SPINAL_CORD_INJURY

作品数：865被引量：2691H指数：21
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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury
《Neural Regeneration Research》2026年第1期365-376,共12页Fanzhuo Zeng Yuxin Li Xiaoyu Li Xinyang Gu Yue Cao Shuai Cheng He Tian Rongcheng Mei Xifan Mei 
supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM);the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...
关键词：ANGIOGENESIS apoptosis brain-derived neurotrophic factor colony stimulating factor 1 receptor inflammation MICROGLIA motor function spinal cord injury vascular endothelial growth factor 
Spinal cord injury–associated disruption of the autonomic immune control:Does biological sex matter?
《Neural Regeneration Research》2026年第1期298-299,共2页Sara Rito-Fernandes António J.Salgado Nuno A.Silva Susana Monteiro 
funded by the Santa Casa Neuroscience Awards—Prize Melo e Castro for Spinal Cord Injury Research(MC-18-2021)(to AJS and NAS);by the Wings for Life Spinal Cord Research Foundation(WFL-PT-14/23)(to NAS);funded by national funds through the Foundation for Science and Technology(FCT)—projects UIDB/50026/2020,UIDP/50026/2020,and EXPL/MED-PAT/0931/2021-http://doi.org/10.54499/EXPL/MED PAT/0931/2021;supported by the Norte Portugal Regional Operational Programme(NORTE 2020)under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund(ERDF)(to SM);the support given by the Portuguese Foundation of Science and Technology to SM(CEECIND/01902/2017-Doi:10.54499/CEECIND/01902/2017/CP1458/CT0024),and NAS(CEECIND/04794/2007)。
The impact of spinal cord injury(SCI)on the immune system is increasingly recognized in a field traditionally focused on motor impairments.SCI can seriously affect the immune system by progressively disrupting the reg...
关键词：MORTALITY SPINAL 
Dynamic development of microglia and macrophages after spinal cord injury
《Neural Regeneration Research》2025年第12期3606-3619,共14页Hu-Yao Zhou Xia Wang Yi Li Duan Wang Xuan-Zi Zhou Nong Xiao Guo-Xing Li Gang Li 
Secondary injury following spinal cord injury is primarily characterized by a complex inflammatory response,with resident microglia and infiltrating macrophages playing pivotal roles.While previous studies have groupe...
关键词：acute inflammation bioinformatics analysis FIBROBLAST integrinβ2 ligand-receptor interaction NEUROINFLAMMATION oncostatin M single-cell RNA sequencing spatial transcriptomics spinal cord injury 
Biomaterial-based strategies:a new era in spinal cord injury treatment
《Neural Regeneration Research》2025年第12期3476-3500,共25页Shihong Zhu Sijun Diao Xiaoyin Liu Zhujun Zhang Fujun Liu Wei Chen Xiyue Lu Huiyang Luo Xu Cheng Qiang Liao Zhongyu Li Jing Chen 
supported by the Sichuan Science and Technology Program,No.2023YFS0164(to JC);the National Natural Science Foundation of China,No.82401629(to XL);the Natural Science Foundation of Sichuan Province,No.2024NSFSC1646(to XL);the China Postdoctoral Science Foundation,Nos.GZC20231811(to XL)and 2024T170601(to XL)。
Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention recently.Spinal cord injury is associated with a complex molecular and cellular microenvironment.This co...
关键词：BIOMATERIALS growth factors NANOPARTICLES neural regeneration scaffolds spinal cord injury stem cells therapy strategies tissue engineering 
Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury
《Neural Regeneration Research》2025年第11期3063-3075,共13页Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant 
supported by Ohio State Start Up Fund;National Institutes of Health(NIH);Department of Defense(DoD);Wings for Life Spinal Cord Research Foundation,Wings for Life Spinal Cord Research Foundation(Austria);California Institute of Regenerative Medicine(CIRM);International Spinal Research Trust(United Kingdom);Stanford University Bio-X Program Interdisciplinary Initiatives Seed Grant IIP-7;Dennis Chan Foundation;Klein Family Fund;Lucile Packard Foundation for Children's Health;Stanford Institute for Neuro-Innovation and Translational Neurosciences(SINTN);Saunders Family Neuroscience Fund;James Doty Neurosurgery Fund;Hearst Neuroscience Fund;Eileen Bond Research Fund(to GP)。
In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative medicine.Considering the non-regenerative nature of the mature central nervous system,the c...
关键词：axon regeneration central nervous system regeneration induced pluripotent stem cells NEUROTRAUMA regenerative medicine spinal cord injury stem cell therapy 
Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury
《Neural Regeneration Research》2025年第11期3231-3232,共2页Andreia Monteiro Susana Monteiro Nuno A.Silva 
funded by national funds,through the Foundation for Science and Technology(FCT)-project UIDB/50026/2020,UIDP/50026/2020(to NAS),EXPL/MEDPAT/0931/2021(to SM);Financial support was provided by Prémios Santa Casa Neurociências-Prize Melo e Castro for Spinal Cord Injury Research(MC-18-2021);Wings For Life Spinal Cord Research Foundation(WFL-PT-14/23);"la Caixa"Foundation(HR23-00484)(to NAS);the FCT for the Scientific Employment Stimulus to NAS and SM(CEECIND/04794/2017 and CEECIND/01902/2017)。
Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterat...
关键词：alterations injury COMPANIES 
Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury
《Neural Regeneration Research》2025年第11期3273-3286,共14页Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu 
supported by the National Natural Science Foundation of China,No.81801907(to NC);Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research,No.ZDSYS20230626091402006(to NC);Sanming Project of Medicine in Shenzhen,No.SZSM201911002(to SL);Foundation of Shenzhen Committee for Science and Technology Innovation,Nos.JCYJ20230807110310021(to NC),JCYJ20230807110259002(to JL);Science and Technology Program of Guangzhou,No.2024A04J4716(to TL)。
We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury.While exosomes are recognized as playing a pivotal role in neural stem cells exocrine func...
关键词：cellular communication competing endogenous RNA EXOSOMES Foxp1 NECROPTOSIS neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2 
Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury
《Neural Regeneration Research》2025年第11期3287-3301,共15页Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng 
supported by the National Natural Science Foundation of China,Nos.82071387(to HT),81971172(to YW);the Natural Science Foundation of Zhejiang Province,China,No.LY22H090012(to HT);the Basic Research Project of Wenzhou City,China,No.Y20220923(to MZ)。
The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury.Regulation of shifting microglia ...
关键词：cGAS/STING functional recovery MICROGLIA neuroinflammation neuroprotection nuclear factor-κB POLARIZATION spinal cord injury TRYPTANTHRIN 
The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury
《Neural Regeneration Research》2025年第11期3317-3329,共13页Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda 
supported by COBRE(P30GM149367);the Puerto Rico Science&Technology Trust(2022-00125);MBRS-RISE Program(R25 GM061838);SC1GM144032 program(all to JDM)。
In addition to the loss of motor function,~60% of patients develop pain after spinal cord injury.The cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epice...
关键词：ALLODYNIA central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury TRAUMA 
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury
《Neural Regeneration Research》2025年第10期2955-2968,共14页Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong 
supported by grants from the National Key Research and Development Program of China,No.2017YFA0105400(to LR);the Key Research and Development Program of Guangdong Province,No.2019B020236002(to LR);the National Natural Science Foundation of China,Nos.81972111(to LZ),81772349(to BL).
Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord injury.However,the precise mechanism remains unclear.To investigate the molecular mechanisms by which mi...
关键词：ceramide synthase 5 gasdermin D MICROGLIA NEUROINFLAMMATION NLRP3 nuclear factor kappa B Pla2g7 PYROPTOSIS sphingomyelin metabolism spinal cord injury 
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