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Role of gut microbiota and mesenteric adipose tissue in the pathology of Crohn’s disease:Potential therapeutic targets: 《World Journal of Gastroenterology》2025年第13期1-6,共6页Han-Jung Liu Meng-Che Wu Shuo-Yan Gau; This editorial comments on the article by Wu et al in the World Journal of Gastroenterology.The article explored the relationship between mesenteric adipose tissue,creeping fat,inflammation,and gut microbiota in Crohn...; 关键词：Crohn’s disease Gut microbiota PROBIOTICS Ulcerative colitis Inflammatory bowel disease

Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease:A critical review and the path forward: 《World Journal of Gastrointestinal Endoscopy》2025年第4期74-78,共5页Arunkumar Krishnan; The study by Ohno et al provides valuable insights into the role of leucine-rich alpha-2-glycoprotein(LRG)as a potential biomarker for identifying small bowel lesions in Crohn's disease(CD).However,several methodologi...; 关键词：Crohn's disease Leucine-rich alpha-2 glycoprotein Biomarkers Small bowel lesions Inflammatory bowel disease Disease monitoring Precision medicine

Role of interleukins in the pathogenesis of coronary heart disease:A literature review: 《World Journal of Cardiology》2025年第3期41-57,共17页Saira Rafaqat Azeem Azam Ramsha Hafeez Hamza Faseeh Maria Tariq Muhammad Asif Amber Arshad Iqra Noshair; Interleukins(ILs),a subset of cytokines,play a critical role in the pathogenesis of coronary heart disease(CHD)by mediating inflammation.This review article summarizes the role of ILs such as IL-1,IL-2,IL-3,IL-4,IL-5,...; 关键词：Coronary heart disease INTERLEUKINS Inflammation PATHOGENESIS

Mitochondrial dysfunction in the pathogenesis of acute pancreatitis被引量：1: 《Hepatobiliary & Pancreatic Diseases International》2025年第1期76-83,共8页Xia Chen Rui Zhong Bing Hu; supported by a grant from the Fund of Chengdu Medical College (CYZYB22-03)。; The mechanism of cell damage during acute pancreatitis (AP) has not been fully elucidated, and there is still a lack of specific or effective treatments. Increasing evidence has implicated mitochondrial dysfunction as...; 关键词：Acute pancreatitis AUTOPHAGY Calcium Cell death Inflammation MITOCHONDRIA MITOPHAGY

Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease: 《World Journal of Hepatology》2025年第2期31-46,共16页Li-Hui Zhang Su-Tong Liu Qing Zhao Xiao-Yan Liu Tong Liu Qiang Zhang Ming-Hao Liu Wen-Xia Zhao; Supported by Henan Province's"Double First-Class"Creation of Scientific Research in Traditional Chinese Medicine,No.HSRPDFCTCM-2023-7-23 and No.STG-ZYX02-202117;National Traditional Chinese Medicine Clinical Research Base Scientific Research Special Project,No.2022JDZX098 and No.2022JDZX114;National Natural Science Foundation of China,No.82205086;The 9th China Association for Science and Technology Young Talent Support Project,No.2023QNRC001.; Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellula...; 关键词：Triggering receptor expressed on myeloid cells 2 Non-alcoholic fatty liver disease MACROPHAGE Lipid metabolism Inflammation

Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin: 《World Journal of Gastroenterology》2024年第45期4817-4835,共19页Wen-Zhe Li Yu Xiong Tian-Kun Wang Yan-Yan Chen Song-Lin Wan Lu-Yao Li Meng Xu Jing-Jing Tong Qun Qian Cong-Qing Jiang Wei-Cheng Liu; Supported by the National Natural Science Foundation of China,No.81500505;the Construction of Predominant Disciplines of Zhongnan Hospital of Wuhan University,No.XKJS202017;the Medical Science and Technology Innovation Platform of Joint Foundation of Health Commission of Hubei Province,Zhongnan Hospital of Wuhan University,No.PTXM2021025;the Hubei Provincial Natural Science Foundation,No.2023AFC013.; BACKGROUND Obstructed defecation syndrome(ODS)represents the most prevalent form of chronic constipation,affecting a diverse patient population,leading to numerous complications,and imposing a significant burden on he...; 关键词：Obstructed defecation syndrome DYSTROPHIN Smooth muscle CONTRACTION PROTEOMICS L-type voltage-gated calcium channel

RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model: 《Journal of Genetics and Genomics》2024年第12期1389-1403,共15页Ji-Won Park Tae-Ik Choi Tae-Yoon Kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld Tae Hyeong Kim Florence Petit Yoo-Mi Kim Chong Kun Cheon Yoonsung Lee Cheol-Hee Kim; supported by the National Research Foundation of Korea grant funded by the Korean government(MIST)(2020R1A5A8017671,2022R1A2C100677813,and RS-2024-00349650)。; Williams syndrome(WS)is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular problems.Pre...; 关键词：Williams syndrome RFC2 RFC5 ZEBRAFISH KNOCKOUT CRISPR-Cas9

The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis: 《Cardiology Discovery》2024年第3期231-244,共14页Yuesheng Zhang Ziyin Guan Hui Gong Zhichao Ni Qingzhong Xiao Xiaogang Guo Qingbo Xu; supported by grants from the National Natural Science Foundation of China(82030008,82170489,and U21A20337).; The increasing incidence of arteriosclerosis has become a significant global health burden.Arteriosclerosis is characterized by the thickening and hardening of arterial walls,which can lead to the narrowing or complet...; 关键词：Stem cells Vascular progenitors Endothelial repair Neointimal formation ARTERIOSCLEROSIS

Fecal microbiota and metabolites in the pathogenesis and precision medicine for inflammatory bowel disease: 《Precision Clinical Medicine》2024年第3期235-245,共11页Long Ju Zhimin Suo Jian Lin Zhanju Liu; supported by grants from the National Natural Science Foundation of China(Grant Nos.82370532,82341219);Shanghai Hospital Development Center Foundation(Grant No.SHDC12022118).; Inflammatory bowel disease(IBD)is a chronic inflammatory disorder of the gastrointestinal tract,and its pathogenesis is believed to be associated with an imbalance between commensal organisms and the intestinal immune...; 关键词：inflammatory bowel disease fecal microbiota METABOLITE diagnosis treatment PATHOGENESIS

More than a key—the pathological roles of SARS-CoV-2 spike protein in COVID-19 related cardiac injury: 《Sports Medicine and Health Science》2024年第3期209-220,共12页Zhiqiang Lin; supported by NHLBI(Grant number:R01HL146810).; Cardiac injury is common in hospitalized coronavirus disease 2019(COVID-19)patients and cardiac abnormalities have been observed in a signiﬁcant number of recovered COVID-19 patients,portending long-term health issues...; 关键词：COVID-19 Spike protein Cardiovascular disease Immune responses

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