云南高校图书馆联盟文献共享服务平台- SPHINGOSINE

SPHINGOSINE: 作品数：80被引量：236H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张翼肖琼尹大力徐美林王菁更多>>; 相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>

Sphingolipid metabolism and drug resistance in ovarian cancer被引量：3: 《Cancer Drug Resistance》2018年第3期181-197,共17页Kelly M.Kreitzburg Robert C.A.Mvan Waardenburg Karina J.Yoon; Waardenburg RCAM is supported by DoD OCRP pilot grant W81XWH-15-1-0198;This work was supported by Faculty Development Grant from University of Alabama at Birmingham,Comprehensive Cancer Center(P30 CA013148).; Despite progress in understanding molecular aberrations that contribute to the development and progression of ovarian cancer,virtually all patients succumb to drug resistant disease at relapse.Emerging data implicate ...; 关键词：Ovarian cancer DRUG-RESISTANCE CERAMIDE sphingosine-1-phosphate sphingolipid metabolism

Targeting sphingosine-1-phosphate signaling for cancer therapy被引量：7: 《Science China(Life Sciences)》2017年第6期585-600,共16页Zuoquan Xie Hong Liu Meiyu Geng; financial support from the National Natural Science Foundation of China(91229204);the Major Project of the Chinese National Programs for Fundamental Research and Development(2015CB910304); Sphingosine-1-phosphate(S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival,cell proliferation, cell migration, angiogenesis and many other cellular processes. S1 P ...; 关键词：sphingosine-1-phosphate sphingosine ceramide cancer inflammation immunity

siRNA靶向沉默鞘氨醇激酶-1对前列腺癌PC-3细胞生物学行为的影响: 《现代泌尿外科杂志》2015年第9期663-667,共5页李想时湛马瑞宁孙晓青; 目的探讨siRNA靶向沉默SPHK1基因对前列腺癌PC-3细胞生物学行为的影响。方法使用脂质体介导的方法转染人前列腺细胞株PC-3细胞,通过RT-PCR和Western-blot方法分别检测特异性siRNA对SPHK1基因在mRNA和蛋白水平上的沉默效果,CCK-8法测定...; 关键词：RNA干扰前列腺癌鞘氨醇激酶-1 细胞增殖细胞凋亡 SPHINGOSINE kinase-1

Advances in the management of peritoneal mesothelioma被引量：15: 《World Journal of Gastroenterology》2014年第33期11700-11712,共13页Ali Raza Wei-Ching Huang Kazuaki Takabe; Supported by United States National Institute of Health(to Kazuaki Takabe),No.R01CA160688;Investigator Initiated Research Grant(to Susan G Komen),No.IIR12222224; Malignant peritoneal mesothelioma(PM) is an infrequent disease which has historically been associated with a poor prognosis. Given its long latency period and non-specific symptomatology, a diagnosis of PM can be sugg...; 关键词：Peritoneal mesothelioma MESOTHELIOMA Hyperthermic intraperitoneal chemotherapy Cytore-duction Sphingosine kinase Sphingosine-1-phosphate FTY720

STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer被引量：10: 《World Journal of Gastroenterology》2014年第30期10279-10287,共9页Andrew V Nguyen Yuan-Yuan Wu Elaine Y Lin; Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of ST...; 关键词：Sphingosine-1-phosphate Signal transducer and activator of transcription 3 INTERLEUKIN-6 INFLAMMATION Colorectal cancer TUMORIGENESIS Tumor progression Inflammatory bowel disease

鞘氨醇激酶1和核因子-κBp65在非小细胞肺癌组织中的表达及与预后的关系被引量：1: 《天津医药》2014年第4期305-308,共4页畅昶徐美林王菁; 目的探讨鞘氨醇激酶1(SPHK1)和核因子(NF)-κB在非小细胞肺癌(NSCLC)组织中的表达及其与NSCLC浸润、转移和预后的关系。方法选取93例外科手术切除并经常规组织学检查确诊为NSCLC的标本和癌旁正常的余肺组织,应用免疫组化SP法,一抗分别...; 关键词：癌非小细胞肺免疫组织化学预后鞘氨醇激酶1 非小细胞肺癌 SPHINGOSINE KINASE 1

Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —I: 《Pharmacology & Pharmacy》2013年第8期628-637,共10页Noriyasu Seki Yasuhiro Maeda Hirotoshi Kataoka Kunio Sugahara Kenji Chiba; Infiltration of myelin-specific helper T (Th) cells into the central nervous system (CNS) plays a key role in pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study, we investigated the involve...; 关键词：SPHINGOSINE 1-Phosphosphate RECEPTOR 1 FINGOLIMOD Hydrochloride (FTY720) Experimental Autoimmune ENCEPHALOMYELITIS Th1 CELLS Th17 CELLS

Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —II: 《Pharmacology & Pharmacy》2013年第8期638-646,共9页Noriyasu Seki Hirotoshi Kataoka Kunio Sugahara Atsushi Fukunari Kenji Chiba; Therapeutic administration of fingolimod hydrochloride (FTY720), the functional antagonist at sphingosine 1-phosphate (S1P) receptor 1 (S1P1) shows a marked improving effect on experimental autoimmune encephalomyeliti...; 关键词：SPHINGOSINE 1-Phosphosphate RECEPTOR 1 FINGOLIMOD Hydrochloride (FTY720) Experimental Autoimmune ENCEPHALOMYELITIS Astrocytes PRO-INFLAMMATORY Cytokines

Role of sphingosine kinases and sphingosine 1-phosphate in mediating adipogenesis: 《Journal of Diabetes Mellitus》2013年第2期52-61,共10页Lucy D. Mastrandrea; Recent Background: Development of obesity involves promotion of preadipocyte differrentiation. This study investigated the role that sphingosine kinases (SPHK) and ceramide-derived sphingosine 1-phosphate (S1P) play i...; 关键词：ADIPOCYTE ADIPOGENESIS Obesity SPHINGOSINE KINASE 3T3-L1 Cells SPHINGOSINE 1-Phosphate SPHINGOSINE 1-Phosphate Receptor

Sphk1 Expression and Survival Outcomes in Squamous Cell Carcinoma of the Oral Cavity: 《Journal of Cancer Therapy》2013年第3期704-708,共5页Brianna N. Harris Rizwan Masood Uttam K. Sinha; Sphingosine kinase 1 (SphK1) is an important mediator of apoptosis and the proliferation of cancer cells. It is upregulated in cells showing increasing radioresistance. Here we present the correlation between SphK1 ex...; 关键词：SPHINGOSINE KINASE 1 SQUAMOUS Cell CARCINOMA Radiation SPHINGOLIPIDS ORAL Cavity

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