ENDOTHELIAL_CELLS

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Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease
《Neural Regeneration Research》2026年第2期569-576,共8页Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi 
supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ);the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ;the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH);the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ);the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).
Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...
关键词：Alzheimer’s disease brain microvessel endothelial cells transcriptomic heterogeneity endothelial activation blood-brain barrier impairment neurovascular cell-cell communication 
Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer's disease:transcriptomics combined with machine learning analysis
《Neural Regeneration Research》2025年第12期3620-3634,共15页Meiling Wang Aojie He Yubing Kang Zhaojun Wang Yahui He Kahleong Lim Chengwu Zhang Li Lu 
supported by the Natural Science Foundation of Shanxi Province,No.20210302123299;The Belt and Road Program of Shanxi Province,No.110000261420228002(both to CZ)。
Studies have shown that vascular dysfunction is closely related to the pathogenesis of Alzheimer's disease.The middle temporal gyrus region of the brain is susceptible to pronounced impairment in Alzheimer's disease.I...
关键词：Alzheimer’s disease bioinformatics CellChat cerebrovascular disorders endothelial cells intercellular communication machine learning middle temporal gyrus PERICYTES vascular endothelial growth factor pathway 
Revisiting cerebral endothelial cells in Alzheimer’s disease
《Neural Regeneration Research》2025年第10期2911-2912,共2页Amira S.Hanafy 
funded by the Deutsche Forschungsgemeinschaft(DFG),the BONFOR program of the Medical Faculty of the University of Bonn,and the Alexander-von-Humboldt Foundation.
Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory functions.In only approximately 5%of the cases,AD is familial,as often predis...
关键词：ALZHEIMER AΒ CEREBRAL 
Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system
《Neural Regeneration Research》2025年第6期1715-1716,共2页Dan Ma Nona Pop 
supported by a grant from Aston University,Birmingham,UK (to DM)。
Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseas...
关键词：MYELIN protective DISEASES 
EGFR-mediated crosstalk between vascularendothelial cells and hepatocytes promotesPiezo1-dependent liver regeneration
《Genes & Diseases》2025年第3期411-427,共17页Yuelei Hu Guifang Du Chao Li Rui Wang Juan Liu Yunfang Wang Jiahong Dong 
supported by the National Key Research and Development Program of China(No.2022YFA1103400);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5e056);the National Natural Science Foundation of China(No.81930119,92168207,32371477,82090051);the Precision Medicine Research Program of Tsinghua University(No.10001020612);the National High Level Hospital Clinical Research Funding(China)(No.2022-NHLHCRF-LX-03-0102).
Hepatocyte proliferation is essential for recovering liver function after injury. Inliver surgery, the mechanical stimulation induced by hemodynamic changes triggers vascularendothelial cells (VECs) to secrete large a...
关键词：EGFR Hemodynamic changes Liver regeneration Piezo1 Vascular endothelial cells 
Retinal Focus on Relationships between Diet-Induced, Advanced Glycation End Products and Supplemental Estradiol
《BIOCELL》2025年第3期349-354,共6页Nicholas T.Bello Bonnie L.Firestein Maribel Vazquez 
funded by a Life Sciences Alliance Pilot Seed Grant from the Rutgers-New Brunswick Office of the Vice Provost for Research,Grant Number OVPR-100(MV)。
Neurodegeneration of retinal tissue leads to progressive vision loss in millions of working-age adults each year.Metabolic alterations caused by modern diets that are high in fats and sugars contribute to the developm...
关键词：Muller glia endothelial cells HYPERGLYCEMIA diabetes 
Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery
《Neural Regeneration Research》2025年第1期224-233,共10页Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang 
supported by the NIH grants,R01 NS111801(to ZGZ);American Heart Association 16SDG29860003(to YZ)。
Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional recovery.Our previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)iso...
关键词：axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke 
ELK1-CDKL5-Rac1 signaling pathway regulates the migration of endothelial cells to promote angiogenesis induced by nanoniobium particles
《Rare Metals》2025年第1期444-460,共17页Xiao-He Zhou Min-Hua Mo Zi-Wei Chen Wen-Jing Liu Yan-Li Zhang Janak LPathak Li-Jing Wang Chang Liu Long-Quan Shao Liang-Jiao Chen 
supported by Guangzhou Science and Technology Plan Project(No.2023A03J0328);the National Natural Science Foundation of China(No.81600904)。
Promotion of angiogenesis is crucial for bone tissue repair,and the poor activity of angiogenic cells and growth factors is the main problem in angiogenesis.New proangiogenic nanomaterials are urgently needed to be a ...
关键词：Nanoniobium particles ANGIOGENESIS Endothelial cells MIGRATION ELK1-CDKL5-Rac1 signaling pathway 
Vascular wall microenvironment:Endothelial cells original exosomes mediated melatonin-suppressed vascular calcification and vascular ageing in a m6A methylation dependent manner
《Bioactive Materials》2024年第12期52-67,共16页Su-Kang Shan Xiao Lin Feng Wu Chang-Chun Li Bei Guo Fu-Xing-Zi Li Ming-Hui Zheng Yi Wang Qiu-Shuang Xu Li-Min Lei Ke-Xin Tang Yun-Yun Wu Jia-Yue Duan Ye-Chi Cao Yan-Lin Wu Chang-Ming Tan Zi-Han Liu Zhi-Ang Zhou Xiao-Bo Liao Feng Xu Ling-Qing Yuan 
supported by National Key Research&Development Program(No.2021YFC2501701 to LQY and FX);the National Natural Science Foundation of China(No.82370892 and 82070910 to LQY,No.82100494 to FX,No.82100944 and No.82470927 to XL,No.82200869 to FW);National Clinical Key Specialties Main Research Projects(2023026 to LQY);the Natural Science Foundation of Hunan Province(No.2022JJ40721 to FX);the Health Research Project in Hunan Province(No.20231696 to XL);the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University(No.7673 to FX).
Vascular calcification and vascular ageing are“silent”diseases but are highly prevalent in patients with end stage renal failure and type 2 diabetes,as well as in the ageing population.Melatonin(MT)has been shown to...
关键词：MELATONIN Vascular calcification Vascular ageing EXOSOMES N6-methyladenosine 
Histone deacetylases:Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis
《Genes & Diseases》2024年第6期351-366,共16页Hanyi Yang Kai Guo Peng Ding Jiayi Ning Yimeng Zhang Yuanyong Wang Zhaoyang Wang Guanglin Liu Changjian Shao Minghong Pan Zhiqiang Ma Xiaolong Yan Jing Han 
supported by the National Natural Science Foundation of China (No.82103508,82203758);Natural Science Foundation of Shaanxi Province (China) (No.SZYKJCYC-2023-028);the Science and Technology Development Incubation Fund of Shaanxi Provincial People's Hospital,Shaanxi,China (No.2021YJY-21);the Project of Tangdu Hospital,the Air Force Medical University,Shaanxi,China (No.XJSXYW202130,XJSXYW-2023015,2021LCYJ019);the Project of Air Foce Medical University,Shaanxi,China (No.2022LC2227);the Talent Support Program of Shaanxi Provincial People's Hospital,Shaanxi,China (No.2022JY-38).
tHistone deacetylases(HDACs)are proteases that play a key role in chromosome structural modification and gene expression regulation,and the involvement of HDACs in can-cer,the nervous system,and the metabolic and immu...
关键词：DEACETYLATION Endothelial cells Histone deacetylase Vascular disease Vascular smooth muscle cells 
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