PARKINSONS_DISEASE

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Clinical,mechanistic,biomarker,and therapeutic advances in GBA1-associated Parkinson’s disease
《Translational Neurodegeneration》2024年第1期356-376,共21页Xuxiang Zhang Heng Wu Beisha Tang Jifeng Guo 
supported by the National Key Plan for Scientific Research and Development of China(2021YFC2501204);the National Key R&D Program of China(2021YFC2502100);the National Natural Science Foundation of China(81873785,82071439,81974202,U20A20355);Technology Major Project of Hunan Provincial Science and Technology Department(2021SK1010);the Innovation-driven Team Project from Central South University(2020CX016);the Innovative Team Program from the Department of Science&Technology of Hunan Province(2019RS1010).
Parkinson’s disease(PD)is the second most common neurodegenerative disease.The development of PD is closely linked to genetic and environmental factors,with GBA1 variants being the most common genetic risk.Mutations ...
关键词：Gaucher’s disease Parkinson’s disease GLUCOCEREBROSIDASE Mechanisms BIOMARKER Therapy 
The microglial P2Y_(6) receptor as a therapeutic target for neurodegenerative diseases
《Translational Neurodegeneration》2024年第1期377-387,共11页Jacob M.Dundee Guy C.Brown 
funded by the Medical Research Council UK(MR/L010593);Alzheimer’s Research UK(Dementia Consortium Grant ARUK-DC2017-4,Network Grant G-102212);the Wellcome Trust(Wellcome Institutional Partnership Award 222062/Z/20/Z).
Neurodegenerative diseases are associated with chronic neuroinflammation in the brain,which can result in microglial phagocytosis of live synapses and neurons that may contribute to cognitive deficits and neuronal los...
关键词：Alzheimer’s disease Parkinson’s disease NEURODEGENERATION NEUROINFLAMMATION P2Y_(6)receptor Drug development MICROGLIA 
Neurodegenerative disorders,metabolic icebergs,and mitohormesis被引量：1
《Translational Neurodegeneration》2024年第1期388-408,共21页Matthew C.L.Phillips Martin Picard 
Neurodegenerative disorders are typically“split”based on their hallmark clinical,anatomical,and pathological features,but they can also be“lumped”by a shared feature of impaired mitochondrial biology.This leads us...
关键词：Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis Huntington’s disease Splitting LUMPING MITOCHONDRIA Mitotypes HORMESIS Mitohormesis 
Hybrid nanostructures for neurodegenerative disease theranostics:the art in the combination of biomembrane and non-biomembrane nanostructures
《Translational Neurodegeneration》2024年第1期462-477,共16页Chao Gao Ran Xiong Zhi-yu Zhang Hua Peng Yuan-kai Gu Wei Xu Wei-ting Yang Yan Liu Jie Gao You Yin 
supported by the Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission(23Y11906600);the Shanghai Natural Science Foundation(22ZR147750);the Innovative Clinical Research Project of Shanghai Changzheng Hospital(2023YJBF-PY13,2020YLCYJ-Y02,2020CZWJFW12);the Doctoral Innovation Fund of Shanghai Changzheng Hospital(BSCX2023-19,BSCX2022-34).
The diagnosis of neurodegenerative diseases(NDDs)remains challenging,and existing therapeutic approaches demonstrate little efficacy.NDD drug delivery can be achieved through the utilization of nanostructures,hence en...
关键词：Neurodegenerative diseases BIOMEMBRANE Hybrid nanostructure Alzheimer’s disease Parkinson’s disease Diagnosis 
Blood-brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy被引量：2
《Translational Neurodegeneration》2024年第1期551-574,共24页Kristina Lau Rebecca Kotzur Franziska Richter 
funded by intramural funds with no role in writing of the manuscript.
There is increasing evidence for blood-brain barrier(BBB)alterations in Parkinson’s disease(PD),the second most common neurodegenerative disorder with rapidly rising prevalence.Altered tight junction and transporter ...
关键词：Neurovascular unit SYNUCLEINOPATHIES Α-SYNUCLEIN 
Ultrasensitive detection of aggregatedα-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease
《Translational Neurodegeneration》2024年第1期603-618,共16页Hengxu Mao Yaoyun Kuang Du Feng Xiang Chen Lin Lu Wencheng Xia Tingting Gan Weimeng Huang Wenyuan Guo Hancun Yi Yirong Yang Zhuohua Wu Wei Dai Hui Sun Jieyuan Wu Rui Zhang Shenqing Zhang Xiuli Lin Yuxuan Yong Xinling Yang Hongyan Li Wenjun Wu Xiaoyun Huang Zhaoxiang Bian Hoi Leong Xavier Wong Xin-Lu Wang Michael Poppell Yi Ren Cong Liu Wen-Quan Zou Shengdi Chen Ping-Yi Xu 
supported by National Natural Science Foundation of China(81870856,81870992,82071416,82071417,82188101,32171236);Central Government Guiding Local Science and Technology Development Projects(ZYYD2022C17);Key Research and Development Program of Guangzhou(2023B03J0631);Municipal University(Faculty)Joint Funding Project(202102010010);Municipal and University(Institute)Jointly Funded Project for Basic and Applied Basic Research(202201020472);Guangdong Basic and Applied Basic Research Foundation(2021B1515140026,2022B1515230004);the Science and Technology Commission of Shanghai Municipality(STCSM)(20XD1425000,2019SHZDZX02 and 22JC1410400).
Background Seed amplification assays(SAA)enable the amplification of pathological misfolded proteins,includ‑ingα-synuclein(αSyn),in both tissue homogenates and body fluids of Parkinson’s disease(PD)patients.SAA inv...
关键词：Α-SYNUCLEIN Seed amplification assay Quiescent SAA Parkinson’s disease Seeding activity 
DOPA-decarboxylase is elevated in CSF,but not plasma,in prodromal and de novo Parkinson’s disease
《Translational Neurodegeneration》2024年第1期692-695,共4页Ellen Appleton Shervin Khosousi Michael Ta Michael Nalls Andrew B.Singleton Andrea Sturchio Ioanna Markaki Wojciech Paslawski Hirotaka Iwaki Per Svenningsson 
supported in part by the Intramural Research Program of the National Institute on Aging(NIA),the Center for Alzheimer’s and Related Dementias(CARD),within the Intramural Research Program of the National Institute on Aging and the National Institute of Neurological Disorders and Stroke(AG000546).
Parkinson’s disease(PD)diagnosis is based solely on clinical presentation[1].Therefore,diagnostic and prog-nostic biomarkers are needed.In recent years,seeding aggregation assays(SAA)have demonstrated the ability to ...
关键词：ELEVATED diagnosis clinical 
Biases inα-synuclein immuno-quantitation:a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
《Translational Neurodegeneration》2024年第1期874-878,共5页Florent Laferrière Ludivine Sabatier Stéphane Claverol Francesca De Giorgi François Ichas 
support from the French Agence Nationale de la Recherche(ANR),under grant ANR-22-CE16-0002(project ASAPS);supported by the Center of Excellence in Neurodegeneration(CoEN)Bordeaux Initiative for Neurodegenerative Disorders(BIND)reference CHUBX 2022/07,by the MSA Coalition Global Seed Grant reference MSAC-2022-12-005(project FibrilloScreen).
Parkinson’s disease(PD)and multiple system atrophy(MSA)are distinct neurodegenerative disorders sharing the accumulation of pathological alpha-synuclein(α-syn)amyloids in neurons or glial cells.Amyloidogenesis arise...
关键词：ATROPHY AMYLOID aggregation 
Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease被引量：1
《Translational Neurodegeneration》2024年第1期963-979,共17页Chen-Pei Lin Irene Frigerio John G.J.M.Bol Maud M.A.Bouwman Alex J.Wesseling Martin J.Dahl Annemieke J.M.Rozemuller Ysbrand D.van der Werf Petra J.W.Pouwels Wilma D.J.van de Berg Laura E.Jonkman 
funded by The Michael J.Fox Foundation(17253).
Background Degeneration of the locus coeruleus(LC)noradrenergic system contributes to clinical symptoms in Alzheimer’s disease(AD)and Parkinson’s disease(PD).Diffusion magnetic resonance imaging(MRI)has the potentia...
关键词：Locus coeruleus Noradrenergic degeneration Alzheimer’s disease Parkinson’s disease Diffusion MRI POST-MORTEM HISTOPATHOLOGY 
Life and disease status of patients with Parkinson’s disease during and after zero-COVID in China:an online survey
《Translational Neurodegeneration》2024年第1期980-990,共11页Pei Huang Yu-Yan Tan Biao Chen Hui-Fang Shang Li-Juan Wang Chun-Feng Liu Ling Chen Ying Chang Han Wang Xue-Lian Wang Xiao-Guang Lei Li-Fen Yao Yang Yu Zheng Ye Hai-Bo Chen Sheng-Di Chen 
supported in part by grants from the National Natural Science Foundation of China(82171401,81971187,81971183,82371414);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05).
Background Little is known about the impact of the COVID-19 pandemic on patients with Parkinson’s disease(PD)at different stages of the pandemic.This study aims to assess the lives and disease status of PD patients d...
关键词：COVID-19 Parkinson’s disease Lockdown INFECTION Zero-COVID 
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