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DRUG_RESISTANCE: 作品数：794被引量：2506H指数：22; 导出分析报告; 相关作者：许建成张文波吴移谋尹卫国余敏君更多>>; 相关机构：华中科技大学浙江大学吉林大学第一医院南华大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>

Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets: 《Neural Regeneration Research》2026年第1期23-38,共16页Yuncan Chen Jiayi Hu Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang; supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。; Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...; 关键词：ASTROCYTE cellular microenvironment drug resistance EPILEPSY EXCITABILITY homeostasis metabolism neural networks NEUROINFLAMMATION neuron

EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma:A novel gene fusion model report and mechanism research: 《Genes & Diseases》2025年第3期7-10,共4页Qing Pan Wenbo Yang Fuhua Huang Wei Wu Zengwu Shao Zhicai Zhang; supported by the National Natural Science Foundation of China(No.82072979).; Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common ...; 关键词：AUTOPHAGY mesenchymal malignant tumor fusion mode drug resistance ewsr psmc fusion gene gene alterationgene fusion OSTEOSARCOMA genetic changes

Non-coding RNAs as potential mediators of resistance to lung cancer immunotherapy and chemotherapy: 《Oncology Research》2025年第5期1033-1054,共22页JIAHUI WANG HONGCHENG GE ZHENGYUAN YU LINGZHI WU; Lung cancer is a common cause of cancer-related death globally.The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy.However,as the treatment cycle progresses and the disease evolv...; 关键词：Non-coding RNAs(ncRNAs) Lung cancer Drug resistance IMMUNOTHERAPY CHEMOTHERAPY Immune checkpoints Immune escape

The role of glutathione peroxidase 4 in the progression,drug resistance,and targeted therapy of non-small cell lung cancer: 《Oncology Research》2025年第4期863-872,共10页JIAHENG WEI LIANGMING ZHU; Lung cancer is one of the main causes of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)being the most prevalent histological subtype of lung cancer.Glutathione peroxidase 4(GPX4)is a crucial ant...; 关键词：Non-small cell lung cancer(NSCLC) Glutathione peroxidase 4(GPX4) Drug resistance INHIBITOR Biological function

The regulatory role of lncRNA in tumor drug resistance:refracting light through a narrow aperture: 《Oncology Research》2025年第4期837-849,共13页HENG ZHANG XIAO YANG YUJIN GUO HAIBO ZHAO PEI JIANG QING-QING YU; supported by the grant of the Medicine and Health Care Science and Technology Development Plan Projects Foundation of Shandong Province(No.202301060260).; As living conditions improve and diagnostic capabilities advance,the incidence of tumors has increased,with cancer becoming a leading cause of death worldwide.Surgery,chemotherapy,and radiotherapy are the most common ...; 关键词：Long chain non coding RNA(LncRNA) Gene regulatory mechanisms Tumor resistance CHEMOTHERAPY

Progress of research on glucose transporter proteins in hepatocellular carcinoma: 《World Journal of Hepatology》2025年第3期77-89,共13页Zheng Ruan Yan Wang Lei Shi Xiao-Jun Yang; Hepatocellular carcinoma(HCC)is a malignant tumour with high prevalence and mortality rate worldwide.Metabolic reprogramming of cancer cells may be a major factor in the process of this disease.Glucose transporter pro...; 关键词：Hepatocellular carcinoma Glucose transporter protein Metabolic repro-gramming Therapeutic target Drug resistance

ARPC1A Promotes NSCLC Malignancy via Stimulating the Drug Resistance and Cell Migration: 《BIOCELL》2025年第3期483-502,共20页Hongjuan Guo Dan Liu Ruyu Yan Tianjing Zhang Kecheng Zhou Minxia Liu; supported by the Natural Science Foundation of Anhui Province(ML 2308085MC80);the Anhui Medical University Research and Innovation Talent Team(KZ).; Objectives:Non-small cell lung cancer(NSCLC)represents a formidable malignancy characterized by its marked metastatic potential and intrinsic resistance to therapeutic interventions.The identification of potential bio...; 关键词：NSCLC ARPC1A drug resistance EMT immune infiltration dynamics

Carbapenem-resistant Klebsiella pneumoniae infections after liver transplantation:Drug resistance,risk factors and impact on prognosis: 《World Journal of Gastroenterology》2025年第8期38-48,共11页Tao-Hua Liu Li-Hua Chen Qi-Quan Wan; BACKGROUND Liver transplant(LT)recipients are susceptible to carbapenem-resistant Klebsiella pneumoniae(CRKP)infections.Comprehensive research addressing the incidence,timing,infection sites,resistance patterns,treatm...; 关键词：Liver transplantation Carbapenem-resistant Klebsiella pneumonia Antibiotic resistance Infection IMMUNOSUPPRESSION Risk factors

Salidroside Enhances the Sensitivity of Lung Cancer Cells to Paclitaxel by Regulating the Wnt/β-catenin Signaling Pathway: 《Current Medical Science》2025年第1期104-113,共10页Guo-liang Pi Liang-hao Cheng Bin-feng Li Fei Ming; supported by the Scientific Research Project of Hubei Cancer Hospital(No.2024HBCHYN08);the Natural Science Foundation of Hubei Province(No.2023AFB988);the Scientific Research Project in the Field of Oncology(No.FB2024025225);the Talent Project of Hubei Cancer Hospital(No.2025HBCHHHRC007).; Objective Chemoresistance,such as paclitaxel(PTX)resistance,has become a great obstacle in non-small cell lung cancer(NSCLC)treatment.The natural agent salidroside(SAL)has been shown to exert an antitumor effect on NS...; 关键词：Lung cancer SALIDROSIDE Drug resistance PACLITAXEL WNT/Β-CATENIN

Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARαin acute promyelocytic leukemia: 《Acta Pharmacologica Sinica》2025年第2期462-473,共12页Xue-jing Shao Wei Wang Ai-xiao Xu Xiao-tian Qi Min-yi Cai Wen-xin Du Ji Cao Qiao-jun He Mei-dan Ying Bo Yang; supported by grants from the National Key R&D Program of China(2021YFA1300604);the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province(LR24H310001);the Fundamental Research Funds for the Central Universities.; The oncogenic fusion protein promyelocytic leukemia/retinoic acid receptor alpha(PML/RARα)is critical for acute promyelocytic leukemia(APL).PML/RARαinitiates APL by blocking the differentiation and increasing the se...; 关键词：acute promyelocytic leukemia PML/RARa drug resistance PALMITOYLATION ZDHHC3

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