CANCER_CELL

作品数：220被引量：561H指数：13
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相关作者：郭鹏曾津芮红兵陈元仲陈炜更多>>
相关机构：西安交通大学医学院第一附属医院北京大学西安交通大学福建医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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Synergistic anti-tumor therapy by a homotypic cell membranecloaked biomimetic nanocarrier with exceptionally potent activity against hepatic carcinoma被引量：3
《Nano Research》2022年第9期8255-8269,共15页Shini Feng Pinyue Ni Yan Gong Bijiang Geng Hui Li Chenlin Miao Ruyu Fan Levon Galstyan Dengyu Pan Fuxue Chen Huafei Li 
“One Belt One Road”International Cooperation Project of Shanghai Municipal Committee of Science and Technology(No.19410740900);the National Natural Science Foundation of China(No.52002239);the International Science and Technology Cooperation Programme of Ministry of Science and Technology of China(No.2019YFE0116800);Natural Science Foundation of Shanghai(No.21ZR1422800).
Hepatic carcinoma(HC)is the sixth most frequently occurring malignancies and the third leading cause of cancer death worldwide.Sepantronium bromide(YM155)is a small molecule inhibitor of survivin,which has broad-spect...
关键词：hepatic carcinoma sepantronium bromide(YM155) cancer cell membrane biomimetic drug delivery system graphene quantum dots photothermal effect 
Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma被引量：5
《Acta Biochimica et Biophysica Sinica》2019年第3期263-276,共14页Xuemei Tao Qiaozhu Zuo Haoyu Ruan Hui Wang Haojie Jin Zhuoan Cheng Yuanyuan Lv Wenxin Qin Cun Wang 
the grants from the National Key Basic Research Program of China(No.2015CB553905);the National Natural Science Foundation of China(Nos.81201626,81402278,81421001,81572311,81672933,and 81772461);the National Key Sci-Tech Special Projects of Infectious Diseases(No.2018ZX10732202-002-003);the Project of Renji Hospital(No.PYXJS16-004);Shanghai Jiao Tong University School of Medicine(No.YG2014MS44);and Shanghai Municipal Commission of Health and Family Planning(No.201640007).
Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma(HCC).The molecular mechanism underlying HCC metastasis remains unclear.In this study,we found that argininosuccinate synt...
关键词：ASS1 HEPATOCELLULAR carcinoma prognosis METASTASIS 
A pH-Activatable Fluorescent Aptamer Probe for Imaging of Target Cancer Cells
《Wuhan University Journal of Natural Sciences》2017年第3期247-251,共5页ZHOU Yan FU Boshi XIAO Heng 
Supported by the National Program on Key Basic Research Project(973 Program)(2012CB720600,2012CB720603,2012CB720605);the National Natural Science Foundation of China(21432008,91413109,81373256,91213302)
Early cancer diagnosis in molecular level shows great promise in relevant prevention and clinical treatment. Herein, we developed a novel method to detect and evaluate biomarkers on cancer cell surface. Based on the e...
关键词：aptamer fluorescence pH-activatable probe cancer cell imaging 
Loading-free supramolecular organic framework drug delivery systems(sof-DDSs) for doxorubicin:normal plasm and multidrug resistant cancer cell-adaptive delivery and release被引量：6
《Chinese Chemical Letters》2017年第4期893-899,共7页Chi Yao Jia Tian Hui Wang Dan-Wei Zhang Yi Liu Fan Zhang Zhan-Ting Li 
the National Natural Science Foundation of China (Nos.21432004,21529201,91527301);the Ministry of Science and Technology of China(No.2013CB834501);the Ministry of Education of China Research Fund for the Doctoral Program and of China for financial support;support from the Molecular Foundry,Lawrence Berkeley National Laboratory,supported by the Office of Science,Office of Basic Energy Sciences,Scientific User Facilities Division,of the U.S.Department of Energy under Contract No.DE-AC0205CH11231
Four water-soluble porous supramolecular organic framework drug delivery systems（sof-DDSs） have been used to adsorb doxorubicin（DOX） in water at physiological pH of 7.4,which is driven exclusively by hydrophobicit...
关键词：Supramolecular organic framework Doxorubicin Drug delivery In situ preparation Hydrophobicity Human breast cancer Controlled release 
Cancer Cell：我国科学家有望开发出治疗急性髓性白血病的新疗法
《现代生物医学进展》2017年第6期I0001-I0002,共2页Chen, Wen-Lian Wang, Yue-Ying Zhao, Aihua Xia, Li Xie, Guoxiang Su, Mingming Zhao, Linjing Liu, Jiajian Qu, Chun Wei, Runmin Rajani, Cynthia Ni, Yan Cheng, Zhen Chen, Zhu Chen, Sai-Juan Jia, Wei 
近日，刊登在国际杂志Cancer Cell上的一项研究报告中，来自上海交通大学医学院等机构的研究人员通过研究发现了治疗急性髓性白血病（AML）的新型治疗靶点和新型疗法，急性髓性白血病是一种血液骨髓癌症，通常需要及时且积极的疗法对这...
关键词：CELL 白血病 治疗 疗法 急性 科学家 开发 上海交通大学 
Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation被引量：7
《Signal Transduction and Targeted Therapy》2017年第1期266-273,共8页Xun Hu Ming Chao Hao Wu 
This work has been supported in part by the China National 973 project(2013CB911303);China Natural Sciences Foundation projects(81470126);the Fundamental Research Funds for the Central Universities,National Ministry of Education,China,to X.H.
Targeting common weaknesses of cancer is an important strategy for cancer therapy.Glucose is a nutrient that maintains essential cellular metabolism,supporting cancer cell survival,growth and proliferation.Depriving g...
关键词：METABOLISM CLINICAL exceptional 
Fabrication of ultrathin Zn（OH）2 nanosheets as drug carriers被引量：1
《Nano Research》2016年第8期2520-2530,共11页Ren Cai Dan Yang Jin Wu Liqin Zhang Cuichen Wu Xigao Chen Yanyue Wang Shuo Wan Fengwei HOU Qingyu Yan Weihong Tan 
The authors are grateful to Dr. Kathryn Williams for her critical comments during the preparation of this manuscript. This work is supported by grants awarded by the National Institutes of Health （No. GM079359 and CA133086）. This work is also supported by the National Basic Research Program of China （No. 2011CB911000）, National Natural Science Foundation of China （Nos. 21221003 and 21327009） and China National Instrumentation Program （No. 2011YQ03012412）.
Ultrathin two-dimensional （2D） porous Zn（OH）2 nanosheets （PNs） were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4-10 nm. To f...
关键词：APTAMER porous Zn（OH）2 nanosheets cancer cell cell-targeted delivery 
Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures被引量：4
《Nano Research》2016年第1期139-148,共10页Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen 
This work was partially supported by the National Natural Science Foundation of China （Nos. 51222203 and 51132006）, the National Basic Research Program of China （Nos. 2011CB911002 and 2012CB932601）, a Jiangsu Natural Science Fund for Distinguished Young Scholars, the Macao Science and Technology Develop- ment Fund （No. 062/2013/A2） and the Research Fund of the University of Macao （Nos. MYRG2014-00033- ICMS-QRCM and MRGOO4/CMW/2014/ICMS）.
Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a compl...
关键词：near-infrared（NIR）-activable drug delivery APTAMER gold nanorods single-walled carbonnanotubes 
Enhanced in vitro anticancer activity of quercetin mediated by functionalized CdTe QDs被引量：2
《Science China Chemistry》2014年第11期1579-1588,共10页WU ChunHui SHI LiXin WU ChangYu GUO DaDong SELKE Matthias WANG XueMei 
supported by the National Basic Research Program of China(2010CB732404);the National Natural Science Foundation of China(21175020);the Project of the Ministry of the Science & Technology of China(2007AA022007);the Natural Science Foundation of Jiangsu Province(BK2008149);the support of National Natural Science Foundation of China(81101147);the China Postdoctoral Science Foundation(2011M501297);the China Postdoctoral Science Special Foundation(2012T50773);the Fundamental Research Funds for the Central Universities(ZYGX2011J099);the support by the State Key Laboratory of Bioelectronics,Southeast University,Nanjing 210096,China(2011E09);the Research Start-up Grants for New Science Faculty of University of Electronic Science and Technology of China(Y02002010901035);support from the United States NSF-CREST program(HRD0932421)
We report in this study the effects of red-emitting CdTe QDs capped with cysteamine(Cys-CdTe) on the in vitro anticancer activity of the well-known flavenoid quercetin(Qu). Various techniques, including the methylthia...
关键词：quantum dots QUERCETIN NANOCOMPOSITES cancer cell inhibition 
One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip被引量：5
《Nano-Micro Letters》2013年第3期213-222,共10页Chenchen Bao Lei Chen Tao Wang Chong Lei Furong Tian Daxiang Cui Yong Zhou 
supported by National Key Basic Research Program (973 Project) (No. 2010CB933901 and 2011CB933100);National 863 Hi-tech Project of China (No. 2012AA022703), National Natural Scientific Fund (No. 81225010, 81101169 and 31100717);Shanghai Nano project (13NM1401500), Specialized Research Fund for the Doctoral Program of Higher Education (No. 20110073120072)
RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a speci...
关键词：Magnetic impedance Cancer cell Targeted detection Biosensing system Cell cultural chip 
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