supported by awards from the EPSRC Centre for Doctoral Training in Regenerative Medicine(EP/L014904/1,to JW);an NHS bursary(to RHB);an EPSRC Healthcare Technologies award(EP/T013885/1,to DMC)。
Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative therapies.Biomaterial therapies show promise as medical materials for neural repair through immunomodulation,struct...
supported by the InnoHK Initiative and the Hong Kong Special Administrative Region Government, China (to SYY)。
Physical exercise is recognized as an effective intervention to improve mood,physical performance,and general well-being.It achieves these benefits through cellular and molecular mechanisms that promote the release of...
supported by the National Natural Science Foundation of China,No.82371444(to YZ);the Natural Science Foundation of Hubei Province,No.2022CFB216(to XC);the Key Research Project of Ministry of Science and Technology of China,No.2022ZD021160(to YZ)。
The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental challenges.In the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an impo...
funded by The Michael J.Fox Foundation for Parkinson’s Research(grant numbers:17244 and 023410);Science Foundation Ireland(grant number:19/FFP/6554)(to ED)。
More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet cl...
Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this condition.Diabetic peripheral neuropathy,a common complication of dia...
supported by the National Natural Science Foundation of China,No.81971177(to YK);the Natural Science Foundation of Beijing,No.7222198(to NH);the Peking University People's Hospital Research and Development Fund,No.RDX2021-01(to YK)。
FK506(Tacrolimus)is a systemic immunosuppressant approved by the U.S.Food and Drug Administration.FK506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways ...
supported by the Key Research Projects of Universities of Henan Province,No.21A320064 (to XS);the National Key Research and Development Program of China,No.2021YFA1201504 (to LZ);the Strategic Priority Research Program of the Chinese Academy of Science,No.XDB36000000 (to CW);the National Natural Science Foundation of China,Nos.31971295,12374406 (both to LZ)。
Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a s...
partly supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(Nos.2022M3I7A3046571 and 2023RS00260876);the Brain Korea 21 Plus Project through the NRF funded by the Ministry of Science,ICT and Future Planning,Samsung Electronics(No.IO201223-08257-01);a Korea University Grant.
Oscillatory neural networks(ONNs)can handle image processing and combinational optimization problems with high biological plausibility.Coupled oscillators in ONNs mimic the neuronal oscillations and communication in t...
supported by the National Natural Science Foundation of China(U21A20393);the 1.3.5 project for disciplines of excellence and the Brain Science project of West China Hospital(ZYGD23032);the postdoctoral research fund of West China Hospital(2024HXBH095);the National Key R&D Program(2021YFC2401204,2022YFC2503805);the NIHR University College London Hospitals Biomedical Research Centre;the UK Department of Health sponsors;support from the Marvin Weil Epilepsy Research Fund;the UK Epilepsy Society;the National Institute of Health Research;the Academy of Medical Sciences.
Background Mesial temporal lobe epilepsy(mTLE)is the most common form of focal epilepsy,often associated with hippocampal sclerosis.Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and ...
Neurosurgical patients,including those with severe traumatic brain injury,spinal cord injury,stroke,or raised intracranial pressure,are at heightened risk for stress ulcers and aspiration pneumonitis,leading to signif...