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作品数：1594被引量：4548H指数：24
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Glymphatic system:a gateway for neuroinflammation被引量：1
《Neural Regeneration Research》2024年第12期2661-2672,共12页Kailu Zou Qingwei Deng Hong Zhang Changsheng Huang 
supported by the National Natural Science Foundation of China,Nos.82071249 and 81771207 (both to CH)。
The glymphatic system is a relatively recently identified fluid exchange and transpo rt system in the brain.Accumulating evidence indicates thatglymphatic function is impaired not only in central nervous system disord...
关键词：AQUAPORIN-4 central nervous system disease cerebrospinal fluid chronic neuroinflammation glymphatic dysfunction NEURODEGENERATION peripheral nerve injury perivascular space systemic disease vicious cycle 
Regenerative medicine strategies for chronic complete spinal cord injury被引量：2
《Neural Regeneration Research》2024年第4期818-824,共7页Shogo Hashimoto Narihito Nagoshi Masaya Nakamura Hideyuki Okano 
Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases.While rapid progress has been made in regenerative medicine for spinal cord injury that was previou...
关键词：cell transplantation chronic phase complete transection regenerative medicine spinal cord injury 
Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function被引量：4
《Neural Regeneration Research》2023年第11期2449-2458,共10页Jinpiao Zhu Chang Chen Zhen Li Xiaodong Liu Jingang He Ziyue Zhao Mengying He Binbin Nie Zili Liu Yingying Chen Kuanpin Su Xiang Li Juxiang Chen Hongbing Xiang Fuqiang Xu Kangguang Lin Zongze Zhang Jie Wang 
National Natural Science Foundation of China,Nos.81771160 (to ZZ),81671060 (to CC),31970973 (to JW),21921004 (to FX);Translational Medicine and In terdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,No.ZNJC201934 (to ZZ)。
Sleep benefits the restoration of energy metabolism and thereby suppo rts neuronal plasticity and cognitive behaviors.Sirt6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator of...
关键词：chronic sleep deprivation cognitive impairment functional connectivity glutamatergic neurons metabolic kinetics neuronal-astrocytic glucose metabolism prelimbic cortex REM sleep Sirt6 synaptic function 
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury被引量：2
《Neural Regeneration Research》2023年第11期2482-2488,共7页Zhengran Yu Xing Cheng Wenxu Pan Cheng Yu Yang Duan 
Chronic compressive spinal cord injury in compressive cervical myelopathy conditions can lead to rapid neurological deterioration in the early phase,followed by partial self-recovery,and ultimately an equilibrium stat...
关键词：chronic spinal cord compression compressive cervical myelopathy ferroptosis genome-wide transcriptome glutathione peroxidase 4(GPX4) MAF BZIP transcription factor G(MafG) neurological function 
Neuroprotective effect of mesenchymal stem cellderived extracellular vesicles on optic nerve injury in chronic ocular hypertension被引量：7
《Neural Regeneration Research》2023年第10期2301-2306,共6页Fei Yu Yao Wang Chang-Quan Huang Si-Jie Lin Ru-Xin Gao Ren-Yi Wu 
supported by the National Natural Science Foundation of China,No.81570844;the Natural Science Foundation of Fujian Province,No.2011D001;Medical Innovation Program of Fujian Province,No.2011-CXB-47;Huaxia Translational Medicine Youth Foundation,No.2017-A-00301;Xiamen Science and Technology Program Guiding Project,No.3502Z20189033(all to RYW)。
Mesenchymal stem cells have neuroprotective effects that limit damage to the retina and photoreceptors,and which may be mediated by extracellular vesicles(or exosomes)released by mesenchymal stem cells.To investigate ...
关键词：animal model APOPTOSIS chronic glaucoma chronic ocular hypertension extracellular vesicles mesenchymal stem cells NEUROPROTECTION rat retinal ganglion cells umbilical cord 
Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events
《Neural Regeneration Research》2023年第4期790-796,共7页Zhen-Xiao Ren Jing-Hui Xu Xing Cheng Gui-Xing Xu Hou-Qing Long 
supported by the National Natural Science Foundation of China,No.81450020(to HQL)。
Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury,with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis.In the progression of this condition,t...
关键词：ANGIOGENESIS cervical spondylotic myelopathy HYPOXIA inflammation ISCHEMIA spinal cord injury surgical decompression 
The proteome of distal nerves: implication in delayed repair and poor functional recovery
《Neural Regeneration Research》2022年第9期1998-2006,共9页Song Guo Raymond M.Moore M.Cristine Charlesworth Kenneth L.Johnson Robert J.Spinner Anthony J.Windebank Huan Wang 
supported by Helene Houle Career Development Award in Neurologic Surgery Research and Fund for Mayo Clinic Center for Regenerative Medicine Program Director,Neuroregenerative Medicine,Mayo Clinic College of Medicine and Science.SG was supported by the Chinese Scholarship Council.
Chronic denervation is one of the key factors that affect nerve regeneration.Chronic axotomy deteriorates the distal nerve stump,causes protein changes,and renders the microenvironment less permissive for regeneration...
关键词：chronic axotomy chronic denervation delayed repair distal nerve functional recovery nerve regeneration peripheral nerve prolonged denervation PROTEOME sciatic nerve sciatic nerve transection 
Time-to-enrollment in clinical trials investigating neurological recovery in chronic spinal cord injury:observations from a systematic review and Clinical Trials.gov database被引量：1
《Neural Regeneration Research》2022年第5期953-958,共6页F M Moinuddin Yagiz Ugur Yolcu Waseem Wahood Jad Zreik Sandy Goncalves Anthony John Windebank Wenchun Qu Mohamad Bydon 
Currently,large numbers of clinical trials are performed to investigate different forms of experimental therapy for patients suffering from chronic spinal cord injury(SCI).However,for the enrollment process,there are ...
关键词：CHRONIC clinical trial spinal cord injury systematic review time-to-enrollment 
Dendritic spine density changes and homeostatic synaptic scaling:a meta-analysis of animal studies
《Neural Regeneration Research》2022年第1期20-24,共5页Thiago C.Moulin Danielle Rayêe Helgi B.Schiöth 
supported by scholarships from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq);Coordenaao de Aperfeicoamento de Pessoal de Nível Superior(CAPES),Brazil(to TCM and DR);supported by the Kungl Vetenskapssamh Scholarship(Royal Society of Arts and Scientists);provided by Uppsala University,Sweden(to TCM);supported by the Swedish Research Council and the Swedish Brain Research Foundation(to HBS)。
Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity.This type of plasticity is essential for the maintenance of brain circu...
关键词：chronic inhibition chronic stimulation dendritic spines DOWNSCALING EXCITABILITY homeostatic plasticity spine density synaptic scaling upscaling 
Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases被引量：5
《Neural Regeneration Research》2021年第9期1711-1714,共4页Patrick Süβ Addison J.Lana Johannes C.M.Schlachetzki 
The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the...
关键词：aging Alzheimer's disease INFLAMMATION innate immune system MICROGLIA NEURODEGENERATION Parkinson's disease 
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