ANIMAL_MODEL

作品数：812被引量：2531H指数：19
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Exploring the material basis and mechanism of Moringa oleifera in alleviating slow transit constipation based on network pharmacology and animal models
《Food Science and Human Wellness》2025年第3期902-913,共12页Sijin Li Xiaoyu Gao Kaifeng Guo Shuangfeng Liu Weiqian Yang Yan Zhao Jun Sheng Zhongbin Bai Yang Tian 
Moringa oleifera have laxative effects,but their active compositions and mechanisms are not very clear thus far.To this end,we systematically explored the active components and mechanism of M.oleifera leaves in reliev...
关键词：Moringa oleifera Network pharmacology L-PHENYLALANINE Gastrointestinal motility LAXATIVE 
Animal models of human herpesvirus infection
《Animal Models and Experimental Medicine》2025年第4期615-628,共14页Ziqing Jia Dong Zhang Lin Zhu Jing Xue 
National Natural Science Foundation of China,Grant/Award Number:82222041 and 82241068;CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-037 and 2023-I2M-2-001;National Key Research and Development Project of China,Grant/Award Number:2023YFC2309000;Beijing Natural Science Foundation,Grant/Award Number:Z220018。
Human herpesvirus,a specific group within the herpesvirus family,is responsible for a variety of human diseases.These viruses can infect humans and other vertebrates,primarily targeting the skin,mucous membranes,and n...
关键词：animal models EBV HSV human herpesvirus KSHV VZV 
The protective effects of melatonin against electromagnetic waves of cell phones in animal models:A systematic review
《Animal Models and Experimental Medicine》2025年第4期629-637,共9页Mohammad Amiri Habibolah Khazaie Masoud Mohammadi 
Deputy for Research and Technology,Kermanshah University of Medical Sciences,Grant/Award Number:4030031。
Background:Due to the widespread use of cell phone devices today,numerous re-search studies have focused on the adverse effects of electromagnetic radiation on human neuropsychological and reproductive systems.In most...
关键词：animal model cell phone radiation MELATONIN 
Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma
《Animal Models and Experimental Medicine》2025年第4期696-706,共11页Bing Zhang Tingting Fu Yi Han Gongke Li Xianyao Wan Yong Li 
This study was supported by Development Project of Key Laboratory of Big Data Analysis and Knowledge Service of Science and Technology Innovation Platform of Yangzhou-Yangzhou University Cooperation,Grant/Award Number:YBK202204;Jiangsu Province 333 High-level Talent.Training Project,Grant/Award Number:BRA2020176。
Backgroud:Thoracic Trauma and Limb Fractures Are the Two most Common Injuries in Multiple Trauma.However,there Is Still a Lack of Mouse Models of Trauma Combining Tibial Shaft Fracture(TSF)and Thoracic Trauma.In this ...
关键词：animal model CYTOKINES MICROIMAGING multiple trauma pulmonary contusion 
Comparison of the pathogenicity and neutrophil and monocyte response between SARS-CoV-2 prototype and Omicron BA.1 in a lethal mouse model
《Animal Models and Experimental Medicine》2025年第4期707-717,共11页Na Rong Jing Wu Binbin Zhao Wanjun Peng Hekai Yang Gengxin Zhang Dangting Ruan Xiaohui Wei Jiangning Liu 
supported by Beijing Natural Science Foundation(Grant No.Z210014);National Natural Science Foundation of China(Grant No.32070543);National Key Research and Development Project of China(Grant No.2022YFC2303404);CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2022-12M-CoV19-002)
Background:SARS-CoV-2,first identified in late 2019,has given rise to numerous variants of concern(VOCs),posing a significant threat to human health.The emer-gence of Omicron BA.1.1 towards the end of 2021 led to a pa...
关键词：animal model SARS-CoV-2 Omicron BA.1 MONOCYTE NEUTROPHIL 
Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration被引量：1
《Neural Regeneration Research》2025年第4期1069-1076,共8页Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu Zeng 
supported by a Presidential Postdoctoral Fellowship (021229-00001) from Nanyang Technological University,Singapore (to JZ);a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship (021207-00001) from NTU Singapore;a Mistletoe Research Fellowship (022522-00001) from the Momental Foundaton,USA (to CHL)
The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 d...
关键词：Alzheimer’s disease inflammatory cytokines insulin resistance LIPID 
Glaucoma animal models in rabbits:State of the art and perspectives-A review
《Animal Models and Experimental Medicine》2025年第3期429-440,共12页Rong Hu Kai Wu Jian Shi Juan Yu Xiao-lei Yao 
The 64th batch of China Postdoctoral Science Foundation,Grant/Award Number:2018M640754;National Natural Science Foundation of China,Grant/Award Number:81860870;The“Wang Heng xin Scientific Research Fund”project of Hunan University of Chinese Medicine,Grant/Award Number:2023HX007。
Glaucoma,a visual thief,is characterized by elevated intraocular pressure(IOP)and the loss of retinal ganglion cells(RGCs).Selecting suitable animals for preclinical models is of great significance in research on the ...
关键词：aqueous humor outflow GLAUCOMA intraocular pressure rabbit eye anatomy retinal ischemia-reperfusion 
A murine model of aortic regurgitation generated by transapical wire destruction of the aortic valve
《Animal Models and Experimental Medicine》2025年第3期493-500,共8页Xiaoxia Huang Qiancheng Wang Dan Han Hairuo Lin Zhihong Li Cankun Zheng Jianping Bin Wangjun Liao Zhanchun Cong Mengjia Shen Yulin Liao 
Natural Science Foundation of Guangdong Province,Grant/Award Number:2023A1515110032 and 2022A1515220152;Guangzhou Key Research and Development Program Foundation,Grant/Award Number:202206010199;National Natural Science Foundation of China,Grant/Award Number:82100407,82272602 and 82370242。
Background:The mechanisms underlying cardiac remodeling in aortic valvular(AoV)disease remain poorly understood,partially due to the insufficiency of appropriate preclinical animal models.Here,we present a novel murin...
关键词：animal model aortic regurgitation eccentric hypertrophy heart failure volume overload 
Development of an atherosclerosis rabbit model to evaluate the hemodynamic impact of extracorporeal circulation
《Animal Models and Experimental Medicine》2025年第3期523-533,共11页Anna Kathrin Assmann Jan Buschmann Sinje Reimers Aleyna Karakas Elvira Weber Hug Aubin Artur Lichtenberg Alexander Assmann 
German Heart Foundation/German Foundation of Heart Research。
Background:Aortic atherosclerosis increases the risk of embolic events under extracorporeal circulation(ECC).To evaluate the hemodynamic impact of ECC on atheromatous plaques,an atherosclerosis animal model,which is a...
关键词：animal model ATHEROSCLEROSIS CALCIFICATION extracorporeal circulation INFLAMMATION PLAQUES 
Development of a porcine model of skin and soft-tissue infection caused by Staphylococcus aureus,including methicillin-resistant strains suitable for testing topical antimicrobial agents
《Animal Models and Experimental Medicine》2025年第3期544-557,共14页Filip Raška Břetislav Lipový Šárka Kobzová LukášVacek Rea Jarošová Dominika Kleknerová Katarína Matiašková Peter Makovický Monika Vícenová Edita Jeklová Roman Pantůček Martin Faldyna Lubomír Janda 
Supported by the Ministry of Health of the Czech Republic,Grant/Award Number:NU22-05-00475 and NV19-05-00214。
Background:In view of the ever-increasing representation of Staphylococcus spp.strains resistant to various antibiotics,the development of in vivo models for evaluation of novel antimicrobials is of utmost importance....
关键词：animal model antimicrobial agents porcine model skin and soft-tissue infection(SSTI) Staphylococcus aureus wound infection 
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