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The role of axon guidance molecules in the pathogenesis of epilepsy: 《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang; supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。; Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...; 关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease: 《Neural Regeneration Research》2025年第5期1309-1323,共15页Yunfan Long Jiajia Liu Yu Wang Haidong Guo Guohong Cui; supported by the National Natural Science Foundation of China,No.81970991(to GC);Program of Shanghai Academic Research Leader,No.22XD1423400(to HG)。; Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral abnormalities.Neuroinflammatory plaques formed through the extracellular deposition of amyloid-βproteins,as we...; 关键词：Alzheimer's disease amyloid-β glial cells MICRORNAS MIR-146A neuroinflammatory

Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications: 《Acta Pharmaceutica Sinica B》2025年第1期15-34,共20页Umesh Chandra Dash Nitish Kumar Bhol Sandeep Kumar Swain Rashmi Rekha Samal Prabhat Kumar Nayak Vishakha Raina Sandeep Kumar Panda Rout George Kerry Asim K.Duttaroy Atala Bihari Jena; Neuroprotection is a proactive approach to safeguarding the nervous system,including the brain,spinal cord,and peripheral nerves,by preventing or limiting damage to nerve cells and other components.It primarily defend...; 关键词：NEURODEGENERATION Oxidative stress ROS NEUROPROTECTION Mitochondrial dysfunction Aging

YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer’s disease: 《Acta Pharmaceutica Sinica B》2025年第1期331-348,共18页Jinfeng Sun Fan Chen Lingyu She Yuqing Zeng Hao Tang Bozhi Ye Wenhua Zheng Li Xiong Liwei Li Luyao Li Qin Yu Linjie Chen Wei Wang Guang Liang Xia Zhao; supported by the National Natural Science Foundation of China(21961142009 to Guang Liang and 82360805 to Jinfeng Sun);Zhejiang Provincial Key Scientific Project(2021C03041 to Guang Liang);Natural Science Foundation of Zhejiang province(LQ23H090018 to Xia Zhao);Medical and health Science and Technology Project of Zhejiang Province(2024KY055 to Xia Zhao).; Alzheimer’s disease(AD)is the major form of dementia in the elderly and is closely related to the toxic effects of microglia sustained activation.In AD,sustained microglial activation triggers impaired synaptic pruni...; 关键词：Alzheimer's disease YOD1 Myosin heavy chain 9 MICROGLIA Inflammation Cognitivedysfunction

Rebuilding insight into the pathophysiology of Alzheimer’s disease through new blood-brain barrier models被引量：2: 《Neural Regeneration Research》2024年第9期1954-1960,共7页Kinya Matsuo Hideaki Nshihara; supported by the Uehara Memorial Foundation,JSPS under the Joint Research Program implemented in association with SNSF(JRPs),Grant No.JPJSJRP20221507 and KAKENHI Grant No.22K15711,JST FOREST Program(Grant No.JPMJFR2269,Japan);2022 iPS Academia Japan Grant,Life Science Foundation of Japan,Kato Memorial Bioscience Foundation,THE YUKIHIKO MIYATA MEMORIAL TRUST FOR ALS RESEARCH,the ICHIRO KANEHARA FOUNDATION,Takeda Science Foundation,and the YAMAGUCHI UNIVERSITY FUNDATION(all to HN).; The blood-brain barrier is a unique function of the microvasculature in the brain parenchyma that maintains homeostasis in the central nervous system.Blood-brain barrier breakdown is a common pathology in various neur...; 关键词：Alzheimer’s disease blood-brain barrier human induced pluripotent stem cells

The pathogenesis of Parkinson’s disease and crosstalk with other diseases被引量：1: 《BIOCELL》2024年第8期1155-1179,共25页TINGTING LIU DINGYOU GUO JIANSHE WEI; supported partly by the National Natural Science Foundation of China(32161143021,81271410);Henan University Graduate《Talent Program》of Henan Province(SYLYC2023092);Henan Natural Science Foundation of China(182300410313).; In China,Parkinson’s disease(PD)is the second most prevalent central nervous system(CNS)degenerative illness affecting middle-aged and older persons.Movement disorders including resting tremor,bradykinesia,myotonia,p...; 关键词：Parkinson’s disease Mitochondrial dysfunction Oxidative stress Inflammation Cancer THERAPIES

Tau truncation in the pathogenesis of Alzheimer's disease:a narrative review被引量：4: 《Neural Regeneration Research》2024年第6期1221-1232,共12页Dandan Chu Xingyue Yang Jing Wang Yan Zhou Jin-Hua Gu Jin Miao Feng Wu Fei Liu; supported by the Neural Regeneration Co-innovation Center of Jiangsu Province,Nantong University(to DC);the National Natural Science Foundation of China,Nos.81872853(to DC),81870941(to JHG);the Science and Technology Project of Nantong City,Nos.JC22022022(to FW)and JC2021059(to JM)。; Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein...; 关键词：Alzheimer's disease cleavage site diagnosis MARKER neurofibrillary tangles PHOSPHORYLATION TAU Tau aggregation therapy TRUNCATION

Implications of MMP-12 in the pathophysiology of ischaemic stroke被引量：1: 《Stroke & Vascular Neurology》2024年第2期97-107,共11页Krishna Kumar Veeravalli; The National Institute of Neurological Disorders and Stroke of the National Institutes of Health awarded a research grant(Award Number:R01NS102573)to study the role of MMP-12 in ischaemic stroke.; This article focuses on the emerging role of matrix metalloproteinase-12(MMP-12)in ischaemic stroke(IS).MMP-12 expression in the brain increases dramatically in animal models of IS,and its suppression reduces brain da...; 关键词：INVOLVEMENT ALONE DIRECTIONS

Mitochondrial Calcium Homeostasis in the Pathology and Therapeutic Application in Friedreich's Ataxia被引量：1: 《Neuroscience Bulletin》2023年第4期695-698,共4页Hongting Zhao Zhuoyuan Li Yutong Liu Meng Zhang Kuanyu Li; supported by the National Natural Science Foundation of China(31871201 and 31371060).; Friedreich's ataxia(FRDA)is the most common neurodegenerative disease caused by an autosomal recessive singlegene mutation,affecting 2-4 per 100,000 Caucasians[1].The causative gene is frataxin(FXN),located on chromos...; 关键词：Friedreich THERAPEUTIC STASIS

Update on the pathological roles of prostaglandin E_(2) in neurodegeneration in amyotrophic lateral sclerosis: 《Translational Neurodegeneration》2023年第1期464-478,共15页Hiroshi Nango Komugi Tsuruta Hiroko Miyagishi Yuri Aono Tadashi Saigusa Yasuhiro Kosuge; funded in part by a Nihon University Research Grant for 2022-2023(to YK,HM,YA,and TS);JSPS KAKENHI(22K06654 to YK and TS,and 21K06620 to HM and YK).; Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons.The pathogenesis of ALS remains largely unknown;however,inflammatio...; 关键词：Prostaglandin E_(2) Amyotrophic lateral sclerosis Motor neuron death E-prostanoid receptor Microsomal prostaglandin E synthetase-1

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