LIPID signaling CERAMIDE Sphingosine-1-phosphate SPHINGOSINE

Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis被引量：6: 《World Journal of Biological Chemistry》2010年第10期291-297,共7页Kelley M Argraves Brent A Wilkerson W Scott Argraves; Supported by Grants from the United States Public Health Service/National Institutes of Health, No. HL080404, HL094883 (Argraves KM) and HL061873, HL095067 (Argraves WS);NIH Training Grant to Improve Cardiovascular Therapies HL007260 (Wilkerson BA);American Heart Association 10PRE3910006 (Wilkerson BA); Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive n...; 关键词：Sphingosine-1-phosphate VASCULOGENESIS ANGIOGENESIS G-protein-coupled receptors ENDOTHELIUM

Roles of sphingosine-1-phosphate signaling in angiogenesis被引量：5: 《World Journal of Biological Chemistry》2010年第10期298-306,共9页Yoh Takuwa Yasuo Okamoto Noriko Takuwa Kazuaki Yoshioka; Supported by Grants from the Ministry of Education, Science, Sports and Culture of Japan and the Japan Society for the Promotion of Science;the Practical Application Research program of Japan Science and Technology Agency Innovation plaza Ishi-kawa; Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P1-5. S1P1 and S1P2 were originally identifie...; 关键词：Sphingosine-1-phosphate ANGIOGENESIS Angiogenic therapy Rac Akt Vascular MATURATION Endothelial CELLS Bone-marrow-derived CELLS

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