POTENTIAL

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P2X7 receptors and multiple sclerosis: A potential biomarker and therapeutic target?
《Neural Regeneration Research》2026年第1期318-319,共2页Cristina Agliardi Franca Rosa Guerini Mario Clerici 
supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294;supported by#NEXTGENERATIONEU (NGEU);funded by the Ministry of University and Research (MUR);National Recovery and Resilience Plan (NRRP);project MNESYS (PE0000006)–A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)(to FRG);partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG)。
Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It ...
关键词：SCLEROSIS DEGENERATION THERAPEUTIC 
Potential treatment of Alzheimer's disease astrocyte pathology based on nuclear lipid regulation
《Neural Regeneration Research》2026年第1期322-323,共2页Masato Komai Nobumasa Takasugi 
supported by a grant from the Japan Foundation for applied enzymology (to NT);the Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (26430059, 17K08272, and 20K07014 to NT);the establishment of university fellowships toward the creation of science technology innovation (JPMJFS2128);a Grant-in-Aid for JSPS Fellows (23KJ1603)(to MK)。
The purpose of this perspective is to discuss the future development of a potential treatment of glial pathology in Alzheimer's disease(AD) and a new regulatory mechanism, nuclear lipids, which may be involved in the ...
关键词：PATHOLOGY ALZHEIMER 
Many faces of neuronal activity manipulation in Drosophila
《Neural Regeneration Research》2025年第9期2574-2576,共3页Amber Krebs Steffen Kautzmann Christian Klämbt 
Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuron...
关键词：MANIPULATION potential. NEURONAL 
Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets
《Neural Regeneration Research》2025年第9期2594-2595,共2页Carmela Rita Balistreri Roberto Monastero 
supported by grants from the Next Generation EU-MUR D.M.737/2021-Project PSEBPEHRD-CUP B79J21038330001(to CRB)。
With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by ...
关键词：ALZHEIMER CARDIOVASCULAR 
Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain
《Neural Regeneration Research》2025年第9期2682-2696,共15页Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu 
supported by the National Natural Science Foundation of China,Nos.82001178(to LW),81901129(to LH),82001175(to FX);Shanghai Sailing Program,No.20YF1439200(to LW);the Natural Science Foundation of Shanghai,China,No.23ZR1450800(to LH);and the Fundamental Research Funds for the Central Universities,No.YG2023LC15(to ZX)。
Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein ...
关键词：dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons 
Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
《Neural Regeneration Research》2025年第3期805-807,共3页JoséM.Izquierdo 
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds (PID2021-1261520B-100) (MICINN/AEI/FEDER, EU);CBM receives an institutional grant from the Fundación Ramón Areces, Spain。
The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre...
关键词：LATIN POTENTIAL lasting 
Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets
《Neural Regeneration Research》2025年第2期378-393,共16页Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang 
supported by grants from National Key R&D Program of China,No.2023YFC2506100(to JZ);the National Natural Science Foundation of China,No.82171062(to JZ).
Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular degeneration.It causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central ...
关键词：choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition MYOFIBROBLAST neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor 
Krüppel-like factor 2(KLF2),a potential target for neuroregeneration
《Neural Regeneration Research》2024年第11期2327-2328,共2页Surajit Hansda Prateeksha Prateeksha Hiranmoy Das 
supported in part by National Institutes of Health grants,R01AR068279(NIAMS),STTR R42EY031196(NEI),and STTR 1R41AG057242(NIA)(to HD).
Neurological disorders and injuries lead to the impairment or depletion of neurons in terms of quantity,structure,or function,resulting in the loss of cognitive,emotional,and physical abilities in human beings.This,in...
关键词：COMPANIES INJURIES POTENTIAL 
Potential of molecular chaperones for treating Alzheimer’s disease
《Neural Regeneration Research》2024年第11期2343-2344,共2页Gefei Chen Jan Johansson 
supported by grants from the Alzheimer’s Association Research Grant(to GC);Olle Engkvists Stiftelse(to GC);the Petrus and Augusta Hedlunds Stiftelse(to GC);Ake Wibergs stiftelse(to GC);the Swedish Alzheimer foundation(to GC);the Ahlén Stiftelsens(to GC);Karolinska Institutet Research Foundation Grant(to GC);the Stiftelsen for Gamla Tjanarinnor(to GC);the Stiftelsen Sigurd och Elsa Goljes Minne(to GC);the Loo and Hans Osterman Foundation(to GC);Geriatric Diseases Foundation at Karolinska Institutet(to GC);the Gun and Bertil Stohne’s Foundation(to GC);the Magnus Bergvall Foundation(to GC).
Alzheimer’s disease(AD)is the most prevalent form of dementia,i.e.,progressive memory loss and profound cognitive dysfunction,resulting in a considerable societal burden.At the neuropathological level,the brains of A...
关键词：ALZHEIMER INFLAMMATION AΒ 
OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis
《Neural Regeneration Research》2024年第11期2513-2521,共9页Wenzhi Chen Shishi Jiang Shu Li Cheng Li Renshi Xu 
supported by the National Natural Science Foundation of China,Nos.30560042,81160161,81360198,82160255;a grant from Department of Education of Jiangxi Province,Nos.GJJ13198,GJJ170021;Jiangxi Provincial Department of Science and Technology,Nos.[2014]-47,20142BBG70062,20171BAB215022,20192BAB205043;Science and Technology Plan of Jiangxi Commission of Health,Nos.202210002,202310119(all to RX).
Amyotrophic lateral sclerosis is a neurodegenerative disease,and the molecular mechanism underlying its pathology remains poorly understood.However,inflammation is known to play an important role in the development of...
关键词：amyotrophic lateral sclerosis DRIVER NEUROINFLAMMATION OSMR C9ORF72 neurodegenerative disease PATHOGENESIS oxidative stress protein misfolding mitochondrial dysfunction 
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