ACUTE_LUNG_INJURY

作品数：290被引量：1544H指数：19
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相关作者：李晓锋王强李中军高小力孟祥豹更多>>
相关机构：北京协和医学院东南大学复旦大学四川大学华西医院更多>>
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Regulation of lncRNA-ENST on Myc-mediated mitochondrial apoptosis in mesenchymal stem cells:In vitro evidence implicated for acute lung injury therapeutic potential
《World Journal of Stem Cells》2025年第3期65-80,共16页Ye-Zhou Shen Guang-Ping Yang Qi-Min Ma Yu-Song Wang Xin Wang 
Supported by the Peak Supporting Clinical Discipline of Shanghai Health Bureau,No.2023ZDFC0104;the National Key R&D Program of China,No.2019YFA0110601.
BACKGROUND Acute lung injury(ALI)is a fatal and heterogeneous disease.While bone marrow mesenchymal stem cells(BMSCs)have shown promise in ALI repair,their efficacy is compromised by a high apoptotic percentage.Prelim...
关键词：Long noncoding RNA Mesenchymal stem cell MITOCHONDRIAL Apoptosis AUTOPHAGY Acute lung injury 
Association of interleukin-6 with acute lung injury risk and disease severity in sepsis
《World Journal of Clinical Cases》2025年第8期49-52,共4页Imshaal Musharaf Abdulqadir J Nashwan 
Sepsis is a life-threatening condition caused by a dysregulated response of the body in response to an infection that harms its tissues and organs.Interleukin-6(IL-6)is a significant component of the inflammatory resp...
关键词：SEPSIS Acute lung injury Multiple organ dysfunction syndrome INTERLEUKIN-6 BIOMARKER Critical illness 
Germacrone ameliorates acute lung injury induced by intestinal ischemia-reperfusion by regulating macrophage M1 polarization and mitochondrial defects
《Acta Biochimica et Biophysica Sinica》2025年第2期261-273,共13页Yunguang Wang Xinxin He Hua Zhang Wei Hu 
supported by the grants from the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.LHDMY24H270002);the Zhejiang Provincial Medical and Health Technology Project(No.2023KY158);the Cultivation Program for Excellent Young Talents of Hangzhou First People’s Hospital(No.YQNYC202131);the Hangzhou Health Science and Technology Plan-Major Project(No.Z20220026).
Intestinal ischemia-reperfusion(I/R)injury severely affects the lungs.Germacrone(Ger)possesses anti-inflammatory and antioxidant properties.However,it is unclear whether it protects the lungs from I/R injury.In this s...
关键词：lung injury GERMACRONE macrophage polarization mitochondrial function intestinal ischemia-reperfusion 
NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS
《Chinese Chemical Letters》2025年第2期309-315,共7页Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu 
financially supported by the Key Research&Development Program of Guangxi(No.GuiKeAB22080088);the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(No.2023GXNSFDA026023);the Natural Science Foundation of Guangxi(No.2023JJA140322);the National Natural Science Foundation of China(No.82360372);the High-level Medical Expert Training Program of Guangxi“139 Plan Funding(No.G202003010);the Medical Appropriate Technology Development and Popularization and Application Project of Guangxi(No.S2020099)。
Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herei...
关键词：Acute lung injury NIR driven Nanozyme ROS scavenging M2 directional polarization 
Discovery of a novel AhReCYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay
《Acta Pharmaceutica Sinica B》2025年第1期508-525,共18页Feng Zhang Bei Zhao Yufan Fan Lanhui Qin Jinhui Shi Lin Chen Leizhi Xu Xudong Jin Mengru Sun Hongping Deng Hairong Zeng Zhangping Xiao Xin Yang Guangbo Ge 
supported by National Natural Science Foundation of China(Nos.U23A20516,81922070,82273897 and 52303191);National Key Research and Development Program of China(No.2022YFC3502000);Shanghai Science and Technology Innovation Action Plans(21S21900600,China);the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02,China);Shanghai Municipal Health Commission’s TCM research project(No.2022CX005,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004,China);the State Key Laboratory of Fine Chemicals,Dalian University of Technology(No.KF 2202,China);Shanghai University of Traditional Chinese Medicine(No.2021LK023,China).
The aryl hydrocarbon receptor(AhR)plays a crucial role in regulating many physiological processes.Activating the AhReCYP1A1 axis has emerged as a novel therapeutic strategy against various inflammatory diseases.Here,a...
关键词：Aryl hydrocarbonreceptor(AhR) Cytochrome P4501A1(CYP1A1) In situ functional imaging Ulcerative colitis(UC) Acute lung injury(ALI) Long term imaging Rational design Inflammatory diseases 
Parkin deficiency aggravates inflammation-induced acute lung injury by promoting necroptosis in alveolar type Ⅱ cells
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期265-278,共14页Meiyu Quan Qiang Guo Xihua Yan Chenhua Yu Linglong Yang Yuting Zhang Jiaqi Li Qiongxia Weng Bin Liu Quan Li Li Dong Junjie Chen Zhenkun Lou Xuru Jin Chengshui Chen Jin-San Zhang 
supported by the National Natural Science Foundation of China(Nos.82370085 and 82170017 to CC);funding from the Zhejiang Province Public Welfare Fund Project(No.LY24H050003);the Discipline Cluster of Oncology at Wenzhou Medical University,China(No.Z1-2023004);startup research funds from both the Quzhou Affiliated Hospital and The First Affiliated Hospital of Wenzhou Medical University。
Background: Necroptosis is a form of programmed cell death resulting in tissue inflammation due to the release of intracellular contents. Its role and regulatory mechanism in the context of acute lung injury (ALI) are...
关键词：Acute lung injury PARKIN NECROPTOSIS Alveolar type 2(AT2)cells INFLAMMATION Fibrosis Transgenic mouse models 
Protective Effect of Shenfu Injection against Sepsis-induced Acute Lung Injury by Suppressing Inflammation and Apoptosis Through the Regulation of the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway
《World Journal of Traditional Chinese Medicine》2024年第4期528-534,共7页Li-Juan Cao Hai-Tang Xie Zhong-Xia Chu Yue Ma Ming-Ming Wang Shi Zhuang 
supported by the Inner Mongolia University for the Nationalities General Project (NMDYB17171)
Objective:Sepsis-induced acute lung injury(ALI) is a clinically critical condition with a high mortality rate.Shenfu injection(SFI) is a Chinese herbal medicine extracted from red ginseng and Aconite,Radix Aconiti,wit...
关键词：Acute lung injury APOPTOSIS INFLAMMATION Janus kinase 2/signal transducer and activator of transcription 3 pathway Shenfu injection 
Exploring the bioactive substances and mechanisms of Chuanxiong Rhizoma treating acute lung injury based on combined network pharmacological,phytochemical,and pharmacological investigations
《Guideline and Standard in Chinese Medicine》2024年第4期182-194,共13页Lintao Xu Xinping Cheng Qingwen Hu Guangcheng Peng Xinyu Qi Yu Zhao Xiaoning Wang Zhenpeng Xu Tao Shen 
supported by NNSF of China(81673558 and 81874341);Shandong Provincial Natural Science Foundation(ZR2023LZY003);Multidisciplinary Research and Innovation Program of Shandong University(No.2020QNQT007);Outstanding Young Scholars Program of Shandong University.
Background:Acute lung injury(ALI)is a high-fatality respiratory disease,and the development of new therapeutic agents is ongoing.Chuanxiong Rhizoma has been prescribed for the therapy of ALI in traditional Chinese med...
关键词：Chuanxiong Rhizoma acute lung injury network pharmacology PHTHALIDE inflammation 
Medical ozone alleviates acute lung injury by enhancing phagocytosis targeting NETs via AMPK/SR-A1 axis被引量：1
《Journal of Biomedical Research》2024年第6期569-584,共16页Chenxiao Yan Yong Zhang Lai Jin Xiaojie Liu Xuexian Zhu Qifeng Li Yu Wang Liang Hu Xueming He Hongguang Bao Xia Zhu Qian Wang Wen-Tao Liu 
supported by the National Natural Science Foundation of China(Grant Nos.82271252,82204542,and 81971047);the Lianyungang Science and Technology Program Project(Grant Nos.SF2122 and SF2214);the Scientific Research Project of Jiangsu Provincial Health Commission(Grant No.Z2021066);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.21KJB310019);the Open Project of Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University(Grant No.XZSYSKF2021014).
Acute lung injury(ALI)linked to sepsis has a high mortality rate,with limited treatment options available.In recent studies,medical ozone has shown the potential to alleviate inflammation and infection.Here,we aimed t...
关键词：SR-A1 NETS ALI PHAGOCYTOSIS ozone therapy 
Targeting TLR4 and regulating the Keap1/Nrf2 pathway with andrographolide to suppress inflammation and ferroptosis in LPS-induced acute lung injury
《Chinese Journal of Natural Medicines》2024年第10期914-928,共15页LI Yichen HUANG Liting LI Jilang LI Siyuan LV Jianzhen ZHONG Guoyue GAO Ming YANG Shilin HAN Shan HAO Wenhui 
supported by China-ASEAN International Innovative Center for Health Industry of Traditional Chinese Medicine(No.AD20297142);Guangxi Collaborative Innovation Center for Scientific Achievements Transformation and Applicationon Traditional Chinese Medicine(No.05020058)。
Acute lung injury(ALI)is a severe inflammatory condition with a high mortality rate,often precipitated by sepsis.The pathophysiology of ALI involves complex mechanisms,including inflammation,oxidative stress,and ferro...
关键词：ANDROGRAPHOLIDE Acute lung injury Ferroptosis Toll-like receptor 4 Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2 
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